Evaluation of interstitial cells of Cajal in patients with severe colonic inertia requiring surgery: a clinical‐pathological study
Aim Subtotal colectomy is the treatment of last resort in patients with severe colonic inertia (SCI) refractory to laxatives. Some studies have reported hypoplasia of the interstitial cells of Cajal (ICC) using a semi‐quantitative analysis. The aims of this study were first to investigate if semi‐qu...
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| Veröffentlicht in: | Colorectal disease 2017-05, Vol.19 (5), p.462-467 |
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| creator | Cohen, M. Cazals‐Hatem, D. Duboc, H. Sabate, J.‐M. Msika, S. Slove, A. L. Panis, Y. Coffin, B. |
| description | Aim
Subtotal colectomy is the treatment of last resort in patients with severe colonic inertia (SCI) refractory to laxatives. Some studies have reported hypoplasia of the interstitial cells of Cajal (ICC) using a semi‐quantitative analysis. The aims of this study were first to investigate if semi‐quantitative analysis or morphometry is better at the quantification of colonic ICC and second to determine whether there is a relationship between the number of ICC and the severity of constipation.
Method
Clinical and pathological data from patients with subtotal colectomy for SCI were collected. Quantification of ICC using CD117 immunohistochemistry and morphometric methods was performed at three different colonic sites in patients and controls.
Results
Twenty patients had a colectomy for SCI. All were considered to have failed maximal medical treatment and 45% were hospitalized at least once for colonic obstruction due to faecaloma. Using a semi‐quantitative methodology, 30% of patients displayed ICC hypoplasia ( |
| doi_str_mv | 10.1111/codi.13511 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859717293</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1920470532</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3571-109205752dcff6c6a3fcae79b991e712be55e6fc6c3072d6e69c9fbe3d2d86e83</originalsourceid><addsrcrecordid>eNp9kUFPHCEUx4mpUWt78QMYkl5Mk7E8cGDozWxta2LipT0TlnmzsmGHFWbW7M2DH6CfsZ-kjGs99FAu8OD3fnnkT8gJsHMo65OLrT8HUQPskSO4kKICAc2b5zOvGg3skLzNeckYSAXNATnkSnLFeHNEnq42Nox28LGnsaO-HzDlwQ_eBuowhDzdzuyylL6n6wJiP2T64Ic7mnGDCamLIfbelXdMpY8mvB998v2C5jEtMG0_U0td8IWx4ffjryK5Ky2LqaR5GNvtO7Lf2ZDx_ct-TH5-vfox-17d3H67nl3eVE7UCipgmrNa1bx1XSedtKJzFpWeaw2ogM-xrlF2TjrBFG8lSu10N0fR8raR2IhjcrbzrlO8HzEPZuXz9EvbYxyzgabWChTXoqAf_kGXcUx9mc5AmeJCsVrwQn3cUS7FnBN2Zp38yqatAWambMyUjXnOpsCnL8pxvsL2Ff0bRgFgBzz4gNv_qMzs9sv1TvoHcgScwA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1920470532</pqid></control><display><type>article</type><title>Evaluation of interstitial cells of Cajal in patients with severe colonic inertia requiring surgery: a clinical‐pathological study</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Cohen, M. ; Cazals‐Hatem, D. ; Duboc, H. ; Sabate, J.‐M. ; Msika, S. ; Slove, A. L. ; Panis, Y. ; Coffin, B.</creator><creatorcontrib>Cohen, M. ; Cazals‐Hatem, D. ; Duboc, H. ; Sabate, J.‐M. ; Msika, S. ; Slove, A. L. ; Panis, Y. ; Coffin, B.</creatorcontrib><description>Aim
Subtotal colectomy is the treatment of last resort in patients with severe colonic inertia (SCI) refractory to laxatives. Some studies have reported hypoplasia of the interstitial cells of Cajal (ICC) using a semi‐quantitative analysis. The aims of this study were first to investigate if semi‐quantitative analysis or morphometry is better at the quantification of colonic ICC and second to determine whether there is a relationship between the number of ICC and the severity of constipation.
Method
Clinical and pathological data from patients with subtotal colectomy for SCI were collected. Quantification of ICC using CD117 immunohistochemistry and morphometric methods was performed at three different colonic sites in patients and controls.
Results
Twenty patients had a colectomy for SCI. All were considered to have failed maximal medical treatment and 45% were hospitalized at least once for colonic obstruction due to faecaloma. Using a semi‐quantitative methodology, 30% of patients displayed ICC hypoplasia (< 7 per high power field) and all controls had normal ICC. Using morphometry, the percentage of colonic ICC was significantly less in patients compared with controls with no significant differences between the ascending, transverse and descending colonic segments. Overall 60% of patients had ICC hypoplasia (< 1% vs 20% of controls, P = 0.009). The severity of constipation was not related to the quantity of ICC.
