Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease

Traumatic brain injury (TBI) has been suggested to increase the risk of amyotrophic lateral sclerosis (ALS). However, this link remains controversial and as such, here we performed experimental moderate TBI in rats and assessed for the presence of ALS-like pathological and functional abnormalities a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2017-09, Vol.27 (9), p.4503-4515
Hauptverfasser: Wright, David K, Liu, Shijie, van der Poel, Chris, McDonald, Stuart J, Brady, Rhys D, Taylor, Lily, Yang, Li, Gardner, Andrew J, Ordidge, Roger, O'Brien, Terence J, Johnston, Leigh A, Shultz, Sandy R
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 4515
container_issue 9
container_start_page 4503
container_title Cerebral cortex (New York, N.Y. 1991)
container_volume 27
creator Wright, David K
Liu, Shijie
van der Poel, Chris
McDonald, Stuart J
Brady, Rhys D
Taylor, Lily
Yang, Li
Gardner, Andrew J
Ordidge, Roger
O'Brien, Terence J
Johnston, Leigh A
Shultz, Sandy R
description Traumatic brain injury (TBI) has been suggested to increase the risk of amyotrophic lateral sclerosis (ALS). However, this link remains controversial and as such, here we performed experimental moderate TBI in rats and assessed for the presence of ALS-like pathological and functional abnormalities at both 1 and 12 weeks post-injury. Serial in-vivo magnetic resonance imaging (MRI) demonstrated that rats given a TBI had progressive atrophy of the motor cortices and degeneration of the corticospinal tracts compared with sham-injured rats. Immunofluorescence analyses revealed a progressive reduction in neurons, as well as increased phosphorylated transactive response DNA-binding protein 43 (TDP-43) and cytoplasmic TDP-43, in the motor cortex of rats given a TBI. Rats given a TBI also had fewer spinal cord motor neurons, increased expression of muscle atrophy markers, and altered muscle fiber contractile properties compared with sham-injured rats at 12 weeks, but not 1 week, post-injury. All of these changes occurred in the presence of persisting motor deficits. These findings resemble some of the pathological and functional abnormalities common in ALS and support the notion that TBI can result in a progressive neurodegenerative disease process pathologically bearing similarities to a motor neuron disease.
doi_str_mv 10.1093/cercor/bhw254
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859719275</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859719275</sourcerecordid><originalsourceid>FETCH-LOGICAL-c332t-eace1d2c1ecff0cd390cecf66d135c92b95e7d74b754b674353f3c3afede81653</originalsourceid><addsrcrecordid>eNo9kE1PwzAMhiMEYjA4ckU5cqAsH02zHKEwmDRAgnGu0tTdOrXpSBqh_Xs6dXDya-uxJT8IXVFyR4niEwPOtG6Sr3-YiI_QGY0TEjGq1HGfSSwjzigdoXPvN4RQyQQ7RSMmRZIoKc9Qs3Q6NLqrDH5wurJ4bjfB7fAH-FB3HveTFOo61Nrd4s_OBdMFp2usbYFnwZquam3fpmttV-D3a9DkdWVX-LXtWoffILjW4sfKg_ZwgU5KXXu4PNQx-po9LdOXaPH-PE_vF5HhnHURaAO0YIaCKUtiCq6I6WOSFJQLo1iuBMhCxrkUcZ7ImAtecsN1CQVMaSL4GN0Md7eu_Q7gu6ypvOn_0Bba4DM6FUpS1Wvo0WhAjWu9d1BmW1c12u0ySrK94WwwnA2Ge_76cDrkDRT_9J9S_gvpOHt7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859719275</pqid></control><display><type>article</type><title>Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Wright, David K ; Liu, Shijie ; van der Poel, Chris ; McDonald, Stuart J ; Brady, Rhys D ; Taylor, Lily ; Yang, Li ; Gardner, Andrew J ; Ordidge, Roger ; O'Brien, Terence J ; Johnston, Leigh A ; Shultz, Sandy R</creator><creatorcontrib>Wright, David K ; Liu, Shijie ; van der Poel, Chris ; McDonald, Stuart J ; Brady, Rhys D ; Taylor, Lily ; Yang, Li ; Gardner, Andrew J ; Ordidge, Roger ; O'Brien, Terence J ; Johnston, Leigh A ; Shultz, Sandy R</creatorcontrib><description>Traumatic brain injury (TBI) has been suggested to increase the risk of amyotrophic lateral sclerosis (ALS). However, this link remains controversial and as such, here we performed experimental moderate TBI in rats and assessed for the presence of ALS-like pathological and functional abnormalities at both 1 and 12 weeks post-injury. Serial in-vivo magnetic resonance imaging (MRI) demonstrated that rats given a TBI had progressive atrophy of the motor cortices and degeneration of the corticospinal tracts compared with sham-injured rats. Immunofluorescence analyses revealed a progressive reduction in neurons, as well as increased phosphorylated transactive response DNA-binding protein 43 (TDP-43) and cytoplasmic TDP-43, in the motor cortex of rats given a TBI. Rats given a TBI also had fewer spinal cord motor neurons, increased expression of muscle atrophy markers, and altered muscle fiber contractile properties compared with sham-injured rats at 12 weeks, but not 1 week, post-injury. All of these changes occurred in the presence of persisting motor deficits. These findings resemble some of the pathological and functional abnormalities common in ALS and support the notion that TBI can result in a progressive neurodegenerative disease process pathologically bearing similarities to a motor neuron disease.