Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India
Human reproduction is considered as the most inefficient event as ∼15–20% of human pregnancies end in miscarriage and in the product of miscarriages, chromosomal anomalies are a common occurrence. The aim of the present retrospective study was to assess the frequency of chromosomal aberrations in co...
Gespeichert in:
| Veröffentlicht in: | Journal of genetics 2016-12, Vol.95 (4), p.887-894 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 894 |
|---|---|
| container_issue | 4 |
| container_start_page | 887 |
| container_title | Journal of genetics |
| container_volume | 95 |
| creator | SUDHIR, NEHA KAUR, TAJINDER BERI, ARCHANA KAUR, ANUPAM |
| description | Human reproduction is considered as the most inefficient event as ∼15–20% of human pregnancies end in miscarriage and in the product of miscarriages, chromosomal anomalies are a common occurrence. The aim of the present retrospective study was to assess the frequency of chromosomal aberrations in couples with recurrent miscarriages in the region of Punjab and to compare with worldwide frequencies. In this study, a total of 440 cases were referred between the period 1995–2015. After lymphocyte culturing, giemsa–trypsin banding was done for each case to assess the chromosomal anomalies. The frequency of chromosomal aberrations among couples was found to be 3.41% in our study. Among these aberrations, balanced reciprocal translocations formed the largest group with 60% anomalies. We would conclude that clinicians should understand the importance of chromosomal analysis in these couples and refer them for karyotyping after two miscarriages to rule out the possible genetic cause of recurrent miscarriages. |
| doi_str_mv | 10.1007/s12041-016-0713-3 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859496034</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A717820660</galeid><sourcerecordid>A717820660</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-d335d7bcf3530cb6ae65589104d188a371658a3279c6673c03003db957803b8f3</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEoqXwA7ggS1w4NMXOJP7gVq0oVKoEBzhbjjNZvCT2Yjug_fc4bKkAgYQsa2zPM69mxlNVTxm9YJSKl4k1tGU1ZbymgkEN96pTqgTUQgC7X860aWoGACfVo5R261XQ5mF10gilWibFafV5c8hhix6zs8R4Mx2SS8R5YsOynzCRby5_IhHtEiP6TGaXrInRmS2mV8QUT44h7dFm9xVJystwIGMMM3m_-J3pz4kPsQhc-8GZx9WD0UwJn9zas-rj1esPm7f1zbs315vLm9q2osn1ANANorcjdEBtzw3yrpOK0XZgUhoQjHfFlBos5wIsBUph6FUnJIVejnBWvTjq7mP4smDKes0ap8l4DEvSTHaqVZxC-z8oaxQXUhb0-R_oLiyxdOwHVZIAVfYdtTUTaufHkKOxq6i-FEzIhnK-Uhd_ocoacHY2eBxdef8tgB0DbOl2ijjqfXSziQfNqF5nQR9nQZdZ0OssaCgxz24TXvoZh7uIn59fgOYIpOLyW4y_VPRP1e8HPrwH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1850303930</pqid></control><display><type>article</type><title>Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Indian Academy of Sciences</source><source>Springer Nature - Complete Springer Journals</source><creator>SUDHIR, NEHA ; KAUR, TAJINDER ; BERI, ARCHANA ; KAUR, ANUPAM</creator><creatorcontrib>SUDHIR, NEHA ; KAUR, TAJINDER ; BERI, ARCHANA ; KAUR, ANUPAM</creatorcontrib><description>Human reproduction is considered as the most inefficient event as ∼15–20% of human pregnancies end in miscarriage and in the product of miscarriages, chromosomal anomalies are a common occurrence. The aim of the present retrospective study was to assess the frequency of chromosomal aberrations in couples with recurrent miscarriages in the region of Punjab and to compare with worldwide frequencies. In this study, a total of 440 cases were referred between the period 1995–2015. After lymphocyte culturing, giemsa–trypsin banding was done for each case to assess the chromosomal anomalies. The frequency of chromosomal aberrations among couples was found to be 3.41% in our study. Among these aberrations, balanced reciprocal translocations formed the largest group with 60% anomalies. We would conclude that clinicians should understand the importance of chromosomal analysis in these couples and refer them for karyotyping after two miscarriages to rule out the possible genetic cause of recurrent miscarriages.