Conclusion
In patients with SCI, morphometric analysis is more sensitive than semi‐quantitative analysis in the detection of ICC hypoplasia. The severity of constipation was not related to the quantity of ICC.</description><identifier>ISSN: 1462-8910</identifier><identifier>EISSN: 1463-1318</identifier><identifier>DOI: 10.1111/codi.13511</identifier><identifier>PMID: 27627028</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Colectomy ; Colon ; Colon - cytology ; colonic inertia ; Constipation ; Constipation - pathology ; Constipation - surgery ; Female ; Humans ; Hypoplasia ; Immunohistochemistry ; Interstitial cells ; Interstitial cells of Cajal ; Interstitial Cells of Cajal - pathology ; Laxatives ; Male ; Medical treatment ; Middle Aged ; Morphometry ; Proto-Oncogene Proteins c-kit - analysis ; Quantitative analysis ; Retrospective Studies ; Severity of Illness Index ; Surgery</subject><ispartof>Colorectal disease, 2017-05, Vol.19 (5), p.462-467</ispartof><rights>Colorectal Disease © 2016 The Association of Coloproctology of Great Britain and Ireland</rights><rights>Colorectal Disease © 2016 The Association of Coloproctology of Great Britain and Ireland.</rights><rights>Copyright © 2017 The Association of Coloproctology of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3571-109205752dcff6c6a3fcae79b991e712be55e6fc6c3072d6e69c9fbe3d2d86e83</citedby><cites>FETCH-LOGICAL-c3571-109205752dcff6c6a3fcae79b991e712be55e6fc6c3072d6e69c9fbe3d2d86e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcodi.13511$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcodi.13511$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27627028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, M.</creatorcontrib><creatorcontrib>Cazals‐Hatem, D.</creatorcontrib><creatorcontrib>Duboc, H.</creatorcontrib><creatorcontrib>Sabate, J.‐M.</creatorcontrib><creatorcontrib>Msika, S.</creatorcontrib><creatorcontrib>Slove, A. L.</creatorcontrib><creatorcontrib>Panis, Y.</creatorcontrib><creatorcontrib>Coffin, B.</creatorcontrib><title>Evaluation of interstitial cells of Cajal in patients with severe colonic inertia requiring surgery: a clinical‐pathological study</title><title>Colorectal disease</title><addtitle>Colorectal Dis</addtitle><description>Aim
Subtotal colectomy is the treatment of last resort in patients with severe colonic inertia (SCI) refractory to laxatives. Some studies have reported hypoplasia of the interstitial cells of Cajal (ICC) using a semi‐quantitative analysis. The aims of this study were first to investigate if semi‐quantitative analysis or morphometry is better at the quantification of colonic ICC and second to determine whether there is a relationship between the number of ICC and the severity of constipation.
Method
Clinical and pathological data from patients with subtotal colectomy for SCI were collected. Quantification of ICC using CD117 immunohistochemistry and morphometric methods was performed at three different colonic sites in patients and controls.
Results
Twenty patients had a colectomy for SCI. All were considered to have failed maximal medical treatment and 45% were hospitalized at least once for colonic obstruction due to faecaloma. Using a semi‐quantitative methodology, 30% of patients displayed ICC hypoplasia (< 7 per high power field) and all controls had normal ICC. Using morphometry, the percentage of colonic ICC was significantly less in patients compared with controls with no significant differences between the ascending, transverse and descending colonic segments. Overall 60% of patients had ICC hypoplasia (< 1% vs 20% of controls, P = 0.009). The severity of constipation was not related to the quantity of ICC.
Conclusion
In patients with SCI, morphometric analysis is more sensitive than semi‐quantitative analysis in the detection of ICC hypoplasia. The severity of constipation was not related to the quantity of ICC.</description><subject>Adult</subject><subject>Colectomy</subject><subject>Colon</subject><subject>Colon - cytology</subject><subject>colonic inertia</subject><subject>Constipation</subject><subject>Constipation - pathology</subject><subject>Constipation - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoplasia</subject><subject>Immunohistochemistry</subject><subject>Interstitial cells</subject><subject>Interstitial cells of Cajal</subject><subject>Interstitial Cells of Cajal - pathology</subject><subject>Laxatives</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Morphometry</subject><subject>Proto-Oncogene Proteins c-kit - analysis</subject><subject>Quantitative analysis</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Surgery</subject><issn>1462-8910</issn><issn>1463-1318</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFPHCEUx4mpUWt78QMYkl5Mk7E8cGDozWxta2LipT0TlnmzsmGHFWbW7M2DH6CfsZ-kjGs99FAu8OD3fnnkT8gJsHMo65OLrT8HUQPskSO4kKICAc2b5zOvGg3skLzNeckYSAXNATnkSnLFeHNEnq42Nox28LGnsaO-HzDlwQ_eBuowhDzdzuyylL6n6wJiP2T64Ic7mnGDCamLIfbelXdMpY8mvB998v2C5jEtMG0_U0td8IWx4ffjryK5Ky2LqaR5GNvtO7Lf2ZDx_ct-TH5-vfox-17d3H67nl3eVE7UCipgmrNa1bx1XSedtKJzFpWeaw2ogM-xrlF2TjrBFG8lSu10N0fR8raR2IhjcrbzrlO8HzEPZuXz9EvbYxyzgabWChTXoqAf_kGXcUx9mc5AmeJCsVrwQn3cUS7FnBN2Zp38yqatAWambMyUjXnOpsCnL8pxvsL2Ff0bRgFgBzz4gNv_qMzs9sv1TvoHcgScwA</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Cohen, M.