Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease
Traumatic brain injury (TBI) has been suggested to increase the risk of amyotrophic lateral sclerosis (ALS). However, this link remains controversial and as such, here we performed experimental moderate TBI in rats and assessed for the presence of ALS-like pathological and functional abnormalities a...
Gespeichert in:
Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2017-09, Vol.27 (9), p.4503-4515 |
---|---|
Hauptverfasser: | , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 4515 |
---|---|
container_issue | 9 |
container_start_page | 4503 |
container_title | Cerebral cortex (New York, N.Y. 1991) |
container_volume | 27 |
creator | Wright, David K Liu, Shijie van der Poel, Chris McDonald, Stuart J Brady, Rhys D Taylor, Lily Yang, Li Gardner, Andrew J Ordidge, Roger O'Brien, Terence J Johnston, Leigh A Shultz, Sandy R |
description | Traumatic brain injury (TBI) has been suggested to increase the risk of amyotrophic lateral sclerosis (ALS). However, this link remains controversial and as such, here we performed experimental moderate TBI in rats and assessed for the presence of ALS-like pathological and functional abnormalities at both 1 and 12 weeks post-injury. Serial in-vivo magnetic resonance imaging (MRI) demonstrated that rats given a TBI had progressive atrophy of the motor cortices and degeneration of the corticospinal tracts compared with sham-injured rats. Immunofluorescence analyses revealed a progressive reduction in neurons, as well as increased phosphorylated transactive response DNA-binding protein 43 (TDP-43) and cytoplasmic TDP-43, in the motor cortex of rats given a TBI. Rats given a TBI also had fewer spinal cord motor neurons, increased expression of muscle atrophy markers, and altered muscle fiber contractile properties compared with sham-injured rats at 12 weeks, but not 1 week, post-injury. All of these changes occurred in the presence of persisting motor deficits. These findings resemble some of the pathological and functional abnormalities common in ALS and support the notion that TBI can result in a progressive neurodegenerative disease process pathologically bearing similarities to a motor neuron disease. |
doi_str_mv | 10.1093/cercor/bhw254 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859719275</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859719275</sourcerecordid><originalsourceid>FETCH-LOGICAL-c332t-eace1d2c1ecff0cd390cecf66d135c92b95e7d74b754b674353f3c3afede81653</originalsourceid><addsrcrecordid>eNo9kE1PwzAMhiMEYjA4ckU5cqAsH02zHKEwmDRAgnGu0tTdOrXpSBqh_Xs6dXDya-uxJT8IXVFyR4niEwPOtG6Sr3-YiI_QGY0TEjGq1HGfSSwjzigdoXPvN4RQyQQ7RSMmRZIoKc9Qs3Q6NLqrDH5wurJ4bjfB7fAH-FB3HveTFOo61Nrd4s_OBdMFp2usbYFnwZquam3fpmttV-D3a9DkdWVX-LXtWoffILjW4sfKg_ZwgU5KXXu4PNQx-po9LdOXaPH-PE_vF5HhnHURaAO0YIaCKUtiCq6I6WOSFJQLo1iuBMhCxrkUcZ7ImAtecsN1CQVMaSL4GN0Md7eu_Q7gu6ypvOn_0Bba4DM6FUpS1Wvo0WhAjWu9d1BmW1c12u0ySrK94WwwnA2Ge_76cDrkDRT_9J9S_gvpOHt7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859719275</pqid></control><display><type>article</type><title>Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Wright, David K ; Liu, Shijie ; van der Poel, Chris ; McDonald, Stuart J ; Brady, Rhys D ; Taylor, Lily ; Yang, Li ; Gardner, Andrew J ; Ordidge, Roger ; O'Brien, Terence J ; Johnston, Leigh A ; Shultz, Sandy R</creator><creatorcontrib>Wright, David K ; Liu, Shijie ; van der Poel, Chris ; McDonald, Stuart J ; Brady, Rhys D ; Taylor, Lily ; Yang, Li ; Gardner, Andrew J ; Ordidge, Roger ; O'Brien, Terence J ; Johnston, Leigh A ; Shultz, Sandy R</creatorcontrib><description>Traumatic brain injury (TBI) has been suggested to increase the risk of amyotrophic lateral sclerosis (ALS). However, this link remains controversial and as such, here we performed experimental moderate TBI in rats and assessed for the presence of ALS-like pathological and functional abnormalities at both 1 and 12 weeks post-injury. Serial in-vivo magnetic resonance imaging (MRI) demonstrated that rats given a TBI had progressive atrophy of the motor cortices and degeneration of the corticospinal tracts compared with sham-injured rats. Immunofluorescence analyses revealed a progressive reduction in neurons, as well as increased phosphorylated transactive response DNA-binding protein 43 (TDP-43) and cytoplasmic TDP-43, in the motor cortex of rats given a TBI. Rats given a TBI also had fewer spinal cord motor neurons, increased expression of muscle atrophy markers, and altered muscle fiber contractile properties compared with sham-injured rats at 12 weeks, but not 1 week, post-injury. All of these changes occurred in the presence of persisting motor deficits. These findings resemble some of the pathological and functional abnormalities common in ALS and support the notion that TBI can result in a progressive neurodegenerative disease process pathologically bearing similarities to a motor neuron disease.