Successful treatment of radiation-induced mucositis with proton pump inhibitor administration: A report of two laryngeal cancer cases
Abstract Presently, the relationship between laryngopharyngeal reflux (LPR) and radiation-induced mucositis has not been fully explored. In the present study, we report 2 cases of laryngeal cancer in which radiation-induced mucositis ameliorated after proton pump inhibitor (PPI) administration. Case...
Gespeichert in:
| Veröffentlicht in: | Auris, nasus, larynx nasus, larynx, 2017-02, Vol.44 (1), p.122-125 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 125 |
|---|---|
| container_issue | 1 |
| container_start_page | 122 |
| container_title | Auris, nasus, larynx |
| container_volume | 44 |
| creator | Eguchi, Kohtaro Suzuki, Masami Ida, Shota Kudo, Shigehiro Ando, Ken Ebara, Takeshi Higuchi, Keiko |
| description | Abstract Presently, the relationship between laryngopharyngeal reflux (LPR) and radiation-induced mucositis has not been fully explored. In the present study, we report 2 cases of laryngeal cancer in which radiation-induced mucositis ameliorated after proton pump inhibitor (PPI) administration. Case 1 was diagnosed with T1aN0M0 right glottis carcinoma and was treated with radiation therapy. Grade 3 mucositis occurred after administration of 46 Gy irradiation. PPI was administered and mucositis ameliorated quickly without cessation of radiation therapy. Case 2 was diagnosed with T2N0M0 supraglottic cancer and was treated with concurrent chemoradiation therapy. Grade 3 mucositis occurred after administration of 44 Gy irradiation. PPI was administered and mucositis ameliorated quickly without cessation of chemoradiation therapy. In both cases, a remarkable therapeutic effect of PPI was observed in the perilaryngeal areas including the epiglottic vallecula, arytenoid, and postcricoid area. In both cases, LPR involvement was suspected before the onset of radiation therapy. The two cases presented here, indicated a causal relationship between LPR and radiation-induced mucositis. In cases of severe mucositis in the perilaryngeal area in patients with LPR prior to radiation therapy, PPI administration may be an effective therapeutic option. |
| doi_str_mv | 10.1016/j.anl.2016.05.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859709779</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0385814616301559</els_id><sourcerecordid>1859709779</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-aa21529a8f3d1001f83599485854fc97fb3e0893baa26b9ff28974d50499e15c3</originalsourceid><addsrcrecordid>eNp9kcFuFSEUhonR2NvqA7gxLN3MCMMwgCYmTaPVpImL6powzMFynYERGJs-gO8tt7e6cOHqsPj-P4fvIPSCkpYSOrzetybMbVefLeEtIcMjtKNSqIb2YniMdoRJ3kjaDyfoNOc9IYQJpp6ik050Qy9Fv0O_rjdrIWe3zbgkMGWBUHB0OJnJm-JjaHyYNgsTXjYbsy8-41tfbvCaYokBr9uyYh9u_OhLTNhMiw8-l3SffYPPcYI1pvvKchvxbNJd-AZmxtYEC6mODPkZeuLMnOH5wzxDXz-8_3Lxsbn6fPnp4vyqsT3rSmNMR3mnjHRsooRQJxlXqpdc8t5ZJdzIgEjFxgoOo3Kuk0r0Eye9UkC5ZWfo1bG3Lv9jg1z04rOFeTYB4pY1lVwJooRQFaVH1KaYcwKn1-SXur2mRB_s672u9vXBviZcV_s18_KhfhsXmP4m_uiuwNsjAPWTPz0kna2H6mHyCWzRU_T_rX_3T9rOVbY183e4g7yPWwrVnqY6d5ro68P5D9enAyOUc8V-A4OsrJY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859709779</pqid></control><display><type>article</type><title>Successful treatment of radiation-induced mucositis with proton pump inhibitor administration: A report of two laryngeal cancer cases</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Eguchi, Kohtaro ; Suzuki, Masami ; Ida, Shota ; Kudo, Shigehiro ; Ando, Ken ; Ebara, Takeshi ; Higuchi, Keiko</creator><creatorcontrib>Eguchi, Kohtaro ; Suzuki, Masami ; Ida, Shota ; Kudo, Shigehiro ; Ando, Ken ; Ebara, Takeshi ; Higuchi, Keiko</creatorcontrib><description>Abstract Presently, the relationship between laryngopharyngeal reflux (LPR) and radiation-induced mucositis has not been fully explored. In the present study, we report 2 cases of laryngeal cancer in which radiation-induced mucositis ameliorated after proton pump inhibitor (PPI) administration. Case 1 was diagnosed with T1aN0M0 right glottis carcinoma and was treated with radiation therapy. Grade 3 mucositis occurred after administration of 46 Gy irradiation. PPI was administered and mucositis ameliorated quickly without cessation of radiation therapy. Case 2 was diagnosed with T2N0M0 supraglottic cancer and was treated with concurrent chemoradiation therapy. Grade 3 mucositis occurred after administration of 44 Gy irradiation. PPI was administered and mucositis ameliorated quickly without cessation of chemoradiation therapy. In both cases, a remarkable therapeutic effect of PPI was observed in the perilaryngeal areas including the epiglottic vallecula, arytenoid, and postcricoid area. In both cases, LPR involvement was suspected before the onset of radiation therapy. The two cases presented here, indicated a causal relationship between LPR and radiation-induced mucositis. In cases of severe mucositis in the perilaryngeal area in patients with LPR prior to radiation therapy, PPI administration may be an effective therapeutic option.</description><identifier>ISSN: 0385-8146</identifier><identifier>EISSN: 1879-1476</identifier><identifier>DOI: 10.1016/j.anl.2016.05.006</identifier><identifier>PMID: 27264874</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Carcinoma - radiotherapy ; Glottis ; Head and neck cancer ; Humans ; Laryngeal Neoplasms - radiotherapy ; Laryngitis - drug therapy ; Laryngopharyngeal reflux ; Male ; Middle Aged ; Mucositis ; Mucositis - drug therapy ; Otolaryngology ; Proton pump inhibitor ; Proton Pump Inhibitors - therapeutic use ; Radiation ; Radiation Injuries - drug therapy</subject><ispartof>Auris, nasus, larynx, 2017-02, Vol.44 (1), p.122-125</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-aa21529a8f3d1001f83599485854fc97fb3e0893baa26b9ff28974d50499e15c3</citedby><cites>FETCH-LOGICAL-c432t-aa21529a8f3d1001f83599485854fc97fb3e0893baa26b9ff28974d50499e15c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0385814616301559$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27264874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eguchi, Kohtaro</creatorcontrib><creatorcontrib>Suzuki, Masami</creatorcontrib><creatorcontrib>Ida, Shota</creatorcontrib><creatorcontrib>Kudo, Shigehiro</creatorcontrib><creatorcontrib>Ando, Ken</creatorcontrib><creatorcontrib>Ebara, Takeshi</creatorcontrib><creatorcontrib>Higuchi, Keiko</creatorcontrib><title>Successful treatment of radiation-induced mucositis with proton pump inhibitor administration: A report of two laryngeal cancer cases</title><title>Auris, nasus, larynx</title><addtitle>Auris Nasus Larynx</addtitle><description>Abstract Presently, the relationship between laryngopharyngeal reflux (LPR) and radiation-induced mucositis has not been fully explored. In the present study, we report 2 cases of laryngeal cancer in which radiation-induced mucositis ameliorated after proton pump inhibitor (PPI) administration. Case 1 was diagnosed with T1aN0M0 right glottis carcinoma and was treated with radiation therapy. Grade 3 mucositis occurred after administration of 46 Gy irradiation. PPI was administered and mucositis ameliorated quickly without cessation of radiation therapy. Case 