</description><identifier>ISSN: 0022-1333</identifier><identifier>EISSN: 0973-7731</identifier><identifier>DOI: 10.1007/s12041-016-0713-3</identifier><identifier>PMID: 27994187</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Abortion, Habitual - diagnosis ; Abortion, Habitual - epidemiology ; Abortion, Habitual - etiology ; Abortion, Habitual - genetics ; Adult ; Animal Genetics and Genomics ; Biomedical and Life Sciences ; Chromosome Aberrations ; Chromosome Banding ; Chromosomes ; Couples ; Cytogenetic Analysis ; Cytogenetics ; Evolutionary Biology ; Female ; Humans ; India - epidemiology ; Karyotype ; Karyotyping ; Life Sciences ; Male ; Microbial Genetics and Genomics ; Middle Aged ; Miscarriage ; Phenotype ; Plant Genetics and Genomics ; Pregnancy ; Reproduction ; Research Article ; Retrospective Studies ; Young Adult</subject><ispartof>Journal of genetics, 2016-12, Vol.95 (4), p.887-894</ispartof><rights>Indian Academy of Sciences 2016</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Journal of Genetics is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-d335d7bcf3530cb6ae65589104d188a371658a3279c6673c03003db957803b8f3</citedby><cites>FETCH-LOGICAL-c472t-d335d7bcf3530cb6ae65589104d188a371658a3279c6673c03003db957803b8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12041-016-0713-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12041-016-0713-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27994187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUDHIR, NEHA</creatorcontrib><creatorcontrib>KAUR, TAJINDER</creatorcontrib><creatorcontrib>BERI, ARCHANA</creatorcontrib><creatorcontrib>KAUR, ANUPAM</creatorcontrib><title>Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India</title><title>Journal of genetics</title><addtitle>J Genet</addtitle><addtitle>J Genet</addtitle><description>Human reproduction is considered as the most inefficient event as ∼15–20% of human pregnancies end in miscarriage and in the product of miscarriages, chromosomal anomalies are a common occurrence. The aim of the present retrospective study was to assess the frequency of chromosomal aberrations in couples with recurrent miscarriages in the region of Punjab and to compare with worldwide frequencies. In this study, a total of 440 cases were referred between the period 1995–2015. After lymphocyte culturing, giemsa–trypsin banding was done for each case to assess the chromosomal anomalies. The frequency of chromosomal aberrations among couples was found to be 3.41% in our study. Among these aberrations, balanced reciprocal translocations formed the largest group with 60% anomalies. We would conclude that clinicians should understand the importance of chromosomal analysis in these couples and refer them for karyotyping after two miscarriages to rule out the possible genetic cause of recurrent miscarriages.</description><subject>Abortion, Habitual - diagnosis</subject><subject>Abortion, Habitual - epidemiology</subject><subject>Abortion, Habitual - etiology</subject><subject>Abortion, Habitual - genetics</subject><subject>Adult</subject><subject>Animal Genetics and Genomics</subject><subject>Biomedical and Life Sciences</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Banding</subject><subject>Chromosomes</subject><subject>Couples</subject><subject>Cytogenetic Analysis</subject><subject>Cytogenetics</subject><subject>Evolutionary Biology</subject><subject>Female</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Karyotype</subject><subject>Karyotyping</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Microbial Genetics and Genomics</subject><subject>Middle Aged</subject><subject>Miscarriage</subject><subject>Phenotype</subject><subject>Plant Genetics and Genomics</subject><subject>Pregnancy</subject><subject>Reproduction</subject><subject>Research Article</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>0022-1333</issn><issn>0973-7731</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk1v1DAQhiMEoqXwA7ggS1w4NMXOJP7gVq0oVKoEBzhbjjNZvCT2Yjug_fc4bKkAgYQsa2zPM69mxlNVTxm9YJSKl4k1tGU1ZbymgkEN96pTqgTUQgC7X860aWoGACfVo5R261XQ5mF10gilWibFafV5c8hhix6zs8R4Mx2SS8R5YsOynzCRby5_IhHtEiP6TGaXrInRmS2mV8QUT44h7dFm9xVJystwIGMMM3m_-J3pz4kPsQhc-8GZx9WD0UwJn9zas-rj1esPm7f1zbs315vLm9q2osn1ANANorcjdEBtzw3yrpOK0XZgUhoQjHfFlBos5wIsBUph6FUnJIVejnBWvTjq7mP4smDKes0ap8l4DEvSTHaqVZxC-z8oaxQXUhb0-R_oLiyxdOwHVZIAVfYdtTUTaufHkKOxq6i-FEzIhnK-Uhd_ocoacHY2eBxdef8tgB0DbOl2ijjqfXSziQfNqF5nQR9nQZdZ0OssaCgxz24TXvoZh7uIn59fgOYIpOLyW4y_VPRP1e8HPrwH</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>SUDHIR, NEHA</creator><creator>KAUR, TAJINDER</creator><creator>BERI, ARCHANA</creator><creator>KAUR, ANUPAM</creator><general>Springer India</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India</title><author>SUDHIR, NEHA ; KAUR, TAJINDER ; BERI, ARCHANA ; KAUR, ANUPAM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-d335d7bcf3530cb6ae65589104d188a371658a3279c6673c03003db957803b8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abortion, Habitual - diagnosis</topic><topic>Abortion, Habitual - epidemiology</topic><topic>Abortion, Habitual - etiology</topic><topic>Abortion, Habitual - genetics</topic><topic>Adult</topic><topic>Animal Genetics and Genomics</topic><topic>Biomedical and Life Sciences</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Banding</topic><topic>Chromosomes</topic><topic>Couples</topic><topic>Cytogenetic Analysis</topic><topic>Cytogenetics</topic><topic>Evolutionary Biology</topic><topic>Female</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Karyotype</topic><topic>Karyotyping</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Microbial Genetics and Genomics</topic><topic>Middle Aged</topic><topic>Miscarriage</topic><topic>Phenotype</topic><topic>Plant Genetics and Genomics</topic><topic>Pregnancy</topic><topic>Reproduction</topic><topic>Research Article</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUDHIR, NEHA</creatorcontrib><creatorcontrib>KAUR, TAJINDER</creatorcontrib><creatorcontrib>BERI, ARCHANA</creatorcontrib><creatorcontrib>KAUR, ANUPAM</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUDHIR, NEHA</au><au>KAUR, TAJINDER</au><au>BERI, ARCHANA</au><au>KAUR, ANUPAM</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India</atitle><jtitle>Journal of genetics</jtitle><stitle>J Genet</stitle><addtitle>J Genet</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>95</volume><issue>4</issue><spage>887</spage><epage>894</epage><pages>887-894</pages><issn>0022-1333</issn><eissn>0973-7731</eissn><abstract>Human reproduction is considered as the most inefficient event as ∼15–20% of human pregnancies end in miscarriage and in the product of miscarriages, chromosomal anomalies are a common occurrence. The aim of the present retrospective study was to assess the frequency of chromosomal aberrations in couples with recurrent miscarriages in the region of Punjab and to compare with worldwide frequencies. In this study, a total of 440 cases were referred between the period 1995–2015. After lymphocyte culturing, giemsa–trypsin banding was done for each case to assess the chromosomal anomalies. The frequency of chromosomal aberrations among couples was found to be 3.41% in our study. Among these aberrations, balanced reciprocal translocations formed the largest group with 60% anomalies. We would conclude that clinicians should understand the importance of chromosomal analysis in these couples and refer them for karyotyping after two miscarriages to rule out the possible genetic cause of recurrent miscarriages.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>27994187</pmid><doi>10.1007/s12041-016-0713-3</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1333 |
| ispartof | Journal of genetics, 2016-12, Vol.95 (4), p.887-894 |
| issn | 0022-1333 0973-7731 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1859496034 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Indian Academy of Sciences; Springer Nature - Complete Springer Journals |
| subjects | Abortion, Habitual - diagnosis Abortion, Habitual - epidemiology Abortion, Habitual - etiology Abortion, Habitual - genetics Adult Animal Genetics and Genomics Biomedical and Life Sciences Chromosome Aberrations Chromosome Banding Chromosomes Couples Cytogenetic Analysis Cytogenetics Evolutionary Biology Female Humans India - epidemiology Karyotype Karyotyping Life Sciences Male Microbial Genetics and Genomics Middle Aged Miscarriage Phenotype Plant Genetics and Genomics Pregnancy Reproduction Research Article Retrospective Studies Young Adult |
| title | Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T04%3A44%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytogenetic%20analysis%20in%20couples%20with%20recurrent%20miscarriages:%20a%20retrospective%20study%20from%20Punjab,%20north%20India&rft.jtitle=Journal%20of%20genetics&rft.au=SUDHIR,%20NEHA&rft.date=2016-12-01&rft.volume=95&rft.issue=4&rft.spage=887&rft.epage=894&rft.pages=887-894&rft.issn=0022-1333&rft.eissn=0973-7731&rft_id=info:doi/10.1007/s12041-016-0713-3&rft_dat=%3Cgale_proqu%3EA717820660%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1850303930&rft_id=info:pmid/27994187&rft_galeid=A717820660&rfr_iscdi=true |