No Association of Lower Hippocampal Volume With Alzheimer’s Disease Pathology in Late-Life Depression
Objective:Hippocampal volume is commonly decreased in late-life depression. According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal volume in late-life depression is associated with neurodegenerative changes. The purpose of this prospective study was to examine wh...
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| Veröffentlicht in: | The American journal of psychiatry 2017-03, Vol.174 (3), p.237-245 |
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| creator | De Winter, François-Laurent Emsell, Louise Bouckaert, Filip Claes, Lene Jain, Saurabh Farrar, Gill Billiet, Thibo Evers, Stephan Van den Stock, Jan Sienaert, Pascal Obbels, Jasmien Sunaert, Stefan Adamczuk, Katarzyna Vandenberghe, Rik Van Laere, Koen Vandenbulcke, Mathieu |
| description | Objective:Hippocampal volume is commonly decreased in late-life depression. According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal volume in late-life depression is associated with neurodegenerative changes. The purpose of this prospective study was to examine whether lower hippocampal volume in late-life depression is associated with Alzheimer’s disease pathology.Method:Of 108 subjects who participated, complete, good-quality data sets were available for 100: 48 currently depressed older adults and 52 age- and gender-matched healthy comparison subjects who underwent structural MRI, [18F]flutemetamol amyloid positron emission tomography imaging, apolipoprotein E genotyping, and neuropsychological assessment. Hippocampal volumes were defined manually and normalized for total intracranial volume. Amyloid binding was quantified using the standardized uptake value ratio in one cortical composite volume of interest. The authors investigated group differences in hippocampal volume (both including and excluding amyloid-positive participants), group differences in amyloid uptake and in the proportion of positive amyloid scans, and the association between hippocampal volume and cortical amyloid uptake.Results:A significant difference was observed in mean normalized total hippocampal volume between patients and comparison subjects, but there were no group differences in cortical amyloid uptake or proportion of amyloid-positive subjects. The difference in hippocampal volume remained significant after the amyloid-positive subjects were excluded. There was no association between hippocampal volume and amyloid uptake in either patients or comparison subjects.Conclusions:Lower hippocampal volume was not related to amyloid pathology in this sample of patients with late-life depression. These data counter the common belief that changes in hippocampal volume in late-life depression are due to prodromal Alzheimer’s disease. |
| doi_str_mv | 10.1176/appi.ajp.2016.16030319 |
| format | Article |
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According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal volume in late-life depression is associated with neurodegenerative changes. The purpose of this prospective study was to examine whether lower hippocampal volume in late-life depression is associated with Alzheimer’s disease pathology.Method:Of 108 subjects who participated, complete, good-quality data sets were available for 100: 48 currently depressed older adults and 52 age- and gender-matched healthy comparison subjects who underwent structural MRI, [18F]flutemetamol amyloid positron emission tomography imaging, apolipoprotein E genotyping, and neuropsychological assessment. Hippocampal volumes were defined manually and normalized for total intracranial volume. Amyloid binding was quantified using the standardized uptake value ratio in one cortical composite volume of interest. The authors investigated group differences in hippocampal volume (both including and excluding amyloid-positive participants), group differences in amyloid uptake and in the proportion of positive amyloid scans, and the association between hippocampal volume and cortical amyloid uptake.Results:A significant difference was observed in mean normalized total hippocampal volume between patients and comparison subjects, but there were no group differences in cortical amyloid uptake or proportion of amyloid-positive subjects. The difference in hippocampal volume remained significant after the amyloid-positive subjects were excluded. There was no association between hippocampal volume and amyloid uptake in either patients or comparison subjects.Conclusions:Lower hippocampal volume was not related to amyloid pathology in this sample of patients with late-life depression. These data counter the common belief that changes in hippocampal volume in late-life depression are due to prodromal Alzheimer’s disease.