A phase III observer-blind randomized, controlled study to evaluate the immune response and the correlation with nasopharyngeal carriage after immunization of university students with a quadrivalent meningococcal ACWY glycoconjugate or serogroup B meningococcal vaccine
Abstract Background University students have high rates of pharyngeal carriage of Neisseria meningitidis . Interruption of carriage acquisition is an important mechanism of vaccines for inducing herd protection. 4CMenB and MenACWY-CRM vaccines have been shown to be immunogenic against meningococcal...
Gespeichert in:
| Veröffentlicht in: | Vaccine 2017-01, Vol.35 (3), p.427-434 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 434 |
|---|---|
| container_issue | 3 |
| container_start_page | 427 |
| container_title | Vaccine |
| container_volume | 35 |
| creator | Read, Robert C Dull, Peter Bai, Xilian Nolan, Kate Findlow, Jamie Bazaz, Rohit Kleinschmidt, Annett McCarthy, Maggie Wang, Huajun Toneatto, Daniela Borrow, Ray |
| description | Abstract Background University students have high rates of pharyngeal carriage of Neisseria meningitidis . Interruption of carriage acquisition is an important mechanism of vaccines for inducing herd protection. 4CMenB and MenACWY-CRM vaccines have been shown to be immunogenic against meningococcal serogroups B and ACWY respectively in younger age groups, and also to elicit a modest impact on meningococcal carriage in vaccinated students. However, vaccine responses in university students and the impact of serum bactericidal antibody (SBA) titers on meningococcal carriage are undetermined. Methods Immunogenicity of two 4CMenB doses or one MenACWY-CRM dose was measured in university students at Months 2, 4, 6 and 12 post-first vaccination. Immunogenicity of one MenACWY-CRM dose in students with previous meningococcal serogroup C conjugate vaccination was also assessed. Immune responses were measured with an SBA assay using human complement (hSBA) against three reference strains for serogroup B and against one strain for each for serogroups C and Y. Correlations between hSBA titers and meningococcal carriage were analyzed. Results All subjects demonstrated robust functional antibody responses to both vaccines at Month 2 and a high proportion maintained protective hSBA titers up to Month 12. At baseline, carriage of disease-associated serogroup B strains and serogroups C and Y were higher in subjects with already-protective hSBA titers. Post-vaccination, while both 4CMenB and MenACWY-CRM elicited robust immunogenicity in students, significant correlations between post-vaccination hSBA titers and carriage of disease-associated serogroups were not observed. Conclusions 4CMenB and MenACWY-CRM were both highly immunogenic. There was no correlation between carriage and post-vaccination hSBA titers. |
| doi_str_mv | 10.1016/j.vaccine.2016.11.071 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859499860</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0264410X16311422</els_id><sourcerecordid>4287303201</sourcerecordid><originalsourceid>FETCH-LOGICAL-c528t-c72152f09e904af32bea82984940454d9c8a78983cd4ae49cfe0c2eeb048831c3</originalsourceid><addsrcrecordid>eNqNUk2P0zAQDQjElmV_AsgSFw6k2I7TJJdFpeKj0kocAAEny3UmWZfE7tpOUffXM9kUkHqBkzXWe2_ezLwkecronFG2eLWd75XWxsKcYzlnbE4Ldj-ZsbLIUp6z8kEyo3whUsHot7PkcQhbSmmesepRcsaLivGqXMzuXSzJ7loFIOv1mrhNAL8Hn246Y2vila1db26hfkm0s9G7roOahDjUBxIdgb3qBhWBxGsgpu8HC8RD2DmLesi9-9fOe-hUNM6SnyZeE6uCw5b-YFtQHdHKe6NaJDQR_CRjbie8awgWaCiYeLjrCzaGSUaRm0HV3qAH_CQ9WGNbp53WKLpcff1O2u6ApbPboR1NOk9wOtd6N-zImxPCcZdPkoeN6gJcHN_z5Mu7t59XH9Krj-_Xq-VVqnNexlQXnOW8oRVUVKgm4xtQJe5TVIKKXNSVLlVRVmWma6FAVLoBqjnAhoqyzJjOzpMXk-7Ou5sBQpS9CRq6TllwQ5CszCtR4YHof0BFXmYLKiqEPj-Bbt3gLQ4yCqK_PBcFovIJpb0LwUMjd970eA_JqByjJbfyuA45RksyJjFayHt2VB82PdR_WL-zhIDXEwBwc3sDXgZtwGqojQcdZe3MP1tcnihoDKLBA_2AA4S_08jAJZWfxnyP8WaLjDHBefYLjBz-Kw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1852985547</pqid></control><display><type>article</type><title>A