Bioavailability of chlorogenic acids in rats after acute ingestion of maté tea (Ilex paraguariensis) or 5-caffeoylquinic acid
Purpose Yerba maté is widely consumed in South America as different beverages, such as maté tea (roasted leaves) and chimarrão (green dried leaves), and linked to health benefits, mainly attributed to chlorogenic acids (CGAs). Health effects of CGAs depend on their bioavailability, but such data are...
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| Veröffentlicht in: | European journal of nutrition 2017-12, Vol.56 (8), p.2541-2556 |
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| creator | de Oliveira, Daniela Moura Sampaio, Geni Rodrigues Pinto, Carolina Bonin Catharino, Rodrigo Ramos Bastos, Deborah H. Markowicz |
| description | Purpose
Yerba maté is widely consumed in South America as different beverages, such as maté tea (roasted leaves) and
chimarrão
(green dried leaves), and linked to health benefits, mainly attributed to chlorogenic acids (CGAs). Health effects of CGAs depend on their bioavailability, but such data are scarce. The aim of this study was to investigate the distribution of CGAs and metabolites in tissues, hepatic and plasmatic kinetic profile and urinary excretion after ingestion of maté tea or 5-caffeoylquinic acid (5-CQA).
Methods
Wistar rats ingested maté tea (MT) or 5-CQA (ST) and were killed after 1.5 h for tissue distribution analysis (pilot study) or at 0.5, 1, 2, 4 and 8 h for liver and plasma kinetics (main experiment). Urine was collected in metabolic cages. Biological samples were analyzed by UPLC-DAD-MS with and without incubation with β-glucuronidase and sulfatase.
Results
CGAs and metabolites were detected in all tissues. Caffeic acid was the main compound in plasma up to 2 h after ingestion of maté tea, while 5-CQA predominated in ST group. Concentration of microbial metabolites increased 4 h after gavage and reached higher amounts in MT plasma and liver, when compared to ST group. Approximately 4.0 % of compounds ingested by MT and 3.3 % by ST were recovered in urine up to 8 h after the gavage.
Conclusion
The study confirms that not only absorption, but also metabolization of CGAs begins in stomach. There were differences in compounds formed from maté tea or isolated 5-CQA, showing that CGAs profile in food may influence qualitatively and quantitatively the metabolites formed in the body. |
| doi_str_mv | 10.1007/s00394-016-1290-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859717715</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859717715</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2871-81e5943ef71aa95a1f563695347ad92304680e145b5620f32bdd6966acf16ee93</originalsourceid><addsrcrecordid>eNp1kcFO3DAURa2qqNBpP4BNZakbWAT84tgeL1sEBQmpm7K23iTPg1EmHuyk6mz6P3wHP1aPBlCFxMrW87nX176MHYI4ASHMaRZC2qYSoCuorajgHTuARupK16Dev-yF2Wcfc74TQtRSwwe2XxsllVL2gP39HiL-xtDjIvRh3PDoeXvbxxSXNISWYxu6zMPAE46Zox8pldk0UpktKY8hDlvJCsfHBz4S8qOrnv7wNSZcTpgCDTnkYx4TV1WL3lPc9PdTeLb-xPY89pk-P60zdnNx_uvssrr--ePq7Nt11dZzA9UcSNlGkjeAaBWCV1pqq2RjsLO1FI2eC4JGLVR5rpf1ouu01RpbD5rIyhk72vmuU7yfSm63CrmlvseB4pQdzJU1YAyogn59hd7FKQ0lnQOrwTRiG2XGYEe1KeacyLt1CitMGwfCbctxu3JcKcdty3FQNF-enKfFiroXxXMbBah3QC5H5XvTf1e_6foP-DmZ8w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1961740594</pqid></control><display><type>article</type><title>Bioavailability of chlorogenic acids in rats after acute ingestion of maté tea (Ilex paraguariensis) or 5-caffeoylquinic acid</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>de Oliveira, Daniela Moura ; Sampaio, Geni Rodrigues ; Pinto, Carolina Bonin ; Catharino, Rodrigo Ramos ; Bastos, Deborah H. Markowicz</creator><creatorcontrib>de Oliveira, Daniela Moura ; Sampaio, Geni Rodrigues ; Pinto, Carolina Bonin ; Catharino, Rodrigo Ramos ; Bastos, Deborah H. Markowicz</creatorcontrib><description>Purpose
Yerba maté is widely consumed in South America as different beverages, such as maté tea (roasted leaves) and
chimarrão
(green dried leaves), and linked to health benefits, mainly attributed to chlorogenic acids (CGAs). Health effects of CGAs depend on their bioavailability, but such data are scarce. The aim of this study was to investigate the distribution of CGAs and metabolites in tissues, hepatic and plasmatic kinetic profile and urinary excretion after ingestion of maté tea or 5-caffeoylquinic acid (5-CQA).
