Revisiting a dogma: similar survival of patients with small bowel and gastric GIST. A population-based propensity score SEER analysis
Background The objective of the present analysis was to assess whether small bowel gastrointestinal stromal tumor (GIST) is associated with worse cancer-specific survival (CSS) and overall survival (OS) compared with gastric GIST on a population-based level. Patients and methods Data on patients age...
Gespeichert in:
| Veröffentlicht in: | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2017, Vol.20 (1), p.49-60 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 60 |
|---|---|
| container_issue | 1 |
| container_start_page | 49 |
| container_title | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association |
| container_volume | 20 |
| creator | Guller, Ulrich Tarantino, Ignazio Cerny, Thomas Ulrich, Alexis Schmied, Bruno M. Warschkow, Rene |
| description | Background
The objective of the present analysis was to assess whether small bowel gastrointestinal stromal tumor (GIST) is associated with worse cancer-specific survival (CSS) and overall survival (OS) compared with gastric GIST on a population-based level.
Patients and methods
Data on patients aged 18 years or older with histologically proven GIST was extracted from the SEER database from 1998 to 2011. OS and CSS for small bowel GIST were compared with OS and CSS for gastric GIST by application of adjusted and unadjusted Cox regression analyses and propensity score analyses.
Results
GIST were located in the stomach (
n
= 3011, 59 %), duodenum (
n
= 313, 6 %), jejunum/ileum (
n
= 1288, 25 %), colon (
n
= 139, 3 %), rectum (
n
= 172, 3 %), and extraviscerally (
n
= 173, 3 %). OS and CSS of patients with GIST in the duodenum [OS, HR 0.95, 95 % confidence interval (CI) 0.76–1.19; CSS, HR 0.99, 95 % CI 0.76–1.29] and in the jejunum/ileum (OS, HR 0.97, 95 % CI 0.85–1.10; CSS, HR = 0.95, 95 % CI 0.81–1.10) were similar to those of patients with gastric GIST in multivariate analyses. Conversely, OS and CSS of patients with GIST in the colon (OS, HR 1.40; 95 % CI 1.07–1.83; CSS, HR 1.89, 95 % CI 1.41–2.54) and in an extravisceral location (OS, HR 1.42, 95 % CI 1.14–1.77; CSS, HR = 1.43, 95 % CI 1.11–1.84) were significantly worse than those of patients with gastric GIST.
Conclusions
Contrary to common belief, OS and CSS of patients with small bowel GIST are not statistically different from those of patients with gastric GIST when adjustment is made for confounding variables on a population-based level. The prognosis of patients with nongastric GIST is worse because of a colonic and extravisceral GIST location. These findings have implications regarding adjuvant treatment of GIST patients. Hence, the dogma that small bowel GIST patients have worse prognosis than gastric GIST patients and therefore should receive adjuvant treatment to a greater extent must be revisited. |
| doi_str_mv | 10.1007/s10120-015-0571-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859487967</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4293152851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-1e285047b7fddec61970c093d151ebfcb1d6018175110940f5f47589a137a0cf3</originalsourceid><addsrcrecordid>eNqNkc1q3DAURkVpaNKkD9BNEXSTjVNdW7Ks7kKYpoFAIT9rIcvyVEG2XF17wjxA37uaTlJKoZCVBDrfdyUdQt4DOwPG5CcEBiUrGIiCCQlF9YocAa_qoqqYeP28LxUckreIDyyDCuo35LCsa654xY_Izxu38ehnP66poV1cD-YzRT_4YBLFJW38xgQaezqZ2btxRvro5-8UBxMCbeOjC9SMHV0bnJO39PLq9u6MntMpTkvIiTgWrUHX0SnFyY150JaijcnR29XqJkdN2KLHE3LQm4Du3dN6TO6_rO4uvhbX3y6vLs6vC8tlORfgykYwLlvZd52zNSjJLFNVBwJc29sWuppBA1IAMMVZL3ouRaMMVNIw21fH5HTfm6_zY3E468GjdSGY0cUFNTRC8UaqWr4A3X1irZo6ox__QR_ikvLTfheKUvKmgUzBnrIpIibX6yn5waStBqZ3OvVep86W9E6nrnLmw1Pz0g6u-5N49peBcg9gPhrXLv01-r-tvwA1ZKnP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1855274881</pqid></control><display><type>article</type><title>Revisiting a dogma: similar survival of patients with small bowel and gastric GIST. A population-based propensity score SEER analysis</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Guller, Ulrich ; Tarantino, Ignazio ; Cerny, Thomas ; Ulrich, Alexis ; Schmied, Bruno M. ; Warschkow, Rene</creator><creatorcontrib>Guller, Ulrich ; Tarantino, Ignazio ; Cerny, Thomas ; Ulrich, Alexis ; Schmied, Bruno M. ; Warschkow, Rene</creatorcontrib><description>Background
The objective of the present analysis was to assess whether small bowel gastrointestinal stromal tumor (GIST) is associated with worse cancer-specific survival (CSS) and overall survival (OS) compared with gastric GIST on a population-based level.
