Switching of adenosine diphosphate receptor inhibitor after hospital discharge among myocardial infarction patients: Insights from the Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) observational study
The reasons for postdischarge adenosine diphosphate receptor inhibitor (ADPri) switching among patients with myocardial infarction (MI) are unclear. We sought to describe the incidence and patterns of postdischarge ADPri switching among patients with acute MI treated with percutaneous coronary inter...
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Veröffentlicht in: | The American heart journal 2017-01, Vol.183, p.62-68 |
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creator | Zettler, Marjorie E. Peterson, Eric D. McCoy, Lisa A. Effron, Mark B. Anstrom, Kevin J. Henry, Timothy D. Baker, Brian A. Messenger, John C. Cohen, David J. Wang, Tracy Y. |
description | The reasons for postdischarge adenosine diphosphate receptor inhibitor (ADPri) switching among patients with myocardial infarction (MI) are unclear. We sought to describe the incidence and patterns of postdischarge ADPri switching among patients with acute MI treated with percutaneous coronary intervention.
We used TRANSLATE-ACS (2010-2012) data to assess postdischarge ADPri switching among 8,672 MI patients discharged after percutaneous coronary intervention who remained on ADPri therapy 1 year post-MI. We examined patient-reported reasons for switching, GUSTO moderate or severe bleeding, major adverse cardiovascular events (MACEs), and definite stent thrombosis events around the time of the switch.
Among patients still on ADPri therapy 1 year post-MI, 663 (7.6%) switched ADPri during that year. Switching occurred at a median of 50 days postdischarge and most frequently in patients discharged on ticagrelor (64/226; 28.3%), followed by prasugrel (383/2,489; 15.4%) and clopidogrel (216/5,957; 3.6%) (P < .001). Among patients discharged on prasugrel, 97.3% of switches were to clopidogrel and 87.5% of ticagrelor switches were to clopidogrel; both of these groups most often cited cost as a reason for switching (43.6% and 39.1%, respectively), whereas 60.7% who switched from clopidogrel cited physician decision as a reason. In the 7 days preceding the switch from clopidogrel, 40 (18.5%) had a MACE and 12 (5.6%) had a definite stent thrombosis event, whereas that from prasugrel or ticagrelor, a GUSTO moderate or severe bleeding event occurred in 1 (0.3%) and 0 patients, respectively.
Postdischarge ADPri switching occurred infrequently within the first year post-MI and uncommonly was associated with MACEs or bleeding events. |
doi_str_mv | 10.1016/j.ahj.2016.10.006 |
format | Article |
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We used TRANSLATE-ACS (2010-2012) data to assess postdischarge ADPri switching among 8,672 MI patients discharged after percutaneous coronary intervention who remained on ADPri therapy 1 year post-MI. We examined patient-reported reasons for switching, GUSTO moderate or severe bleeding, major adverse cardiovascular events (MACEs), and definite stent thrombosis events around the time of the switch.
Among patients still on ADPri therapy 1 year post-MI, 663 (7.6%) switched ADPri during that year. Switching occurred at a median of 50 days postdischarge and most frequently in patients discharged on ticagrelor (64/226; 28.3%), followed by prasugrel (383/2,489; 15.4%) and clopidogrel (216/5,957; 3.6%) (P < .001). Among patients discharged on prasugrel, 97.3% of switches were to clopidogrel and 87.5% of ticagrelor switches were to clopidogrel; both of these groups most often cited cost as a reason for switching (43.6% and 39.1%, respectively), whereas 60.7% who switched from clopidogrel cited physician decision as a reason. In the 7 days preceding the switch from clopidogrel, 40 (18.5%) had a MACE and 12 (5.6%) had a definite stent thrombosis event, whereas that from prasugrel or ticagrelor, a GUSTO moderate or severe bleeding event occurred in 1 (0.3%) and 0 patients, respectively.