</creator><creator>Cazals‐Hatem, D.</creator><creator>Duboc, H.</creator><creator>Sabate, J.‐M.</creator><creator>Msika, S.</creator><creator>Slove, A. L.</creator><creator>Panis, Y.</creator><creator>Coffin, B.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201705</creationdate><title>Evaluation of interstitial cells of Cajal in patients with severe colonic inertia requiring surgery: a clinical‐pathological study</title><author>Cohen, M. ; Cazals‐Hatem, D. ; Duboc, H. ; Sabate, J.‐M. ; Msika, S. ; Slove, A. L. ; Panis, Y. ; Coffin, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3571-109205752dcff6c6a3fcae79b991e712be55e6fc6c3072d6e69c9fbe3d2d86e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Colectomy</topic><topic>Colon</topic><topic>Colon - cytology</topic><topic>colonic inertia</topic><topic>Constipation</topic><topic>Constipation - pathology</topic><topic>Constipation - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoplasia</topic><topic>Immunohistochemistry</topic><topic>Interstitial cells</topic><topic>Interstitial cells of Cajal</topic><topic>Interstitial Cells of Cajal - pathology</topic><topic>Laxatives</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Morphometry</topic><topic>Proto-Oncogene Proteins c-kit - analysis</topic><topic>Quantitative analysis</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, M.</creatorcontrib><creatorcontrib>Cazals‐Hatem, D.</creatorcontrib><creatorcontrib>Duboc, H.</creatorcontrib><creatorcontrib>Sabate, J.‐M.</creatorcontrib><creatorcontrib>Msika, S.</creatorcontrib><creatorcontrib>Slove, A. L.</creatorcontrib><creatorcontrib>Panis, Y.</creatorcontrib><creatorcontrib>Coffin, B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, M.</au><au>Cazals‐Hatem, D.</au><au>Duboc, H.</au><au>Sabate, J.‐M.</au><au>Msika, S.</au><au>Slove, A. L.</au><au>Panis, Y.</au><au>Coffin, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of interstitial cells of Cajal in patients with severe colonic inertia requiring surgery: a clinical‐pathological study</atitle><jtitle>Colorectal disease</jtitle><addtitle>Colorectal Dis</addtitle><date>2017-05</date><risdate>2017</risdate><volume>19</volume><issue>5</issue><spage>462</spage><epage>467</epage><pages>462-467</pages><issn>1462-8910</issn><eissn>1463-1318</eissn><abstract>Aim
Subtotal colectomy is the treatment of last resort in patients with severe colonic inertia (SCI) refractory to laxatives. Some studies have reported hypoplasia of the interstitial cells of Cajal (ICC) using a semi‐quantitative analysis. The aims of this study were first to investigate if semi‐quantitative analysis or morphometry is better at the quantification of colonic ICC and second to determine whether there is a relationship between the number of ICC and the severity of constipation.
Method
Clinical and pathological data from patients with subtotal colectomy for SCI were collected. Quantification of ICC using CD117 immunohistochemistry and morphometric methods was performed at three different colonic sites in patients and controls.
Results
Twenty patients had a colectomy for SCI. All were considered to have failed maximal medical treatment and 45% were hospitalized at least once for colonic obstruction due to faecaloma. Using a semi‐quantitative methodology, 30% of patients displayed ICC hypoplasia (< 7 per high power field) and all controls had normal ICC. Using morphometry, the percentage of colonic ICC was significantly less in patients compared with controls with no significant differences between the ascending, transverse and descending colonic segments. Overall 60% of patients had ICC hypoplasia (< 1% vs 20% of controls, P = 0.009). The severity of constipation was not related to the quantity of ICC.
Conclusion
In patients with SCI, morphometric analysis is more sensitive than semi‐quantitative analysis in the detection of ICC hypoplasia. The severity of constipation was not related to the quantity of ICC.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27627028</pmid><doi>10.1111/codi.13511</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Colectomy Colon Colon - cytology colonic inertia Constipation Constipation - pathology Constipation - surgery Female Humans Hypoplasia Immunohistochemistry Interstitial cells Interstitial cells of Cajal Interstitial Cells of Cajal - pathology Laxatives Male Medical treatment Middle Aged Morphometry Proto-Oncogene Proteins c-kit - analysis Quantitative analysis Retrospective Studies Severity of Illness Index Surgery |
| title | Evaluation of interstitial cells of Cajal in patients with severe colonic inertia requiring surgery: a clinical‐pathological study |
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