2 was diagnosed with T2N0M0 supraglottic cancer and was treated with concurrent chemoradiation therapy. Grade 3 mucositis occurred after administration of 44 Gy irradiation. PPI was administered and mucositis ameliorated quickly without cessation of chemoradiation therapy. In both cases, a remarkable therapeutic effect of PPI was observed in the perilaryngeal areas including the epiglottic vallecula, arytenoid, and postcricoid area. In both cases, LPR involvement was suspected before the onset of radiation therapy. The two cases presented here, indicated a causal relationship between LPR and radiation-induced mucositis. In cases of severe mucositis in the perilaryngeal area in patients with LPR prior to radiation therapy, PPI administration may be an effective therapeutic option.</description><subject>Aged</subject><subject>Carcinoma - radiotherapy</subject><subject>Glottis</subject><subject>Head and neck cancer</subject><subject>Humans</subject><subject>Laryngeal Neoplasms - radiotherapy</subject><subject>Laryngitis - drug therapy</subject><subject>Laryngopharyngeal reflux</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucositis</subject><subject>Mucositis - drug therapy</subject><subject>Otolaryngology</subject><subject>Proton pump inhibitor</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><subject>Radiation</subject><subject>Radiation Injuries - drug therapy</subject><issn>0385-8146</issn><issn>1879-1476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFuFSEUhonR2NvqA7gxLN3MCMMwgCYmTaPVpImL6powzMFynYERGJs-gO8tt7e6cOHqsPj-P4fvIPSCkpYSOrzetybMbVefLeEtIcMjtKNSqIb2YniMdoRJ3kjaDyfoNOc9IYQJpp6ik050Qy9Fv0O_rjdrIWe3zbgkMGWBUHB0OJnJm-JjaHyYNgsTXjYbsy8-41tfbvCaYokBr9uyYh9u_OhLTNhMiw8-l3SffYPPcYI1pvvKchvxbNJd-AZmxtYEC6mODPkZeuLMnOH5wzxDXz-8_3Lxsbn6fPnp4vyqsT3rSmNMR3mnjHRsooRQJxlXqpdc8t5ZJdzIgEjFxgoOo3Kuk0r0Eye9UkC5ZWfo1bG3Lv9jg1z04rOFeTYB4pY1lVwJooRQFaVH1KaYcwKn1-SXur2mRB_s672u9vXBviZcV_s18_KhfhsXmP4m_uiuwNsjAPWTPz0kna2H6mHyCWzRU_T_rX_3T9rOVbY183e4g7yPWwrVnqY6d5ro68P5D9enAyOUc8V-A4OsrJY</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Eguchi, Kohtaro</creator><creator>Suzuki, Masami</creator><creator>Ida, Shota</creator><creator>Kudo, Shigehiro</creator><creator>Ando, Ken</creator><creator>Ebara, Takeshi</creator><creator>Higuchi, Keiko</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>Successful treatment of radiation-induced mucositis with proton pump inhibitor administration: A report of two laryngeal cancer cases</title><author>Eguchi, Kohtaro ; Suzuki, Masami ; Ida, Shota ; Kudo, Shigehiro ; Ando, Ken ; Ebara, Takeshi ; Higuchi, Keiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-aa21529a8f3d1001f83599485854fc97fb3e0893baa26b9ff28974d50499e15c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Carcinoma - radiotherapy</topic><topic>Glottis</topic><topic>Head and neck cancer</topic><topic>Humans</topic><topic>Laryngeal Neoplasms - radiotherapy</topic><topic>Laryngitis - drug therapy</topic><topic>Laryngopharyngeal reflux</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucositis</topic><topic>Mucositis - drug therapy</topic><topic>Otolaryngology</topic><topic>Proton pump inhibitor</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><topic>Radiation</topic><topic>Radiation Injuries - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eguchi, Kohtaro</creatorcontrib><creatorcontrib>Suzuki, Masami</creatorcontrib><creatorcontrib>Ida, Shota</creatorcontrib><creatorcontrib>Kudo, Shigehiro</creatorcontrib><creatorcontrib>Ando, Ken</creatorcontrib><creatorcontrib>Ebara, Takeshi</creatorcontrib><creatorcontrib>Higuchi, Keiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Auris, nasus, larynx</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eguchi, Kohtaro</au><au>Suzuki, Masami</au><au>Ida, Shota</au><au>Kudo, Shigehiro</au><au>Ando, Ken</au><au>Ebara, Takeshi</au><au>Higuchi, Keiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of