Methods
Wistar rats ingested maté tea (MT) or 5-CQA (ST) and were killed after 1.5 h for tissue distribution analysis (pilot study) or at 0.5, 1, 2, 4 and 8 h for liver and plasma kinetics (main experiment). Urine was collected in metabolic cages. Biological samples were analyzed by UPLC-DAD-MS with and without incubation with β-glucuronidase and sulfatase.
Results
CGAs and metabolites were detected in all tissues. Caffeic acid was the main compound in plasma up to 2 h after ingestion of maté tea, while 5-CQA predominated in ST group. Concentration of microbial metabolites increased 4 h after gavage and reached higher amounts in MT plasma and liver, when compared to ST group. Approximately 4.0 % of compounds ingested by MT and 3.3 % by ST were recovered in urine up to 8 h after the gavage.
Conclusion
The study confirms that not only absorption, but also metabolization of CGAs begins in stomach. There were differences in compounds formed from maté tea or isolated 5-CQA, showing that CGAs profile in food may influence qualitatively and quantitatively the metabolites formed in the body.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-016-1290-1</identifier><identifier>PMID: 27535559</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acids ; Animals ; Beverages ; Bioavailability ; Biological Availability ; Caffeic acid ; Caffeic Acids - blood ; Chemistry ; Chemistry and Materials Science ; Chlorogenic Acid - administration & dosage ; Chlorogenic Acid - pharmacokinetics ; Excretion ; Food quality ; Ilex paraguariensis - chemistry ; Leaves ; Liver ; Metabolites ; Nutrition ; Original Contribution ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacokinetics ; Plant Leaves - chemistry ; Polyphenols - administration & dosage ; Polyphenols - pharmacokinetics ; Polyphenols - urine ; Quinic Acid - administration & dosage ; Quinic Acid - analogs & derivatives ; Quinic Acid - pharmacokinetics ; Rats ; Rats, Wistar ; South America ; Stomach ; Tea ; Teas, Herbal ; Urine</subject><ispartof>European journal of nutrition, 2017-12, Vol.56 (8), p.2541-2556</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>European Journal of Nutrition is a copyright of Springer, (2016). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2871-81e5943ef71aa95a1f563695347ad92304680e145b5620f32bdd6966acf16ee93</citedby><cites>FETCH-LOGICAL-c2871-81e5943ef71aa95a1f563695347ad92304680e145b5620f32bdd6966acf16ee93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-016-1290-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-016-1290-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27535559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Oliveira, Daniela Moura</creatorcontrib><creatorcontrib>Sampaio, Geni Rodrigues</creatorcontrib><creatorcontrib>Pinto, Carolina Bonin</creatorcontrib><creatorcontrib>Catharino, Rodrigo Ramos</creatorcontrib><creatorcontrib>Bastos, Deborah H. Markowicz</creatorcontrib><title>Bioavailability of chlorogenic acids in rats after acute ingestion of maté tea (Ilex paraguariensis) or 5-caffeoylquinic acid</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
Yerba maté is widely consumed in South America as different beverages, such as maté tea (roasted leaves) and
chimarrão
(green dried leaves), and linked to health benefits, mainly attributed to chlorogenic acids (CGAs). Health effects of CGAs depend on their bioavailability, but such data are scarce. The aim of this study was to investigate the distribution of CGAs and metabolites in tissues, hepatic and plasmatic kinetic profile and urinary excretion after ingestion of maté tea or 5-caffeoylquinic acid (5-CQA).
