Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment

Abstract Schizophrenia is a serious psychotic disorder, with disabling symptoms and markedly reduced life expectancy. The onset is usually in late adolescence or early adulthood, which in time overlaps with the maturation of the brain including the myelination process. Interestingly, there seems to...

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Veröffentlicht in:	European neuropsychopharmacology 2017-06, Vol.27 (6), p.589-598
Hauptverfasser:	Steen, Vidar M, Skrede, Silje, Polushina, Tatiana, López, Miguel, Andreassen, Ole A, Fernø, Johan, Hellard, Stephanie Le
Format:	Artikel
Sprache:	eng
Schlagworte:	Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Antipsychotics Cholesterol Humans Internal Medicine Lipogenesis - drug effects Lipogenesis - physiology Myelin Psychiatry Psychosis Schizophrenia - drug therapy Schizophrenia - genetics Schizophrenia - metabolism SREBF1 SREBF2 Sterol Regulatory Element Binding Protein 1 - physiology Sterol Regulatory Element Binding Protein 2 - physiology Transcription, Genetic - drug effects Transcription, Genetic - physiology
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