radiation-induced mucositis with proton pump inhibitor administration: A report of two laryngeal cancer cases</atitle><jtitle>Auris, nasus, larynx</jtitle><addtitle>Auris Nasus Larynx</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>44</volume><issue>1</issue><spage>122</spage><epage>125</epage><pages>122-125</pages><issn>0385-8146</issn><eissn>1879-1476</eissn><abstract>Abstract Presently, the relationship between laryngopharyngeal reflux (LPR) and radiation-induced mucositis has not been fully explored. In the present study, we report 2 cases of laryngeal cancer in which radiation-induced mucositis ameliorated after proton pump inhibitor (PPI) administration. Case 1 was diagnosed with T1aN0M0 right glottis carcinoma and was treated with radiation therapy. Grade 3 mucositis occurred after administration of 46 Gy irradiation. PPI was administered and mucositis ameliorated quickly without cessation of radiation therapy. Case 2 was diagnosed with T2N0M0 supraglottic cancer and was treated with concurrent chemoradiation therapy. Grade 3 mucositis occurred after administration of 44 Gy irradiation. PPI was administered and mucositis ameliorated quickly without cessation of chemoradiation therapy. In both cases, a remarkable therapeutic effect of PPI was observed in the perilaryngeal areas including the epiglottic vallecula, arytenoid, and postcricoid area. In both cases, LPR involvement was suspected before the onset of radiation therapy. The two cases presented here, indicated a causal relationship between LPR and radiation-induced mucositis. In cases of severe mucositis in the perilaryngeal area in patients with LPR prior to radiation therapy, PPI administration may be an effective therapeutic option.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27264874</pmid><doi>10.1016/j.anl.2016.05.006</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0385-8146 |
| ispartof | Auris, nasus, larynx, 2017-02, Vol.44 (1), p.122-125 |
| issn | 0385-8146 1879-1476 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1859709779 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Carcinoma - radiotherapy Glottis Head and neck cancer Humans Laryngeal Neoplasms - radiotherapy Laryngitis - drug therapy Laryngopharyngeal reflux Male Middle Aged Mucositis Mucositis - drug therapy Otolaryngology Proton pump inhibitor Proton Pump Inhibitors - therapeutic use Radiation Radiation Injuries - drug therapy |
| title | Successful treatment of radiation-induced mucositis with proton pump inhibitor administration: A report of two laryngeal cancer cases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T07%3A42%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Successful%20treatment%20of%20radiation-induced%20mucositis%20with%20proton%20pump%20inhibitor%20administration:%20A%20report%20of%20two%20laryngeal%20cancer%20cases&rft.jtitle=Auris,%20nasus,%20larynx&rft.au=Eguchi,%20Kohtaro&rft.date=2017-02-01&rft.volume=44&rft.issue=1&rft.spage=122&rft.epage=125&rft.pages=122-125&rft.issn=0385-8146&rft.eissn=1879-1476&rft_id=info:doi/10.1016/j.anl.2016.05.006&rft_dat=%3Cproquest_cross%3E1859709779%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1859709779&rft_id=info:pmid/27264874&rft_els_id=1_s2_0_S0385814616301559&rfr_iscdi=true |