</description><identifier>ISSN: 1047-3211</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhw254</identifier><identifier>PMID: 27566977</identifier><language>eng</language><publisher>United States</publisher><subject>Amyotrophic Lateral Sclerosis - physiopathology ; Animals ; Brain Injuries, Traumatic - complications ; Cytoplasm - metabolism ; Disease Models, Animal ; DNA-Binding Proteins - metabolism ; Male ; Motor Cortex - physiopathology ; Motor Neuron Disease - etiology ; Motor Neuron Disease - physiopathology ; Rats, Long-Evans ; Spinal Cord - physiopathology</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2017-09, Vol.27 (9), p.4503-4515</ispartof><rights>The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-eace1d2c1ecff0cd390cecf66d135c92b95e7d74b754b674353f3c3afede81653</citedby><cites>FETCH-LOGICAL-c332t-eace1d2c1ecff0cd390cecf66d135c92b95e7d74b754b674353f3c3afede81653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27566977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wright, David K</creatorcontrib><creatorcontrib>Liu, Shijie</creatorcontrib><creatorcontrib>van der Poel, Chris</creatorcontrib><creatorcontrib>McDonald, Stuart J</creatorcontrib><creatorcontrib>Brady, Rhys D</creatorcontrib><creatorcontrib>Taylor, Lily</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>Gardner, Andrew J</creatorcontrib><creatorcontrib>Ordidge, Roger</creatorcontrib><creatorcontrib>O'Brien, Terence J</creatorcontrib><creatorcontrib>Johnston, Leigh A</creatorcontrib><creatorcontrib>Shultz, Sandy R</creatorcontrib><title>Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Traumatic brain injury (TBI) has been suggested to increase the risk of amyotrophic lateral sclerosis (ALS). However, this link remains controversial and as such, here we performed experimental moderate TBI in rats and assessed for the presence of ALS-like pathological and functional abnormalities at both 1 and 12 weeks post-injury. Serial in-vivo magnetic resonance imaging (MRI) demonstrated that rats given a TBI had progressive atrophy of the motor cortices and degeneration of the corticospinal tracts compared with sham-injured rats. Immunofluorescence analyses revealed a progressive reduction in neurons, as well as increased phosphorylated transactive response DNA-binding protein 43 (TDP-43) and cytoplasmic TDP-43, in the motor cortex of rats given a TBI. Rats given a TBI also had fewer spinal cord motor neurons, increased expression of muscle atrophy markers, and altered muscle fiber contractile properties compared with sham-injured rats at 12 weeks, but not 1 week, post-injury. All of these changes occurred in the presence of persisting motor deficits. These findings resemble some of the pathological and functional abnormalities common in ALS and support the notion that TBI can result in a progressive neurodegenerative disease process pathologically bearing similarities to a motor neuron disease.</description><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Animals</subject><subject>Brain Injuries, Traumatic - complications</subject><subject>Cytoplasm - metabolism</subject><subject>Disease Models, Animal</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Male</subject><subject>Motor Cortex - physiopathology</subject><subject>Motor Neuron Disease - etiology</subject><subject>Motor Neuron Disease - physiopathology</subject><subject>Rats, Long-Evans</subject><subject>Spinal Cord - physiopathology</subject><issn>1047-3211</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhiMEYjA4ckU5cqAsH02zHKEwmDRAgnGu0tTdOrXpSBqh_Xs6dXDya-uxJT8IXVFyR4niEwPOtG6Sr3-YiI_QGY0TEjGq1HGfSSwjzigdoXPvN4RQyQQ7RSMmRZIoKc9Qs3Q6NLqrDH5wurJ4bjfB7fAH-FB3HveTFOo61Nrd4s_OBdMFp2usbYFnwZquam3fpmttV-D3a9DkdWVX-LXtWoffILjW4sfKg_ZwgU5KXXu4PNQx-po9LdOXaPH-PE_vF5HhnHURaAO0YIaCKUtiCq6I6WOSFJQLo1iuBMhCxrkUcZ7ImAtecsN1CQVMaSL4GN0Md7eu_Q7gu6ypvOn_0Bba4DM6FUpS1Wvo0WhAjWu9d1BmW1c12u0ySrK94WwwnA2Ge_76cDrkDRT_9J9S_gvpOHt7</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Wright, David K</creator><creator>Liu, Shijie</creator><creator>van der Poel, Chris</creator><creator>McDonald, Stuart J</creator><creator>Brady, Rhys D</creator><creator>Taylor, Lily</creator><creator>Yang, Li</creator><creator>Gardner, Andrew J</creator><creator>Ordidge, Roger</creator><creator>O'Brien, Terence J</creator><creator>Johnston, Leigh A</creator><creator>Shultz, Sandy R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease</title><author>Wright, David K ; Liu, Shijie ; van der Poel, Chris ; McDonald, Stuart J ; Brady, Rhys D ; Taylor, Lily ; Yang, Li ; Gardner, Andrew J ; Ordidge, Roger ; O'Brien, Terence J ; Johnston, Leigh A ; Shultz, Sandy R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-eace1d2c1ecff0cd390cecf66d135c92b95e7d74b754b674353f3c3afede81653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amyotrophic Lateral Sclerosis - physiopathology</topic><topic>Animals</topic><topic>Brain Injuries, Traumatic - complications</topic><topic>Cytoplasm - metabolism</topic><topic>Disease Models, Animal</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Male</topic><topic>Motor Cortex - physiopathology</topic><topic>Motor Neuron Disease - etiology</topic><topic>Motor Neuron Disease - physiopathology</topic><topic>Rats, Long-Evans</topic><topic>Spinal Cord - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wright, David K</creatorcontrib><creatorcontrib>Liu, Shijie</creatorcontrib><creatorcontrib>van der Poel, Chris</creatorcontrib><creatorcontrib>McDonald, Stuart J</creatorcontrib><creatorcontrib>Brady, Rhys D</creatorcontrib><creatorcontrib>Taylor, Lily</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>Gardner, Andrew J</creatorcontrib><creatorcontrib>Ordidge, Roger</creatorcontrib><creatorcontrib>O'Brien, Terence J</creatorcontrib><creatorcontrib>Johnston, Leigh A</creatorcontrib><creatorcontrib>Shultz, Sandy R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wright, David K</au><au>Liu, Shijie</au><au>van der Poel, Chris</au><au>McDonald, Stuart J</au><au>Brady, Rhys D</au><au>Taylor, Lily</au><au>Yang, Li</au><au>Gardner, Andrew J</au><au>Ordidge, Roger</au><au>O'Brien, Terence J</au><au>Johnston, Leigh A</au><au>Shultz, Sandy R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease</atitle><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle><addtitle>Cereb Cortex</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>27</volume><issue>9</issue><spage>4503</spage><epage>4515</epage><pages>4503-4515</pages><issn>1047-3211</issn><eissn>1460-2199</eissn><abstract>Traumatic brain injury (TBI) has been suggested to increase the risk of amyotrophic lateral sclerosis (ALS). However, this link remains controversial and as such, here we performed experimental moderate TBI in rats and assessed for the presence of ALS-like pathological and functional abnormalities at both 1 and 12 weeks post-injury. Serial in-vivo magnetic resonance imaging (MRI) demonstrated that rats given a TBI had progressive atrophy of the motor cortices and degeneration of the corticospinal tracts compared with sham-injured rats. Immunofluorescence analyses revealed a progressive reduction in neurons, as well as increased phosphorylated transactive response DNA-binding protein 43 (TDP-43) and cytoplasmic TDP-43, in the motor cortex of rats given a TBI. Rats given a TBI also had fewer spinal cord motor neurons, increased expression of muscle atrophy markers, and altered muscle fiber contractile properties compared with sham-injured rats at 12 weeks, but not 1 week, post-injury. All of these changes occurred in the presence of persisting motor deficits. These findings resemble some of the pathological and functional abnormalities common in ALS and support the notion that TBI can result in a progressive neurodegenerative disease process pathologically bearing similarities to a motor neuron disease.</abstract><cop>United States</cop><pmid>27566977</pmid><doi>10.1093/cercor/bhw254</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1047-3211 |
ispartof | Cerebral cortex (New York, N.Y. 1991), 2017-09, Vol.27 (9), p.4503-4515 |
issn | 1047-3211 1460-2199 |
language | eng |
recordid | cdi_proquest_miscellaneous_1859719275 |
source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
subjects | Amyotrophic Lateral Sclerosis - physiopathology Animals Brain Injuries, Traumatic - complications Cytoplasm - metabolism Disease Models, Animal DNA-Binding Proteins - metabolism Male Motor Cortex - physiopathology Motor Neuron Disease - etiology Motor Neuron Disease - physiopathology Rats, Long-Evans Spinal Cord - physiopathology |
title | Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T20%3A47%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Traumatic%20Brain%20Injury%20Results%20in%20Cellular,%20Structural%20and%20Functional%20Changes%20Resembling%20Motor%20Neuron%20Disease&rft.jtitle=Cerebral%20cortex%20(New%20York,%20N.Y.%201991)&rft.au=Wright,%20David%20K&rft.date=2017-09-01&rft.volume=27&rft.issue=9&rft.spage=4503&rft.epage=4515&rft.pages=4503-4515&rft.issn=1047-3211&rft.eissn=1460-2199&rft_id=info:doi/10.1093/cercor/bhw254&rft_dat=%3Cproquest_cross%3E1859719275%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1859719275&rft_id=info:pmid/27566977&rfr_iscdi=true |