</description><identifier>ISSN: 1047-3211</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhw254</identifier><identifier>PMID: 27566977</identifier><language>eng</language><publisher>United States</publisher><subject>Amyotrophic Lateral Sclerosis - physiopathology ; Animals ; Brain Injuries, Traumatic - complications ; Cytoplasm - metabolism ; Disease Models, Animal ; DNA-Binding Proteins - metabolism ; Male ; Motor Cortex - physiopathology ; Motor Neuron Disease - etiology ; Motor Neuron Disease - physiopathology ; Rats, Long-Evans ; Spinal Cord - physiopathology</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2017-09, Vol.27 (9), p.4503-4515</ispartof><rights>The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-eace1d2c1ecff0cd390cecf66d135c92b95e7d74b754b674353f3c3afede81653</citedby><cites>FETCH-LOGICAL-c332t-eace1d2c1ecff0cd390cecf66d135c92b95e7d74b754b674353f3c3afede81653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27566977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wright, David K</creatorcontrib><creatorcontrib>Liu, Shijie</creatorcontrib><creatorcontrib>van der Poel, Chris</creatorcontrib><creatorcontrib>McDonald, Stuart J</creatorcontrib><creatorcontrib>Brady, Rhys D</creatorcontrib><creatorcontrib>Taylor, Lily</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>Gardner, Andrew J</creatorcontrib><creatorcontrib>Ordidge, Roger</creatorcontrib><creatorcontrib>O'Brien, Terence J</creatorcontrib><creatorcontrib>Johnston, Leigh A</creatorcontrib><creatorcontrib>Shultz, Sandy R</creatorcontrib><title>Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Traumatic brain injury (TBI) has been suggested to increase the risk of amyotrophic lateral sclerosis (ALS). However, this link remains controversial and as such, here we performed experimental moderate TBI in rats and assessed for the presence of ALS-like pathological and functional abnormalities at both 1 and 12 weeks post-injury. Serial in-vivo magnetic resonance imaging (MRI) demonstrated that rats given a TBI had progressive atrophy of the motor cortices and degeneration of the corticospinal tracts compared with sham-injured rats. Immunofluorescence analyses revealed a progressive reduction in neurons, as well as increased phosphorylated transactive response DNA-binding protein 43 (TDP-43) and cytoplasmic TDP-43, in the motor cortex of rats given a TBI. Rats given a TBI also had fewer spinal cord motor neurons, increased expression of muscle atrophy markers, and altered muscle fiber contractile properties compared with sham-injured rats at 12 weeks, but not 1 week, post-injury. All of these changes occurred in the presence of persisting motor deficits. These findings resemble some of the pathological and functional abnormalities common in ALS and support the notion that TBI can result in a progressive neurodegenerative disease process pathologically bearing similarities to a motor neuron disease.</description><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Animals</subject><subject>Brain Injuries, Traumatic - complications</subject><subject>Cytoplasm - metabolism</subject><subject>Disease Models, Animal</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Male</subject><subject>Motor Cortex - physiopathology</subject><subject>Motor Neuron Disease - etiology</subject><subject>Motor Neuron Disease - physiopathology</subject><subject>Rats, Long-Evans</subject><subject>Spinal Cord - physiopathology</subject><issn>1047-3211</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhiMEYjA4ckU5cqAsH02zHKEwmDRAgnGu0tTdOrXpSBqh_Xs6dXDya-uxJT8IXVFyR4niEwPOtG6Sr3-YiI_QGY0TEjGq1HGfSSwjzigdoXPvN4RQyQQ7RSMmRZIoKc9Qs3Q6NLqrDH5wurJ4bjfB7fAH-FB3HveTFOo61Nrd4s_OBdMFp2usbYFnwZquam3fpmttV-D3a9DkdWVX-LXtWoffILjW4sfKg_ZwgU5KXXu4PNQx-po9LdOXaPH-PE_vF5HhnHURaAO0YIaCKUtiCq6I6WOSFJQLo1iuBMhCxrkUcZ7ImAtecsN1CQVMaSL4GN0Md7eu_Q7gu6ypvOn_0Bba4DM6FUpS1Wvo0WhAjWu9d1BmW1c12u0ySrK94WwwnA2Ge_76cDrkDRT_9J9S_gvpOHt7</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Wright, David K</creator><creator>Liu, Shijie</creator><creator>van der Poel, Chris</creator><creator>McDonald, Stuart J</creator><creator>Brady, Rhys D</creator><creator>Taylor, Lily</creator><creator>Yang, Li</creator><creator>Gardner, Andrew J</creator><creator>Ordidge, Roger</creator><creator>O'Brien, Terence J</creator><creator>Johnston, Leigh A</creator><creator>Shultz, Sandy R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease</title><author>Wright, David