SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan

The extension in human lifespan in the last century results in a significant increase in incidence of age related diseases. It is therefore crucial to identify key factors that control elderly healthspan. Similar to dietary restriction, mice overexpressing the NAD+ dependent protein deacylase SIRT6...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2017-05, Vol.72 (5), p.603-615
Hauptverfasser:	Roichman, Asael, Kanfi, Yariv, Glazz, Renana, Naiman, Shoshana, Amit, Uri, Landa, Natalie, Tinman, Simon, Stein, Ilan, Pikarsky, Eli, Leor, Jonathan, Cohen, Haim Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism AMP AMP-activated protein kinase Animals Blood Chemical Analysis Body Composition Calorimetry, Indirect Dietary restrictions DNA - analysis Exercise Gene Expression Geriatrics Glucose Glucose tolerance Glucose Tolerance Test Hair - growth & development Immunoblotting Immunohistochemistry Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Life span Longevity Mice Mice, Inbred BALB C Mice, Inbred C57BL Microarray Analysis NAD Phenotype Physical activity Proteins Real-Time Polymerase Chain Reaction RNA - analysis Rodents Sirtuins - metabolism Up-Regulation Wound Healing - physiology
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