phase III observer-blind randomized, controlled study to evaluate the immune response and the correlation with nasopharyngeal carriage after immunization of university students with a quadrivalent meningococcal ACWY glycoconjugate or serogroup B meningococcal vaccine</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>ProQuest Central UK/Ireland</source><creator>Read, Robert C ; Dull, Peter ; Bai, Xilian ; Nolan, Kate ; Findlow, Jamie ; Bazaz, Rohit ; Kleinschmidt, Annett ; McCarthy, Maggie ; Wang, Huajun ; Toneatto, Daniela ; Borrow, Ray</creator><creatorcontrib>Read, Robert C ; Dull, Peter ; Bai, Xilian ; Nolan, Kate ; Findlow, Jamie ; Bazaz, Rohit ; Kleinschmidt, Annett ; McCarthy, Maggie ; Wang, Huajun ; Toneatto, Daniela ; Borrow, Ray</creatorcontrib><description>Abstract Background University students have high rates of pharyngeal carriage of Neisseria meningitidis . Interruption of carriage acquisition is an important mechanism of vaccines for inducing herd protection. 4CMenB and MenACWY-CRM vaccines have been shown to be immunogenic against meningococcal serogroups B and ACWY respectively in younger age groups, and also to elicit a modest impact on meningococcal carriage in vaccinated students. However, vaccine responses in university students and the impact of serum bactericidal antibody (SBA) titers on meningococcal carriage are undetermined. Methods Immunogenicity of two 4CMenB doses or one MenACWY-CRM dose was measured in university students at Months 2, 4, 6 and 12 post-first vaccination. Immunogenicity of one MenACWY-CRM dose in students with previous meningococcal serogroup C conjugate vaccination was also assessed. Immune responses were measured with an SBA assay using human complement (hSBA) against three reference strains for serogroup B and against one strain for each for serogroups C and Y. Correlations between hSBA titers and meningococcal carriage were analyzed. Results All subjects demonstrated robust functional antibody responses to both vaccines at Month 2 and a high proportion maintained protective hSBA titers up to Month 12. At baseline, carriage of disease-associated serogroup B strains and serogroups C and Y were higher in subjects with already-protective hSBA titers. Post-vaccination, while both 4CMenB and MenACWY-CRM elicited robust immunogenicity in students, significant correlations between post-vaccination hSBA titers and carriage of disease-associated serogroups were not observed. Conclusions 4CMenB and MenACWY-CRM were both highly immunogenic. There was no correlation between carriage and post-vaccination hSBA titers.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2016.11.071</identifier><identifier>PMID: 27912986</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Allergy and Immunology ; Antibodies, Bacterial - blood ; Blood Bactericidal Activity ; Carriage ; Carrier State - microbiology ; Carrier State - prevention & control ; Female ; Humans ; Immune response ; Immunization ; Immunogenicity ; Male ; Meningococcal ; Meningococcal Infections - microbiology ; Meningococcal Infections - prevention & control ; Meningococcal Vaccines - administration & dosage ; Meningococcal Vaccines - immunology ; Nasopharynx - microbiology ; Neisseria meningitidis ; Neisseria meningitidis - classification ; Neisseria meningitidis - isolation & purification ; Proteins ; Serogroup B ; Single-Blind Method ; Students ; Universities ; Vaccine ; Vaccines ; Young Adult</subject><ispartof>Vaccine, 2017-01, Vol.35 (3), p.427-434</ispartof><rights>2016</rights><rights>Copyright © 2016. Published by Elsevier Ltd.</rights><rights>Copyright Elsevier Limited Jan 11, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-c72152f09e904af32bea82984940454d9c8a78983cd4ae49cfe0c2eeb048831c3</citedby><cites>FETCH-LOGICAL-c528t-c72152f09e904af32bea82984940454d9c8a78983cd4ae49cfe0c2eeb048831c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1852985547?