Patients and methods
Data on patients aged 18 years or older with histologically proven GIST was extracted from the SEER database from 1998 to 2011. OS and CSS for small bowel GIST were compared with OS and CSS for gastric GIST by application of adjusted and unadjusted Cox regression analyses and propensity score analyses.
Results
GIST were located in the stomach (
n
= 3011, 59 %), duodenum (
n
= 313, 6 %), jejunum/ileum (
n
= 1288, 25 %), colon (
n
= 139, 3 %), rectum (
n
= 172, 3 %), and extraviscerally (
n
= 173, 3 %). OS and CSS of patients with GIST in the duodenum [OS, HR 0.95, 95 % confidence interval (CI) 0.76–1.19; CSS, HR 0.99, 95 % CI 0.76–1.29] and in the jejunum/ileum (OS, HR 0.97, 95 % CI 0.85–1.10; CSS, HR = 0.95, 95 % CI 0.81–1.10) were similar to those of patients with gastric GIST in multivariate analyses. Conversely, OS and CSS of patients with GIST in the colon (OS, HR 1.40; 95 % CI 1.07–1.83; CSS, HR 1.89, 95 % CI 1.41–2.54) and in an extravisceral location (OS, HR 1.42, 95 % CI 1.14–1.77; CSS, HR = 1.43, 95 % CI 1.11–1.84) were significantly worse than those of patients with gastric GIST.
Conclusions
Contrary to common belief, OS and CSS of patients with small bowel GIST are not statistically different from those of patients with gastric GIST when adjustment is made for confounding variables on a population-based level. The prognosis of patients with nongastric GIST is worse because of a colonic and extravisceral GIST location. These findings have implications regarding adjuvant treatment of GIST patients. Hence, the dogma that small bowel GIST patients have worse prognosis than gastric GIST patients and therefore should receive adjuvant treatment to a greater extent must be revisited.</description><identifier>ISSN: 1436-3291</identifier><identifier>EISSN: 1436-3305</identifier><identifier>DOI: 10.1007/s10120-015-0571-3</identifier><identifier>PMID: 26649434</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Adenocarcinoma - epidemiology ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cancer Research ; Cohort Studies ; Female ; Follow-Up Studies ; Gastric cancer ; Gastroenterology ; Gastrointestinal Stromal Tumors - epidemiology ; Gastrointestinal Stromal Tumors - mortality ; Gastrointestinal Stromal Tumors - pathology ; Gastrointestinal Stromal Tumors - surgery ; Humans ; Intestinal Neoplasms - epidemiology ; Intestinal Neoplasms - mortality ; Intestinal Neoplasms - pathology ; Intestinal Neoplasms - surgery ; Intestine, Small - pathology ; Intestine, Small - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Oncology ; Original Article ; Prognosis ; Propensity Score ; SEER Program ; Stomach Neoplasms - epidemiology ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Surgical Oncology ; Survival Rate ; United States - epidemiology ; Young Adult</subject><ispartof>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2017, Vol.20 (1), p.49-60</ispartof><rights>The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2015</rights><rights>Gastric Cancer is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-1e285047b7fddec61970c093d151ebfcb1d6018175110940f5f47589a137a0cf3</citedby><cites>FETCH-LOGICAL-c472t-1e285047b7fddec61970c093d151ebfcb1d6018175110940f5f47589a137a0cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10120-015-0571-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10120-015-0571-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26649434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guller, Ulrich</creatorcontrib><creatorcontrib>Tarantino, Ignazio</creatorcontrib><creatorcontrib>Cerny, Thomas</creatorcontrib><creatorcontrib>Ulrich, Alexis</creatorcontrib><creatorcontrib>Schmied, Bruno M.</creatorcontrib><creatorcontrib>Warschkow, Rene</creatorcontrib><title>Revisiting a dogma: similar survival of patients with small bowel and gastric GIST. A population-based propensity score SEER analysis</title><title>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</title><addtitle>Gastric Cancer</addtitle><addtitle>Gastric Cancer</addtitle><description>Background
