Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A sub(2) (Lp-PLA sub(2)) Inhibitor [ super(18)F]GSK2647544 in Healthy Male Subjects

GSK2647544 is a potent and specific inhibitor of lipoprotein-associated phospholipase A sub(2) (Lp-PLA sub(2)), which was in development as a potential treatment for Alzheimer's disease (AD). In order to refine therapeutic dose predictions and confirm brain penetration, a radiolabelled form of...

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Veröffentlicht in:	Molecular imaging and biology 2017-02, Vol.19 (1), p.153-161
Hauptverfasser:	Huiban, Mickael, Coello, Christopher, Wu, Kai, Xu, Yanmei, Lewis, Yvonne, Brown, Andrew P, Buraglio, Mauro, Guan, Chenbing, Shabbir, Shaila, Fong, Regan, Passchier, Jan, Rabiner, Eugenii A, Lockhart, Andrew
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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