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27912986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Read, Robert C</creatorcontrib><creatorcontrib>Dull, Peter</creatorcontrib><creatorcontrib>Bai, Xilian</creatorcontrib><creatorcontrib>Nolan, Kate</creatorcontrib><creatorcontrib>Findlow, Jamie</creatorcontrib><creatorcontrib>Bazaz, Rohit</creatorcontrib><creatorcontrib>Kleinschmidt, Annett</creatorcontrib><creatorcontrib>McCarthy, Maggie</creatorcontrib><creatorcontrib>Wang, Huajun</creatorcontrib><creatorcontrib>Toneatto, Daniela</creatorcontrib><creatorcontrib>Borrow, Ray</creatorcontrib><title>A phase III observer-blind randomized, controlled study to evaluate the immune response and the correlation with nasopharyngeal carriage after immunization of university students with a quadrivalent meningococcal ACWY glycoconjugate or serogroup B meningococcal vaccine</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Background University students have high rates of pharyngeal carriage of Neisseria meningitidis . Interruption of carriage acquisition is an important mechanism of vaccines for inducing herd protection. 4CMenB and MenACWY-CRM vaccines have been shown to be immunogenic against meningococcal serogroups B and ACWY respectively in younger age groups, and also to elicit a modest impact on meningococcal carriage in vaccinated students. However, vaccine responses in university students and the impact of serum bactericidal antibody (SBA) titers on meningococcal carriage are undetermined. Methods Immunogenicity of two 4CMenB doses or one MenACWY-CRM dose was measured in university students at Months 2, 4, 6 and 12 post-first vaccination. Immunogenicity of one MenACWY-CRM dose in students with previous meningococcal serogroup C conjugate vaccination was also assessed. Immune responses were measured with an SBA assay using human complement (hSBA) against three reference strains for serogroup B and against one strain for each for serogroups C and Y. Correlations between hSBA titers and meningococcal carriage were analyzed. Results All subjects demonstrated robust functional antibody responses to both vaccines at Month 2 and a high proportion maintained protective hSBA titers up to Month 12. At baseline, carriage of disease-associated serogroup B strains and serogroups C and Y were higher in subjects with already-protective hSBA titers. Post-vaccination, while both 4CMenB and MenACWY-CRM elicited robust immunogenicity in students, significant correlations between post-vaccination hSBA titers and carriage of disease-associated serogroups were not observed. Conclusions 4CMenB and MenACWY-CRM were both highly immunogenic. There was no correlation between carriage and post-vaccination hSBA titers.</description><subject>Adolescent</subject><subject>Allergy and Immunology</subject><subject>Antibodies, Bacterial - blood</subject><subject>Blood Bactericidal Activity</subject><subject>Carriage</subject><subject>Carrier State - microbiology</subject><subject>Carrier State - prevention & control</subject><subject>Female</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunization</subject><subject>Immunogenicity</subject><subject>Male</subject><subject>Meningococcal</subject><subject>Meningococcal Infections - microbiology</subject><subject>Meningococcal Infections - prevention & control</subject><subject>Meningococcal Vaccines - administration & dosage</subject><subject>Meningococcal Vaccines - immunology</subject><subject>Nasopharynx - microbiology</subject><subject>Neisseria meningitidis</subject><subject>Neisseria meningitidis - classification</subject><subject>Neisseria meningitidis - isolation & purification</subject><subject>Proteins</subject><subject>Serogroup B</subject><subject>Single-Blind Method</subject><subject>Students</subject><subject>Universities</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>Young