Postdischarge ADPri switching occurred infrequently within the first year post-MI and uncommonly was associated with MACEs or bleeding events.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2016.10.006</identifier><identifier>PMID: 27979043</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute coronary syndromes ; Adenosine - analogs & derivatives ; Adenosine - therapeutic use ; Adenosine Diphosphate ; Aged ; Cardiovascular Diseases - epidemiology ; Coronary vessels ; Data collection ; Drug Substitution - statistics & numerical data ; Family medical history ; Female ; Heart attacks ; Hemorrhage - chemically induced ; Humans ; Longitudinal Studies ; Male ; Medical records ; Middle Aged ; Mortality ; Myocardial Infarction - drug therapy ; Patient Discharge ; Patient Preference ; Patients ; Platelet Aggregation Inhibitors - therapeutic use ; Prasugrel Hydrochloride - therapeutic use ; Purinergic P1 Receptor Antagonists - adverse effects ; Purinergic P1 Receptor Antagonists - economics ; Purinergic P1 Receptor Antagonists - therapeutic use ; Thrombosis ; Ticlopidine - analogs & derivatives ; Ticlopidine - therapeutic use ; Variables ; Veins & arteries</subject><ispartof>The American heart journal, 2017-01, Vol.183, p.62-68</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jan 01, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-8032d5d783f02fdb6adfe13cde97f04eebe1489567214af723ea5b72678f57583</citedby><cites>FETCH-LOGICAL-c414t-8032d5d783f02fdb6adfe13cde97f04eebe1489567214af723ea5b72678f57583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1848800271?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72341</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27979043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zettler, Marjorie E.</creatorcontrib><creatorcontrib>Peterson, Eric D.</creatorcontrib><creatorcontrib>McCoy, Lisa A.</creatorcontrib><creatorcontrib>Effron, Mark B.</creatorcontrib><creatorcontrib>Anstrom, Kevin J.</creatorcontrib><creatorcontrib>Henry, Timothy D.</creatorcontrib><creatorcontrib>Baker, Brian A.</creatorcontrib><creatorcontrib>Messenger, John C.</creatorcontrib><creatorcontrib>Cohen, David J.</creatorcontrib><creatorcontrib>Wang, Tracy Y.</creatorcontrib><creatorcontrib>on behalf of the TRANSLATE-ACS Investigators</creatorcontrib><creatorcontrib>TRANSLATE-ACS Investigators</creatorcontrib><title>Switching of adenosine diphosphate receptor inhibitor after hospital discharge among myocardial infarction patients: Insights from the Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) observational study</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>The reasons for postdischarge adenosine diphosphate receptor inhibitor (ADPri) switching among patients with myocardial infarction (MI) are unclear. We sought to describe the incidence and patterns of postdischarge ADPri switching among patients with acute MI treated with percutaneous coronary intervention.
We used TRANSLATE-ACS (2010-2012) data to assess postdischarge ADPri switching among 8,672 MI patients discharged after percutaneous coronary intervention who remained on ADPri therapy 1 year post-MI. We examined patient-reported reasons for switching, GUSTO moderate or severe bleeding, major adverse cardiovascular events (MACEs), and definite stent thrombosis events around the time of the switch.
Among patients still on ADPri therapy 1 year post-MI, 663 (7.6%) switched ADPri during that year. Switching occurred at a median of 50 days postdischarge and most frequently in patients discharged on ticagrelor (64/226; 28.3%), followed by prasugrel (383/2,489; 15.4%) and clopidogrel (216/5,957; 3.6%) (P < .001). Among patients discharged on prasugrel, 97.3% of switches were to clopidogrel and 87.5% of ticagrelor switches were to clopidogrel; both of these groups most often cited cost as a reason for switching (43.6% and 39.1%, respectively), whereas 60.7% who switched from clopidogrel cited physician decision as a reason. In the 7 days preceding the switch from clopidogrel, 40 (18.5%) had a MACE and 12 (5.6%) had a definite stent thrombosis event, whereas that from prasugrel or ticagrelor, a GUSTO moderate or severe bleeding event occurred in 1 (0.3%) and 0 patients, respectively.