The objective of the present analysis was to assess whether small bowel gastrointestinal stromal tumor (GIST) is associated with worse cancer-specific survival (CSS) and overall survival (OS) compared with gastric GIST on a population-based level.
Patients and methods
Data on patients aged 18 years or older with histologically proven GIST was extracted from the SEER database from 1998 to 2011. OS and CSS for small bowel GIST were compared with OS and CSS for gastric GIST by application of adjusted and unadjusted Cox regression analyses and propensity score analyses.
Results
GIST were located in the stomach (
n
= 3011, 59 %), duodenum (
n
= 313, 6 %), jejunum/ileum (
n
= 1288, 25 %), colon (
n
= 139, 3 %), rectum (
n
= 172, 3 %), and extraviscerally (
n
= 173, 3 %). OS and CSS of patients with GIST in the duodenum [OS, HR 0.95, 95 % confidence interval (CI) 0.76–1.19; CSS, HR 0.99, 95 % CI 0.76–1.29] and in the jejunum/ileum (OS, HR 0.97, 95 % CI 0.85–1.10; CSS, HR = 0.95, 95 % CI 0.81–1.10) were similar to those of patients with gastric GIST in multivariate analyses. Conversely, OS and CSS of patients with GIST in the colon (OS, HR 1.40; 95 % CI 1.07–1.83; CSS, HR 1.89, 95 % CI 1.41–2.54) and in an extravisceral location (OS, HR 1.42, 95 % CI 1.14–1.77; CSS, HR = 1.43, 95 % CI 1.11–1.84) were significantly worse than those of patients with gastric GIST.
Conclusions
Contrary to common belief, OS and CSS of patients with small bowel GIST are not statistically different from those of patients with gastric GIST when adjustment is made for confounding variables on a population-based level. The prognosis of patients with nongastric GIST is worse because of a colonic and extravisceral GIST location. These findings have implications regarding adjuvant treatment of GIST patients. Hence, the dogma that small bowel GIST patients have worse prognosis than gastric GIST patients and therefore should receive adjuvant treatment to a greater extent must be revisited.</description><subject>Abdominal Surgery</subject><subject>Adenocarcinoma - epidemiology</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer Research</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastric cancer</subject><subject>Gastroenterology</subject><subject>Gastrointestinal Stromal Tumors - epidemiology</subject><subject>Gastrointestinal Stromal Tumors - mortality</subject><subject>Gastrointestinal Stromal Tumors - pathology</subject><subject>Gastrointestinal Stromal Tumors - surgery</subject><subject>Humans</subject><subject>Intestinal Neoplasms - epidemiology</subject><subject>Intestinal Neoplasms - mortality</subject><subject>Intestinal Neoplasms - pathology</subject><subject>Intestinal Neoplasms - surgery</subject><subject>Intestine, Small - pathology</subject><subject>Intestine, Small - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Propensity Score</subject><subject>SEER Program</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>United States - epidemiology</subject><subject>Young