MRS of pilocytic astrocytoma: The peak at 2 ppm may not be NAA
Purpose To determine whether the chemical shift of residual N‐acetylaspartate (NAA) signal in pilocytic astrocytomas (PA) is consistent with the position of the NAA peak in controls. Methods MR spectra from 27 pediatric World Health Organization (WHO) grade I pilocytic astrocytoma patients, fifteen...
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| Veröffentlicht in: | Magnetic resonance in medicine 2017-08, Vol.78 (2), p.452-456 |
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| container_title | Magnetic resonance in medicine |
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| creator | Tamrazi, Benita Nelson, Marvin D. Blüml, Stefan |
| description | Purpose
To determine whether the chemical shift of residual N‐acetylaspartate (NAA) signal in pilocytic astrocytomas (PA) is consistent with the position of the NAA peak in controls.
Methods
MR spectra from 27 pediatric World Health Organization (WHO) grade I pilocytic astrocytoma patients, fifteen patients with WHO grade II and high‐grade (III–IV) astrocytomas, and 36 controls were analyzed. All spectra were acquired with a short echo time (35 ms), single voxel point‐resolved spectroscopy sequence on clinical 3 tesla scanners. Fully automated LCModel software was used for processing, which included the fitting of peak positions for NAA and creatine (Cr).
Results
The chemical shift difference between the NAA and Cr peaks was significantly smaller (by 0.016 ± 0.005 parts per million, P |
| doi_str_mv | 10.1002/mrm.26374 |
| format | Article |
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To determine whether the chemical shift of residual N‐acetylaspartate (NAA) signal in pilocytic astrocytomas (PA) is consistent with the position of the NAA peak in controls.
Methods
MR spectra from 27 pediatric World Health Organization (WHO) grade I pilocytic astrocytoma patients, fifteen patients with WHO grade II and high‐grade (III–IV) astrocytomas, and 36 controls were analyzed. All spectra were acquired with a short echo time (35 ms), single voxel point‐resolved spectroscopy sequence on clinical 3 tesla scanners. Fully automated LCModel software was used for processing, which included the fitting of peak positions for NAA and creatine (Cr).
Results
The chemical shift difference between the NAA and Cr peaks was significantly smaller (by 0.016 ± 0.005 parts per million, P < 1e–10) in PAs than in controls and was also smaller than what was observed in infiltrative astrocytomas.
Conclusion
The chemical shift position of the residual NAA peak in PAs is not consistent with NAA. The signal likely originates from an N‐acetyl group of one or more other chemicals such as N‐acetylated sugars. Magn Reson Med 78:452–456, 2017. © 2016 International Society for Magnetic Resonance in Medicine</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.26374</identifier><identifier>PMID: 27529659</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - analysis ; Aspartic Acid - chemistry ; Aspartic Acid - metabolism ; Astrocytoma - diagnostic imaging ; Brain - diagnostic imaging ; Brain Neoplasms - diagnostic imaging ; Child ; Child, Preschool ; Humans ; Infant ; Magnetic Resonance Imaging - methods ; MR spectroscopy ; N‐acetylaspartate ; Pilocytic astrocytoma</subject><ispartof>Magnetic resonance in medicine, 2017-08, Vol.78 (2), p.452-456</ispartof><rights>2016 International Society for Magnetic Resonance in Medicine</rights><rights>2016 International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2414-cf401b01478d51d20b70f98a3140d3a822d6b57ef06d83672d25978b28ac3edc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.26374$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.26374$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27529659$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamrazi, Benita</creatorcontrib><creatorcontrib>Nelson, Marvin D.</creatorcontrib><creatorcontrib>Blüml, Stefan</creatorcontrib><title>MRS of pilocytic astrocytoma: The peak at 2 ppm may not be NAA</title><title>Magnetic resonance in medicine</title><addtitle>Magn Reson Med</addtitle><description>Purpose
To determine whether the chemical shift of residual N‐acetylaspartate (NAA) signal in pilocytic astrocytomas (PA) is consistent with the position of the NAA peak in controls.
Methods
MR spectra from 27 pediatric World Health Organization (WHO) grade I pilocytic astrocytoma patients, fifteen patients with WHO grade II and high‐grade (III–IV) astrocytomas, and 36 controls were analyzed. All spectra were acquired with a short echo time (35 ms), single voxel point‐resolved spectroscopy sequence on clinical 3 tesla scanners. Fully automated LCModel software was used for processing, which included the fitting of peak positions for NAA and creatine (Cr).
Results
The chemical shift difference between the NAA and Cr peaks was significantly smaller (by 0.016 ± 0.005 parts per million, P < 1e–10) in PAs than in controls and was also smaller than what was observed in infiltrative astrocytomas.