Postdischarge ADPri switching occurred infrequently within the first year post-MI and uncommonly was associated with MACEs or bleeding events.</description><subject>Acute coronary syndromes</subject><subject>Adenosine - analogs & derivatives</subject><subject>Adenosine - therapeutic use</subject><subject>Adenosine Diphosphate</subject><subject>Aged</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Coronary vessels</subject><subject>Data collection</subject><subject>Drug Substitution - statistics & numerical data</subject><subject>Family medical history</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Hemorrhage - chemically induced</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical records</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Patient Discharge</subject><subject>Patient Preference</subject><subject>Patients</subject><subject>Platelet Aggregation Inhibitors - 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analogs & derivatives</topic><topic>Adenosine - therapeutic use</topic><topic>Adenosine Diphosphate</topic><topic>Aged</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Coronary vessels</topic><topic>Data collection</topic><topic>Drug Substitution - statistics & numerical data</topic><topic>Family medical history</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Hemorrhage - chemically induced</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical records</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Patient Discharge</topic><topic>Patient Preference</topic><topic>Patients</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Prasugrel Hydrochloride - therapeutic use</topic><topic>Purinergic P1 Receptor Antagonists - adverse effects</topic><topic>Purinergic P1 Receptor Antagonists - economics</topic><topic>Purinergic P1 Receptor Antagonists - 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Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zettler, Marjorie E.</au><au>Peterson, Eric D.</au><au>McCoy, Lisa A.</au><au>Effron, Mark B.</au><au>Anstrom, Kevin J.</au><au>Henry, Timothy D.</au><au>Baker, Brian A.</au><au>Messenger, John C.</au><au>Cohen, David J.</au><au>Wang, Tracy Y.</au><aucorp>on behalf of the TRANSLATE-ACS Investigators</aucorp><aucorp>TRANSLATE-ACS Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Switching of adenosine diphosphate receptor inhibitor after hospital discharge among myocardial infarction patients: Insights from the Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) observational study</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2017-01</date><risdate>2017</risdate><volume>183</volume><spage>62</spage><epage>68</epage><pages>62-68</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>The reasons for postdischarge adenosine diphosphate receptor inhibitor (ADPri) switching among patients with myocardial infarction (MI) are unclear. We sought to describe the incidence and patterns of postdischarge ADPri switching among patients with acute MI treated with percutaneous coronary intervention.
We used TRANSLATE-ACS (2010-2012) data to assess postdischarge ADPri switching among 8,672 MI patients discharged after percutaneous coronary intervention who remained on ADPri therapy 1 year post-MI. We examined patient-reported reasons for switching, GUSTO moderate or severe bleeding, major adverse cardiovascular events (MACEs), and definite stent thrombosis events around the time of the switch.
Among patients still on ADPri therapy 1 year post-MI, 663 (7.6%) switched ADPri during that year. Switching occurred at a median of 50 days postdischarge and most frequently in patients discharged on ticagrelor (64/226; 28.3%), followed by prasugrel (383/2,489; 15.4%) and clopidogrel (216/5,957; 3.6%) (P < .001). Among patients discharged on prasugrel, 97.3% of switches were to clopidogrel and 87.5% of ticagrelor switches were to clopidogrel; both of these groups most often cited cost as a reason for switching (43.6% and 39.1%, respectively), whereas 60.7% who switched from clopidogrel cited physician decision as a reason. In the 7 days preceding the switch from clopidogrel, 40 (18.5%) had a MACE and 12 (5.6%) had a definite stent thrombosis event, whereas that from prasugrel or ticagrelor, a GUSTO moderate or severe bleeding event occurred in 1 (0.3%) and 0 patients, respectively.
Postdischarge ADPri switching occurred infrequently within the first year post-MI and uncommonly was associated with MACEs or bleeding events.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27979043</pmid><doi>10.1016/j.ahj.2016.10.006</doi><tpages>7</tpages></addata></record> |
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source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
subjects | Acute coronary syndromes Adenosine - analogs & derivatives Adenosine - therapeutic use Adenosine Diphosphate Aged Cardiovascular Diseases - epidemiology Coronary vessels Data collection Drug Substitution - statistics & numerical data Family medical history Female Heart attacks Hemorrhage - chemically induced Humans Longitudinal Studies Male Medical records Middle Aged Mortality Myocardial Infarction - drug therapy Patient Discharge Patient Preference Patients Platelet Aggregation Inhibitors - therapeutic use Prasugrel Hydrochloride - therapeutic use Purinergic P1 Receptor Antagonists - adverse effects Purinergic P1 Receptor Antagonists - economics Purinergic P1 Receptor Antagonists - therapeutic use Thrombosis Ticlopidine - analogs & derivatives Ticlopidine - therapeutic use Variables Veins & arteries |
title | Switching of adenosine diphosphate receptor inhibitor after hospital discharge among myocardial infarction patients: Insights from the Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) observational study |
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