Adult</subject><issn>1436-3291</issn><issn>1436-3305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkc1q3DAURkVpaNKkD9BNEXSTjVNdW7Ks7kKYpoFAIT9rIcvyVEG2XF17wjxA37uaTlJKoZCVBDrfdyUdQt4DOwPG5CcEBiUrGIiCCQlF9YocAa_qoqqYeP28LxUckreIDyyDCuo35LCsa654xY_Izxu38ehnP66poV1cD-YzRT_4YBLFJW38xgQaezqZ2btxRvro5-8UBxMCbeOjC9SMHV0bnJO39PLq9u6MntMpTkvIiTgWrUHX0SnFyY150JaijcnR29XqJkdN2KLHE3LQm4Du3dN6TO6_rO4uvhbX3y6vLs6vC8tlORfgykYwLlvZd52zNSjJLFNVBwJc29sWuppBA1IAMMVZL3ouRaMMVNIw21fH5HTfm6_zY3E468GjdSGY0cUFNTRC8UaqWr4A3X1irZo6ox__QR_ikvLTfheKUvKmgUzBnrIpIibX6yn5waStBqZ3OvVep86W9E6nrnLmw1Pz0g6u-5N49peBcg9gPhrXLv01-r-tvwA1ZKnP</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Guller, Ulrich</creator><creator>Tarantino, Ignazio</creator><creator>Cerny, Thomas</creator><creator>Ulrich, Alexis</creator><creator>Schmied, Bruno M.</creator><creator>Warschkow, Rene</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Revisiting a dogma: similar survival of patients with small bowel and gastric GIST. A population-based propensity score SEER analysis</title><author>Guller, Ulrich ; Tarantino, Ignazio ; Cerny, Thomas ; Ulrich, Alexis ; Schmied, Bruno M. ; Warschkow, Rene</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-1e285047b7fddec61970c093d151ebfcb1d6018175110940f5f47589a137a0cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdominal Surgery</topic><topic>Adenocarcinoma - epidemiology</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer Research</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastric cancer</topic><topic>Gastroenterology</topic><topic>Gastrointestinal Stromal Tumors - epidemiology</topic><topic>Gastrointestinal Stromal Tumors - mortality</topic><topic>Gastrointestinal Stromal Tumors - pathology</topic><topic>Gastrointestinal Stromal Tumors - surgery</topic><topic>Humans</topic><topic>Intestinal Neoplasms - epidemiology</topic><topic>Intestinal Neoplasms - mortality</topic><topic>Intestinal Neoplasms - pathology</topic><topic>Intestinal Neoplasms - surgery</topic><topic>Intestine, Small - pathology</topic><topic>Intestine, Small - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Propensity Score</topic><topic>SEER Program</topic><topic>Stomach Neoplasms - epidemiology</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>United States - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guller, Ulrich</creatorcontrib><creatorcontrib>Tarantino, Ignazio</creatorcontrib><creatorcontrib>Cerny, Thomas</creatorcontrib><creatorcontrib>Ulrich, Alexis</creatorcontrib><creatorcontrib>Schmied, Bruno M.</creatorcontrib><creatorcontrib>Warschkow, Rene</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guller, Ulrich</au><au>Tarantino, Ignazio</au><au>Cerny, Thomas</au><au>Ulrich, Alexis</au><au>Schmied, Bruno M.</au><au>Warschkow, Rene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Revisiting a dogma: similar survival of patients with small bowel and gastric GIST. A population-based propensity score SEER analysis</atitle><jtitle>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</jtitle><stitle>Gastric Cancer</stitle><addtitle>Gastric Cancer</addtitle><date>2017</date><risdate>2017</risdate><volume>20</volume><issue>1</issue><spage>49</spage><epage>60</epage><pages>49-60</pages><issn>1436-3291</issn><eissn>1436-3305</eissn><abstract>Background
The objective of the present analysis was to assess whether small bowel gastrointestinal stromal tumor (GIST) is associated with worse cancer-specific survival (CSS) and overall survival (OS) compared with gastric GIST on a population-based level.