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.2016.16030319</identifier><identifier>PMID: 27539488</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>United States: American Psychiatric Association</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - pathology ; Alzheimer's disease ; Amyloid - metabolism ; Aniline Compounds ; Atrophy ; Belgium ; Benzothiazoles ; Brain research ; Cerebral Cortex - pathology ; Depressive Disorder - pathology ; Female ; Fluorine Radioisotopes ; Hippocampus - pathology ; Humans ; Image Interpretation, Computer-Assisted ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Mental depression ; Middle Aged ; Neuropsychology ; Organ Size ; Positron-Emission Tomography ; Prodromal Symptoms ; Psychopathology ; Reference Values ; Statistics as Topic</subject><ispartof>The American journal of psychiatry, 2017-03, Vol.174 (3), p.237-245</ispartof><rights>Copyright © 2017 by the American Psychiatric Association 2017</rights><rights>Copyright American Psychiatric Publishing, Inc. Mar 1, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a431t-148d7756c1e312758d4a3b04c6a2287899018fd13854d4ae5ddb846013d6f1bc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.2016.16030319$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.2016.16030319$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2855,21626,21627,21628,27924,27925,77794,77799</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27539488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Winter, François-Laurent</creatorcontrib><creatorcontrib>Emsell, Louise</creatorcontrib><creatorcontrib>Bouckaert, Filip</creatorcontrib><creatorcontrib>Claes, Lene</creatorcontrib><creatorcontrib>Jain, Saurabh</creatorcontrib><creatorcontrib>Farrar, Gill</creatorcontrib><creatorcontrib>Billiet, Thibo</creatorcontrib><creatorcontrib>Evers, Stephan</creatorcontrib><creatorcontrib>Van den Stock, Jan</creatorcontrib><creatorcontrib>Sienaert, Pascal</creatorcontrib><creatorcontrib>Obbels, Jasmien</creatorcontrib><creatorcontrib>Sunaert, Stefan</creatorcontrib><creatorcontrib>Adamczuk, Katarzyna</creatorcontrib><creatorcontrib>Vandenberghe, Rik</creatorcontrib><creatorcontrib>Van Laere, Koen</creatorcontrib><creatorcontrib>Vandenbulcke, Mathieu</creatorcontrib><title>No Association of Lower Hippocampal Volume With Alzheimer’s Disease Pathology in Late-Life Depression</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>Objective:Hippocampal volume is commonly decreased in late-life depression. According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal volume in late-life depression is associated with neurodegenerative changes. The purpose of this prospective study was to examine whether lower hippocampal volume in late-life depression is associated with Alzheimer’s disease pathology.Method:Of 108 subjects who participated, complete, good-quality data sets were available for 100: 48 currently depressed older adults and 52 age- and gender-matched healthy comparison subjects who underwent structural MRI, [18F]flutemetamol amyloid positron emission tomography imaging, apolipoprotein E genotyping, and neuropsychological assessment. Hippocampal volumes were defined manually and normalized for total intracranial volume. Amyloid binding was quantified using the standardized uptake value ratio in one cortical composite volume of interest. The authors investigated group differences in hippocampal volume (both including and excluding amyloid-positive participants), group differences in amyloid uptake and in the proportion of positive amyloid scans, and the association between hippocampal volume and cortical amyloid uptake.Results:A significant difference was observed in mean normalized total hippocampal volume between patients and comparison subjects, but there were no group differences in cortical amyloid uptake or proportion of amyloid-positive subjects. The difference in hippocampal volume remained significant after the amyloid-positive subjects were excluded. There was no association between hippocampal volume and amyloid uptake in either patients or comparison subjects.Conclusions:Lower hippocampal volume was not related to amyloid pathology in this sample of patients with late-life depression. These data counter the common belief that changes in hippocampal volume in late-life depression are due to prodromal Alzheimer’s disease.