Gene Polymorphisms for Both Auto-antigen and Immune-Modulating Proteins Are Associated with the Susceptibility of Autoimmune Myasthenia Gravis

Myasthenia gravis (MG) is an antibody-mediated autoimmune disease against antigens at the neuromuscular junction. Both genetic and environmental factors contribute to the susceptibility of MG. We undertook a case–control study to explore the contribution of genes of the auto-antigen and immune-modul...

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Veröffentlicht in:	Molecular neurobiology 2017-08, Vol.54 (6), p.4771-4780
Hauptverfasser:	Li, Hai-Feng, Hong, Yu, Zhang, Xu, Xie, Yanchen, Skeie, Geir Olve, Hao, Hong-Jun, Gilhus, Nils Erik, Liang, Bing, Yue, Yao-Xian, Zhang, Xian-Jun, Gao, Xiang, Wang, Qi, Gao, Zhe, Ding, Xiao-Jun, Song, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors Adolescent Adult Aged Aged, 80 and over AIRE protein Alleles Antibodies Antigens Autoantigens - genetics Autoimmune diseases Biomedical and Life Sciences Biomedicine Case-Control Studies Cell Biology CTLA-4 protein Cytotoxicity Environmental factors Epistasis, Genetic Female Gene Frequency - genetics Genes Genetic Association Studies Genetic Predisposition to Disease Humans Immunomodulation Interleukin 10 Linkage Disequilibrium - genetics Male Middle Aged Models, Genetic Myasthenia gravis Myasthenia Gravis - genetics Myasthenia Gravis - immunology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - immunology Neurobiology Neurology Neuromuscular junctions Neurosciences Pathogenesis Polymorphism Polymorphism, Single Nucleotide - genetics Protein-tyrosine-phosphatase Proteins Risk factors Single-nucleotide polymorphism Young Adult
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