Patients and methods
Data on patients aged 18 years or older with histologically proven GIST was extracted from the SEER database from 1998 to 2011. OS and CSS for small bowel GIST were compared with OS and CSS for gastric GIST by application of adjusted and unadjusted Cox regression analyses and propensity score analyses.
Results
GIST were located in the stomach (
n
= 3011, 59 %), duodenum (
n
= 313, 6 %), jejunum/ileum (
n
= 1288, 25 %), colon (
n
= 139, 3 %), rectum (
n
= 172, 3 %), and extraviscerally (
n
= 173, 3 %). OS and CSS of patients with GIST in the duodenum [OS, HR 0.95, 95 % confidence interval (CI) 0.76–1.19; CSS, HR 0.99, 95 % CI 0.76–1.29] and in the jejunum/ileum (OS, HR 0.97, 95 % CI 0.85–1.10; CSS, HR = 0.95, 95 % CI 0.81–1.10) were similar to those of patients with gastric GIST in multivariate analyses. Conversely, OS and CSS of patients with GIST in the colon (OS, HR 1.40; 95 % CI 1.07–1.83; CSS, HR 1.89, 95 % CI 1.41–2.54) and in an extravisceral location (OS, HR 1.42, 95 % CI 1.14–1.77; CSS, HR = 1.43, 95 % CI 1.11–1.84) were significantly worse than those of patients with gastric GIST.
Conclusions
Contrary to common belief, OS and CSS of patients with small bowel GIST are not statistically different from those of patients with gastric GIST when adjustment is made for confounding variables on a population-based level. The prognosis of patients with nongastric GIST is worse because of a colonic and extravisceral GIST location. These findings have implications regarding adjuvant treatment of GIST patients. Hence, the dogma that small bowel GIST patients have worse prognosis than gastric GIST patients and therefore should receive adjuvant treatment to a greater extent must be revisited.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>26649434</pmid><doi>10.1007/s10120-015-0571-3</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-3291 |
| ispartof | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2017, Vol.20 (1), p.49-60 |
| issn | 1436-3291 1436-3305 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1859487967 |
| source | MEDLINE; SpringerLink Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Abdominal Surgery Adenocarcinoma - epidemiology Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery Adolescent Adult Aged Aged, 80 and over Cancer Research Cohort Studies Female Follow-Up Studies Gastric cancer Gastroenterology Gastrointestinal Stromal Tumors - epidemiology Gastrointestinal Stromal Tumors - mortality Gastrointestinal Stromal Tumors - pathology Gastrointestinal Stromal Tumors - surgery Humans Intestinal Neoplasms - epidemiology Intestinal Neoplasms - mortality Intestinal Neoplasms - pathology Intestinal Neoplasms - surgery Intestine, Small - pathology Intestine, Small - surgery Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Neoplasm Staging Oncology Original Article Prognosis Propensity Score SEER Program Stomach Neoplasms - epidemiology Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery Surgical Oncology Survival Rate United States - epidemiology Young Adult |
| title | Revisiting a dogma: similar survival of patients with small bowel and gastric GIST. A population-based propensity score SEER analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T07%3A25%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Revisiting%20a%20dogma:%20similar%20survival%20of%20patients%20with%20small%20bowel%20and%20gastric%20GIST.%20A%20population-based%20propensity%20score%20SEER%20analysis&rft.jtitle=Gastric%20cancer%20:%20official%20journal%20of%20the%20International%20Gastric%20Cancer%20Association%20and%20the%20Japanese%20Gastric%20Cancer%20Association&rft.au=Guller,%20Ulrich&rft.date=2017&rft.volume=20&rft.issue=1&rft.spage=49&rft.epage=60&rft.pages=49-60&rft.issn=1436-3291&rft.eissn=1436-3305&rft_id=info:doi/10.1007/s10120-015-0571-3&rft_dat=%3Cproquest_cross%3E4293152851%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1855274881&rft_id=info:pmid/26649434&rfr_iscdi=true |