Methods
Wistar rats ingested maté tea (MT) or 5-CQA (ST) and were killed after 1.5 h for tissue distribution analysis (pilot study) or at 0.5, 1, 2, 4 and 8 h for liver and plasma kinetics (main experiment). Urine was collected in metabolic cages. Biological samples were analyzed by UPLC-DAD-MS with and without incubation with β-glucuronidase and sulfatase.
Results
CGAs and metabolites were detected in all tissues. Caffeic acid was the main compound in plasma up to 2 h after ingestion of maté tea, while 5-CQA predominated in ST group. Concentration of microbial metabolites increased 4 h after gavage and reached higher amounts in MT plasma and liver, when compared to ST group. Approximately 4.0 % of compounds ingested by MT and 3.3 % by ST were recovered in urine up to 8 h after the gavage.
Conclusion
The study confirms that not only absorption, but also metabolization of CGAs begins in stomach. There were differences in compounds formed from maté tea or isolated 5-CQA, showing that CGAs profile in food may influence qualitatively and quantitatively the metabolites formed in the body.</description><subject>Acids</subject><subject>Animals</subject><subject>Beverages</subject><subject>Bioavailability</subject><subject>Biological Availability</subject><subject>Caffeic acid</subject><subject>Caffeic Acids - blood</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chlorogenic Acid - administration & dosage</subject><subject>Chlorogenic Acid - pharmacokinetics</subject><subject>Excretion</subject><subject>Food quality</subject><subject>Ilex paraguariensis - chemistry</subject><subject>Leaves</subject><subject>Liver</subject><subject>Metabolites</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacokinetics</subject><subject>Plant Leaves - chemistry</subject><subject>Polyphenols - administration & dosage</subject><subject>Polyphenols - pharmacokinetics</subject><subject>Polyphenols - urine</subject><subject>Quinic Acid - administration & dosage</subject><subject>Quinic Acid - analogs & derivatives</subject><subject>Quinic Acid - pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>South America</subject><subject>Stomach</subject><subject>Tea</subject><subject>Teas, Herbal</subject><subject>Urine</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kcFO3DAURa2qqNBpP4BNZakbWAT84tgeL1sEBQmpm7K23iTPg1EmHuyk6mz6P3wHP1aPBlCFxMrW87nX176MHYI4ASHMaRZC2qYSoCuorajgHTuARupK16Dev-yF2Wcfc74TQtRSwwe2XxsllVL2gP39HiL-xtDjIvRh3PDoeXvbxxSXNISWYxu6zMPAE46Zox8pldk0UpktKY8hDlvJCsfHBz4S8qOrnv7wNSZcTpgCDTnkYx4TV1WL3lPc9PdTeLb-xPY89pk-P60zdnNx_uvssrr--ePq7Nt11dZzA9UcSNlGkjeAaBWCV1pqq2RjsLO1FI2eC4JGLVR5rpf1ouu01RpbD5rIyhk72vmuU7yfSm63CrmlvseB4pQdzJU1YAyogn59hd7FKQ0lnQOrwTRiG2XGYEe1KeacyLt1CitMGwfCbctxu3JcKcdty3FQNF-enKfFiroXxXMbBah3QC5H5XvTf1e_6foP-DmZ8w</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>de Oliveira, Daniela Moura</creator><creator>Sampaio, Geni Rodrigues</creator><creator>Pinto, Carolina Bonin</creator><creator>Catharino, Rodrigo Ramos</creator><creator>Bastos, Deborah H. Markowicz</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20171201</creationdate><title>Bioavailability of chlorogenic acids in rats after acute ingestion of maté tea (Ilex paraguariensis) or 5-caffeoylquinic acid</title><author>de Oliveira, Daniela Moura ; Sampaio, Geni Rodrigues ; Pinto, Carolina Bonin ; Catharino, Rodrigo Ramos ; Bastos, Deborah H. Markowicz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2871-81e5943ef71aa95a1f563695347ad92304680e145b5620f32bdd6966acf16ee93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acids</topic><topic>Animals</topic><topic>Beverages</topic><topic>Bioavailability</topic><topic>Biological Availability</topic><topic>Caffeic acid</topic><topic>Caffeic Acids - blood</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chlorogenic Acid - administration & dosage</topic><topic>Chlorogenic Acid - pharmacokinetics</topic><topic>Excretion</topic><topic>Food quality</topic><topic>Ilex paraguariensis - chemistry</topic><topic>Leaves</topic><topic>Liver</topic><topic>Metabolites</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacokinetics</topic><topic>Plant Leaves - chemistry</topic><topic>Polyphenols - administration & dosage</topic><topic>Polyphenols - pharmacokinetics</topic><topic>Polyphenols - urine</topic><topic>Quinic Acid - administration & dosage</topic><topic>Quinic Acid - analogs & derivatives</topic><topic>Quinic Acid - pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>South America</topic><topic>Stomach</topic><topic>Tea</topic><topic>Teas, Herbal</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Oliveira, Daniela Moura</creatorcontrib><creatorcontrib>Sampaio, Geni Rodrigues</creatorcontrib><creatorcontrib>Pinto, Carolina Bonin</creatorcontrib><creatorcontrib>Catharino, Rodrigo Ramos</creatorcontrib><creatorcontrib>Bastos, Deborah H. Markowicz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Oliveira, Daniela Moura</au><au>Sampaio, Geni Rodrigues</au><au>Pinto, Carolina Bonin</au><au>Catharino, Rodrigo Ramos</au><au>Bastos, Deborah H. Markowicz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioavailability of chlorogenic acids in rats after acute ingestion of maté tea (Ilex paraguariensis) or 5-caffeoylquinic acid</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>56</volume><issue>8</issue><spage>2541</spage><epage>2556</epage><pages>2541-2556</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
Yerba maté is widely consumed in South America as different beverages, such as maté tea (roasted leaves) and
chimarrão
(green dried leaves), and linked to health benefits, mainly attributed to chlorogenic acids (CGAs). Health effects of CGAs depend on their bioavailability, but such data are scarce. The aim of this study was to investigate the distribution of CGAs and metabolites in tissues, hepatic and plasmatic kinetic profile and urinary excretion after ingestion of maté tea or 5-caffeoylquinic acid (5-CQA).
Methods
Wistar rats ingested maté tea (MT) or 5-CQA (ST) and were killed after 1.5 h for tissue distribution analysis (pilot study) or at 0.5, 1, 2, 4 and 8 h for liver and plasma kinetics (main experiment). Urine was collected in metabolic cages. Biological samples were analyzed by UPLC-DAD-MS with and without incubation with β-glucuronidase and sulfatase.
Results
CGAs and metabolites were detected in all tissues. Caffeic acid was the main compound in plasma up to 2 h after ingestion of maté tea, while 5-CQA predominated in ST group. Concentration of microbial metabolites increased 4 h after gavage and reached higher amounts in MT plasma and liver, when compared to ST group. Approximately 4.0 % of compounds ingested by MT and 3.3 % by ST were recovered in urine up to 8 h after the gavage.
Conclusion
The study confirms that not only absorption, but also metabolization of CGAs begins in stomach. There were differences in compounds formed from maté tea or isolated 5-CQA, showing that CGAs profile in food may influence qualitatively and quantitatively the metabolites formed in the body.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27535559</pmid><doi>10.1007/s00394-016-1290-1</doi><tpages>16</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acids Animals Beverages Bioavailability Biological Availability Caffeic acid Caffeic Acids - blood Chemistry Chemistry and Materials Science Chlorogenic Acid - administration & dosage Chlorogenic Acid - pharmacokinetics Excretion Food quality Ilex paraguariensis - chemistry Leaves Liver Metabolites Nutrition Original Contribution Plant Extracts - administration & dosage Plant Extracts - pharmacokinetics Plant Leaves - chemistry Polyphenols - administration & dosage Polyphenols - pharmacokinetics Polyphenols - urine Quinic Acid - administration & dosage Quinic Acid - analogs & derivatives Quinic Acid - pharmacokinetics Rats Rats, Wistar South America Stomach Tea Teas, Herbal Urine |
| title | Bioavailability of chlorogenic acids in rats after acute ingestion of maté tea (Ilex paraguariensis) or 5-caffeoylquinic acid |
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