Conclusion
The chemical shift position of the residual NAA peak in PAs is not consistent with NAA. The signal likely originates from an N‐acetyl group of one or more other chemicals such as N‐acetylated sugars. Magn Reson Med 78:452–456, 2017. © 2016 International Society for Magnetic Resonance in Medicine</description><subject>Adolescent</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - analysis</subject><subject>Aspartic Acid - chemistry</subject><subject>Aspartic Acid - metabolism</subject><subject>Astrocytoma - diagnostic imaging</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Humans</subject><subject>Infant</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>MR spectroscopy</subject><subject>N‐acetylaspartate</subject><subject>Pilocytic astrocytoma</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMlOwzAURS0EoqWw4AeQl2zSPg-JHVZUFZPUglTK2nJsRwTiJmQQyo4tv8mXkA6weld6R1e6B6FzAmMCQCe-8mMaMcEP0JCElAY0jPkhGoLgEDAS8wE6qes3AIhjwY_RgIqQxlEYD9H1YvmMixSXWV6YrskM1nVTbWLh9RVevTpcOv2OdYPpz9d3WXrsdYfXRYMThx-n01N0lOq8dmf7O0Ivtzer2X0wf7p7mE3ngaGc8MCkHEgChAtpQ2IpJALSWGpGOFimJaU2SkLhUoisZJGgtt8gZEKlNsxZw0boctdbVsVH6-pG-aw2Ls_12hVtrYjsecIjBj16sUfbxDuryirzuurU3-oemOyAzyx33f-fgNroVL1OtdWpFsvFNrBfYNBlGw</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Tamrazi, Benita</creator><creator>Nelson, Marvin D.</creator><creator>Blüml, Stefan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>MRS of pilocytic astrocytoma: The peak at 2 ppm may not be NAA</title><author>Tamrazi, Benita ; Nelson, Marvin D. ; Blüml, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2414-cf401b01478d51d20b70f98a3140d3a822d6b57ef06d83672d25978b28ac3edc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - analysis</topic><topic>Aspartic Acid - chemistry</topic><topic>Aspartic Acid - metabolism</topic><topic>Astrocytoma - diagnostic imaging</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Humans</topic><topic>Infant</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>MR spectroscopy</topic><topic>N‐acetylaspartate</topic><topic>Pilocytic astrocytoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamrazi, Benita</creatorcontrib><creatorcontrib>Nelson, Marvin D.</creatorcontrib><creatorcontrib>Blüml, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamrazi, Benita</au><au>Nelson, Marvin D.</au><au>Blüml, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRS of pilocytic astrocytoma: The peak at 2 ppm may not be NAA</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn Reson Med</addtitle><date>2017-08</date><risdate>2017</risdate><volume>78</volume><issue>2</issue><spage>452</spage><epage>456</epage><pages>452-456</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>Purpose
To determine whether the chemical shift of residual N‐acetylaspartate (NAA) signal in pilocytic astrocytomas (PA) is consistent with the position of the NAA peak in controls.
Methods
MR spectra from 27 pediatric World Health Organization (WHO) grade I pilocytic astrocytoma patients, fifteen patients with WHO grade II and high‐grade (III–IV) astrocytomas, and 36 controls were analyzed. All spectra were acquired with a short echo time (35 ms), single voxel point‐resolved spectroscopy sequence on clinical 3 tesla scanners. Fully automated LCModel software was used for processing, which included the fitting of peak positions for NAA and creatine (Cr).
Results
The chemical shift difference between the NAA and Cr peaks was significantly smaller (by 0.016 ± 0.005 parts per million, P < 1e–10) in PAs than in controls and was also smaller than what was observed in infiltrative astrocytomas.
Conclusion
The chemical shift position of the residual NAA peak in PAs is not consistent with NAA. The signal likely originates from an N‐acetyl group of one or more other chemicals such as N‐acetylated sugars. Magn Reson Med 78:452–456, 2017. © 2016 International Society for Magnetic Resonance in Medicine</abstract><cop>United States</cop><pmid>27529659</pmid><doi>10.1002/mrm.26374</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Magnetic resonance in medicine, 2017-08, Vol.78 (2), p.452-456 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Aspartic Acid - analogs & derivatives Aspartic Acid - analysis Aspartic Acid - chemistry Aspartic Acid - metabolism Astrocytoma - diagnostic imaging Brain - diagnostic imaging Brain Neoplasms - diagnostic imaging Child Child, Preschool Humans Infant Magnetic Resonance Imaging - methods MR spectroscopy N‐acetylaspartate Pilocytic astrocytoma |
| title | MRS of pilocytic astrocytoma: The peak at 2 ppm may not be NAA |
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