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Amyloid - metabolism</subject><subject>Aniline Compounds</subject><subject>Atrophy</subject><subject>Belgium</subject><subject>Benzothiazoles</subject><subject>Brain research</subject><subject>Cerebral Cortex - pathology</subject><subject>Depressive Disorder - pathology</subject><subject>Female</subject><subject>Fluorine Radioisotopes</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Neuropsychology</subject><subject>Organ Size</subject><subject>Positron-Emission Tomography</subject><subject>Prodromal Symptoms</subject><subject>Psychopathology</subject><subject>Reference Values</subject><subject>Statistics as Topic</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAQxy0EokvhFSpLXLhk64njjxxXLdBKUemBr5vlTSZdr5K1sROhcuI1eD2eBG-3BYlDT5bl3_w9Mz9CToAtAZQ8tSG4pd2GZclALkEyzjjUT8gCBBeFKkv9lCwYY2VRC_71iLxIaZuvjKvyOTkqleB1pfWC3Fx5ukrJt85Ozu-o72njv2OkFy4E39ox2IF-9sM8Iv3ipg1dDT826EaMv3_-SvTcJbQJ6bWdNn7wN7fU7WhjJywa1yM9xxAxpRz8kjzr7ZDw1f15TD69e_vx7KJoPry_PFs1ha04TAVUulNKyBaQQ-5Sd5Xla1a10uaRlK5rBrrvgGtR5ScUXbfWlWTAO9nDuuXH5M0hN0T_bcY0mdGlFofB7tDPyYAWtQLJOWT09X_o1s9xl7vLlBKKiVKITMkD1UafUsTehOhGG28NMLNXYfYqTFZh9irMg4pceHIfP69H7P6WPew-A_wA3AX8-_vx2D_c0pbo</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>De Winter, François-Laurent</creator><creator>Emsell, Louise</creator><creator>Bouckaert, Filip</creator><creator>Claes, Lene</creator><creator>Jain, Saurabh</creator><creator>Farrar, Gill</creator><creator>Billiet, Thibo</creator><creator>Evers, Stephan</creator><creator>Van den Stock, Jan</creator><creator>Sienaert, Pascal</creator><creator>Obbels, Jasmien</creator><creator>Sunaert, Stefan</creator><creator>Adamczuk, Katarzyna</creator><creator>Vandenberghe, Rik</creator><creator>Van Laere, Koen</creator><creator>Vandenbulcke, Mathieu</creator><general>American Psychiatric Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>No Association of Lower Hippocampal Volume With Alzheimer’s Disease Pathology in Late-Life Depression</title><author>De Winter, François-Laurent ; 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According to the depression-as-late-life-neuropsychiatric-disorder model, lower hippocampal volume in late-life depression is associated with neurodegenerative changes. The purpose of this prospective study was to examine whether lower hippocampal volume in late-life depression is associated with Alzheimer’s disease pathology.Method:Of 108 subjects who participated, complete, good-quality data sets were available for 100: 48 currently depressed older adults and 52 age- and gender-matched healthy comparison subjects who underwent structural MRI, [18F]flutemetamol amyloid positron emission tomography imaging, apolipoprotein E genotyping, and neuropsychological assessment. Hippocampal volumes were defined manually and normalized for total intracranial volume. Amyloid binding was quantified using the standardized uptake value ratio in one cortical composite volume of interest. The authors investigated group differences in hippocampal volume (both including and excluding amyloid-positive participants), group differences in amyloid uptake and in the proportion of positive amyloid scans, and the association between hippocampal volume and cortical amyloid uptake.Results:A significant difference was observed in mean normalized total hippocampal volume between patients and comparison subjects, but there were no group differences in cortical amyloid uptake or proportion of amyloid-positive subjects. The difference in hippocampal volume remained significant after the amyloid-positive subjects were excluded. There was no association between hippocampal volume and amyloid uptake in either patients or comparison subjects.Conclusions:Lower hippocampal volume was not related to amyloid pathology in this sample of patients with late-life depression. These data counter the common belief that changes in hippocampal volume in late-life depression are due to prodromal Alzheimer’s disease.</abstract><cop>United States</cop><pub>American Psychiatric Association</pub><pmid>27539488</pmid><doi>10.1176/appi.ajp.2016.16030319</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - pathology Alzheimer's disease Amyloid - metabolism Aniline Compounds Atrophy Belgium Benzothiazoles Brain research Cerebral Cortex - pathology Depressive Disorder - pathology Female Fluorine Radioisotopes Hippocampus - pathology Humans Image Interpretation, Computer-Assisted Imaging, Three-Dimensional Magnetic Resonance Imaging Male Medical imaging Mental depression Middle Aged Neuropsychology Organ Size Positron-Emission Tomography Prodromal Symptoms Psychopathology Reference Values Statistics as Topic |
| title | No Association of Lower Hippocampal Volume With Alzheimer’s Disease Pathology in Late-Life Depression |
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