K ; Liu, Shijie ; van der Poel, Chris ; McDonald, Stuart J ; Brady, Rhys D ; Taylor, Lily ; Yang, Li ; Gardner, Andrew J ; Ordidge, Roger ; O'Brien, Terence J ; Johnston, Leigh A ; Shultz, Sandy R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-eace1d2c1ecff0cd390cecf66d135c92b95e7d74b754b674353f3c3afede81653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amyotrophic Lateral Sclerosis - physiopathology</topic><topic>Animals</topic><topic>Brain Injuries, Traumatic - complications</topic><topic>Cytoplasm - metabolism</topic><topic>Disease Models, Animal</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Male</topic><topic>Motor Cortex - physiopathology</topic><topic>Motor Neuron Disease - etiology</topic><topic>Motor Neuron Disease - physiopathology</topic><topic>Rats, Long-Evans</topic><topic>Spinal Cord - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wright, David K</creatorcontrib><creatorcontrib>Liu, Shijie</creatorcontrib><creatorcontrib>van der Poel, Chris</creatorcontrib><creatorcontrib>McDonald, Stuart J</creatorcontrib><creatorcontrib>Brady, Rhys D</creatorcontrib><creatorcontrib>Taylor, Lily</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>Gardner, Andrew J</creatorcontrib><creatorcontrib>Ordidge, Roger</creatorcontrib><creatorcontrib>O'Brien, Terence J</creatorcontrib><creatorcontrib>Johnston, Leigh A</creatorcontrib><creatorcontrib>Shultz, Sandy R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wright, David K</au><au>Liu, Shijie</au><au>van der Poel, Chris</au><au>McDonald, Stuart J</au><au>Brady, Rhys D</au><au>Taylor, Lily</au><au>Yang, Li</au><au>Gardner, Andrew J</au><au>Ordidge, Roger</au><au>O'Brien, Terence J</au><au>Johnston, Leigh A</au><au>Shultz, Sandy R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease</atitle><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle><addtitle>Cereb Cortex</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>27</volume><issue>9</issue><spage>4503</spage><epage>4515</epage><pages>4503-4515</pages><issn>1047-3211</issn><eissn>1460-2199</eissn><abstract>Traumatic brain injury (TBI) has been suggested to increase the risk of amyotrophic lateral sclerosis (ALS). However, this link remains controversial and as such, here we performed experimental moderate TBI in rats and assessed for the presence of ALS-like pathological and functional abnormalities at both 1 and 12 weeks post-injury. Serial in-vivo magnetic resonance imaging (MRI) demonstrated that rats given a TBI had progressive atrophy of the motor cortices and degeneration of the corticospinal tracts compared with sham-injured rats. Immunofluorescence analyses revealed a progressive reduction in neurons, as well as increased phosphorylated transactive response DNA-binding protein 43 (TDP-43) and cytoplasmic TDP-43, in the motor cortex of rats given a TBI. Rats given a TBI also had fewer spinal cord motor neurons, increased expression of muscle atrophy markers, and altered muscle fiber contractile properties compared with sham-injured rats at 12 weeks, but not 1 week, post-injury. All of these changes occurred in the presence of persisting motor deficits. These findings resemble some of the pathological and functional abnormalities common in ALS and support the notion that TBI can result in a progressive neurodegenerative disease process pathologically bearing similarities to a motor neuron disease.</abstract><cop>United States</cop><pmid>27566977</pmid><doi>10.1093/cercor/bhw254</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1047-3211
ispartof Cerebral cortex (New York, N.Y. 1991), 2017-09, Vol.27 (9), p.4503-4515
issn 1047-3211
1460-2199
language eng
recordid cdi_proquest_miscellaneous_1859719275
source Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Amyotrophic Lateral Sclerosis - physiopathology
Animals
Brain Injuries, Traumatic - complications
Cytoplasm - metabolism
Disease Models, Animal
DNA-Binding Proteins - metabolism
Male
Motor Cortex - physiopathology
Motor Neuron Disease - etiology
Motor Neuron Disease - physiopathology
Rats, Long-Evans
Spinal Cord - physiopathology
title Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T20%3A47%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Traumatic%20Brain%20Injury%20Results%20in%20Cellular,%20Structural%20and%20Functional%20Changes%20Resembling%20Motor%20Neuron%20Disease&rft.jtitle=Cerebral%20cortex%20(New%20York,%20N.Y.%201991)&rft.au=Wright,%20David%20K&rft.date=2017-09-01&rft.volume=27&rft.issue=9&rft.spage=4503&rft.epage=4515&rft.pages=4503-4515&rft.issn=1047-3211&rft.eissn=1460-2199&rft_id=info:doi/10.1093/cercor/bhw254&rft_dat=%3Cproquest_cross%3E1859719275%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1859719275&rft_id=info:pmid/27566977&rfr_iscdi=true