Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID)

Highlights • Neuroinflammation is the earliest pathological event in a model of vascular cognitive impairment. • Astrocytic end-feet degenerate along the same time-course as the microhemorrhage occurrence. • Cognitive impairment progresses along the same time-course as the astrocytic end-foot degene...

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Veröffentlicht in:	Neuroscience 2017-01, Vol.341, p.42-51
Hauptverfasser:	Sudduth, Tiffany L, Weekman, Erica M, Price, Brittani R, Gooch, Jennifer L, Woolums, Abigail, Norris, Christopher M, Wilcock, Donna M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals astrocyte Astrocytes - immunology Astrocytes - pathology Brain - blood supply Brain - immunology Brain - pathology CD11b Antigen - metabolism Cerebral Hemorrhage - immunology Cerebral Hemorrhage - pathology cerebrovascular Cognitive Dysfunction - immunology Cognitive Dysfunction - pathology dementia Dementia, Vascular - immunology Dementia, Vascular - pathology Disease Models, Animal Disease Progression Dystrophin - metabolism Gliosis - immunology Gliosis - pathology Hyperhomocysteinemia - immunology Hyperhomocysteinemia - pathology Interleukin-12 Subunit p35 - metabolism Interleukin-1beta - metabolism Interleukin-6 - metabolism Large-Conductance Calcium-Activated Potassium Channels - metabolism Maze Learning - physiology Mice, Inbred C57BL microhemorrhage neuroinflammation Neurology Potassium Channels, Inwardly Rectifying - metabolism Time Factors Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Highlights • Neuroinflammation is the earliest pathological event in a model of vascular cognitive impairment. • Astrocytic end-feet degenerate along the same time-course as the microhemorrhage occurrence. • Cognitive impairment progresses along the same time-course as the astrocytic end-foot degeneration and microhemorrhages.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.11.024