Adult</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNUk2P0zAQDQjElmV_AsgSFw6k2I7TJJdFpeKj0kocAAEny3UmWZfE7tpOUffXM9kUkHqBkzXWe2_ezLwkecronFG2eLWd75XWxsKcYzlnbE4Ldj-ZsbLIUp6z8kEyo3whUsHot7PkcQhbSmmesepRcsaLivGqXMzuXSzJ7loFIOv1mrhNAL8Hn246Y2vila1db26hfkm0s9G7roOahDjUBxIdgb3qBhWBxGsgpu8HC8RD2DmLesi9-9fOe-hUNM6SnyZeE6uCw5b-YFtQHdHKe6NaJDQR_CRjbie8awgWaCiYeLjrCzaGSUaRm0HV3qAH_CQ9WGNbp53WKLpcff1O2u6ApbPboR1NOk9wOtd6N-zImxPCcZdPkoeN6gJcHN_z5Mu7t59XH9Krj-_Xq-VVqnNexlQXnOW8oRVUVKgm4xtQJe5TVIKKXNSVLlVRVmWma6FAVLoBqjnAhoqyzJjOzpMXk-7Ou5sBQpS9CRq6TllwQ5CszCtR4YHof0BFXmYLKiqEPj-Bbt3gLQ4yCqK_PBcFovIJpb0LwUMjd970eA_JqByjJbfyuA45RksyJjFayHt2VB82PdR_WL-zhIDXEwBwc3sDXgZtwGqojQcdZe3MP1tcnihoDKLBA_2AA4S_08jAJZWfxnyP8WaLjDHBefYLjBz-Kw</recordid><startdate>20170111</startdate><enddate>20170111</enddate><creator>Read, Robert C</creator><creator>Dull, Peter</creator><creator>Bai, Xilian</creator><creator>Nolan, Kate</creator><creator>Findlow, Jamie</creator><creator>Bazaz, Rohit</creator><creator>Kleinschmidt, Annett</creator><creator>McCarthy, Maggie</creator><creator>Wang, Huajun</creator><creator>Toneatto, Daniela</creator><creator>Borrow, Ray</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U2</scope></search><sort><creationdate>20170111</creationdate><title>A phase III observer-blind randomized, controlled study to evaluate the immune response and the correlation with nasopharyngeal carriage after immunization of university students with a quadrivalent meningococcal ACWY glycoconjugate or serogroup B meningococcal vaccine</title><author>Read, Robert C ; Dull, Peter ; Bai, Xilian ; Nolan, Kate ; Findlow, Jamie ; Bazaz, Rohit ; Kleinschmidt, Annett ; McCarthy, Maggie ; Wang, Huajun ; Toneatto, Daniela ; Borrow, Ray</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-c72152f09e904af32bea82984940454d9c8a78983cd4ae49cfe0c2eeb048831c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Allergy and Immunology</topic><topic>Antibodies, Bacterial - blood</topic><topic>Blood Bactericidal Activity</topic><topic>Carriage</topic><topic>Carrier State - microbiology</topic><topic>Carrier State - prevention & control</topic><topic>Female</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunization</topic><topic>Immunogenicity</topic><topic>Male</topic><topic>Meningococcal</topic><topic>Meningococcal Infections - microbiology</topic><topic>Meningococcal Infections - prevention & control</topic><topic>Meningococcal Vaccines - administration & dosage</topic><topic>Meningococcal Vaccines - immunology</topic><topic>Nasopharynx - microbiology</topic><topic>Neisseria meningitidis</topic><topic>Neisseria meningitidis - classification</topic><topic>Neisseria meningitidis - isolation & purification</topic><topic>Proteins</topic><topic>Serogroup B</topic><topic>Single-Blind Method</topic><topic>Students</topic><topic>Universities</topic><topic>Vaccine</topic><topic>Vaccines</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Read, Robert C</creatorcontrib><creatorcontrib>Dull, Peter</creatorcontrib><creatorcontrib>Bai, Xilian</creatorcontrib><creatorcontrib>Nolan, Kate</creatorcontrib><creatorcontrib>Findlow, Jamie</creatorcontrib><creatorcontrib>Bazaz, Rohit</creatorcontrib><creatorcontrib>Kleinschmidt, Annett</creatorcontrib><creatorcontrib>McCarthy, Maggie</creatorcontrib><creatorcontrib>Wang, Huajun</creatorcontrib><creatorcontrib>Toneatto, Daniela</creatorcontrib><creatorcontrib>Borrow, Ray</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Read, Robert C</au><au>Dull, Peter</au><au>Bai, Xilian</au><au>Nolan, Kate</au><au>Findlow, Jamie</au><au>Bazaz, Rohit</au><au>Kleinschmidt, Annett</au><au>McCarthy, Maggie</au><au>Wang, Huajun</au><au>Toneatto, Daniela</au><au>Borrow, Ray</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A phase III observer-blind randomized, controlled study to evaluate the immune response and the correlation with nasopharyngeal carriage after immunization of university students with a quadrivalent meningococcal ACWY glycoconjugate or serogroup B meningococcal vaccine</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2017-01-11</date><risdate>2017</risdate><volume>35</volume><issue>3</issue><spage>427</spage><epage>434</epage><pages>427-434</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Abstract Background University students have high rates of pharyngeal carriage of Neisseria meningitidis . Interruption of carriage acquisition is an important mechanism of vaccines for inducing herd protection. 4CMenB and MenACWY-CRM vaccines have been shown to be immunogenic against meningococcal serogroups B and ACWY respectively in younger age groups, and also to elicit a modest impact on meningococcal carriage in vaccinated students. However, vaccine responses in university students and the impact of serum bactericidal antibody (SBA) titers on meningococcal carriage are undetermined. Methods Immunogenicity of two 4CMenB doses or one MenACWY-CRM dose was measured in university students at Months 2, 4, 6 and 12 post-first vaccination. Immunogenicity of one MenACWY-CRM dose in students with previous meningococcal serogroup C conjugate vaccination was also assessed. Immune responses were measured with an SBA assay using human complement (hSBA) against three reference strains for serogroup B and against one strain for each for serogroups C and Y. Correlations between hSBA titers and meningococcal carriage were analyzed. Results All subjects demonstrated robust functional antibody responses to both vaccines at Month 2 and a high proportion maintained protective hSBA titers up to Month 12. At baseline, carriage of disease-associated serogroup B strains and serogroups C and Y were higher in subjects with already-protective hSBA titers. Post-vaccination, while both 4CMenB and MenACWY-CRM elicited robust immunogenicity in students, significant correlations between post-vaccination hSBA titers and carriage of disease-associated serogroups were not observed. Conclusions 4CMenB and MenACWY-CRM were both highly immunogenic. There was no correlation between carriage and post-vaccination hSBA titers.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>27912986</pmid><doi>10.1016/j.vaccine.2016.11.071</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2017-01, Vol.35 (3), p.427-434 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1859499860 |
| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Adolescent Allergy and Immunology Antibodies, Bacterial - blood Blood Bactericidal Activity Carriage Carrier State - microbiology Carrier State - prevention & control Female Humans Immune response Immunization Immunogenicity Male Meningococcal Meningococcal Infections - microbiology Meningococcal Infections - prevention & control Meningococcal Vaccines - administration & dosage Meningococcal Vaccines - immunology Nasopharynx - microbiology Neisseria meningitidis Neisseria meningitidis - classification Neisseria meningitidis - isolation & purification Proteins Serogroup B Single-Blind Method Students Universities Vaccine Vaccines Young Adult |
| title | A phase III observer-blind randomized, controlled study to evaluate the immune response and the correlation with nasopharyngeal carriage after immunization of university students with a quadrivalent meningococcal ACWY glycoconjugate or serogroup B meningococcal vaccine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T17%3A55%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20phase%20III%20observer-blind%20randomized,%20controlled%20study%20to%20evaluate%20the%20immune%20response%20and%20the%20correlation%20with%20nasopharyngeal%20carriage%20after%20immunization%20of%20university%20students%20with%20a%20quadrivalent%20meningococcal%20ACWY%20glycoconjugate%20or%20serogroup%20B%20meningococcal%20vaccine&rft.jtitle=Vaccine&rft.au=Read,%20Robert%20C&rft.date=2017-01-11&rft.volume=35&rft.issue=3&rft.spage=427&rft.epage=434&rft.pages=427-434&rft.issn=0264-410X&rft.eissn=1873-2518&rft_id=info:doi/10.1016/j.vaccine.2016.11.071&rft_dat=%3Cproquest_cross%3E4287303201%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1852985547&rft_id=info:pmid/27912986&rft_els_id=S0264410X16311422&rfr_iscdi=true |