CONUT: a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection
Background Controlling nutritional status (CONUT) score, calculated from serum albumin and total cholesterol concentrations and total lymphocyte count, is reportedly valuable for nutritional assessment. This study investigated whether CONUT score was predictive of outcomes in colorectal cancer (CRC)...
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| Veröffentlicht in: | International journal of colorectal disease 2017, Vol.32 (1), p.99-106 |
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| container_title | International journal of colorectal disease |
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| creator | Tokunaga, Ryuma Sakamoto, Yasuo Nakagawa, Shigeki Ohuchi, Mayuko Izumi, Daisuke Kosumi, Keisuke Taki, Katsunobu Higashi, Takaaki Miyamoto, Yuji Yoshida, Naoya Oki, Eiji Watanabe, Masayuki Baba, Hideo |
| description | Background
Controlling nutritional status (CONUT) score, calculated from serum albumin and total cholesterol concentrations and total lymphocyte count, is reportedly valuable for nutritional assessment. This study investigated whether CONUT score was predictive of outcomes in colorectal cancer (CRC) patients undergoing surgical resection.
Methods
Preoperative CONUT scores were retrospectively evaluated in 417 CRC patients who underwent potentially curative resection at Kumamoto University Hospital from March 2005 to August 2014. Patients were divided into four groups based on preoperative CONUT scores: normal, light, moderate, and severe. The associations of CONUT score with clinicopathological factors, patient survival, and postoperative complications were examined.
Results
CONUT score correlated significantly with age (
P
|
| doi_str_mv | 10.1007/s00384-016-2668-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859486994</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714488896</galeid><sourcerecordid>A714488896</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-d502a85489e97a17aa0f56e408b1d83685bc20a5dc5cc8b68862c04422c184a63</originalsourceid><addsrcrecordid>eNqNkltrFTEUhYMo9lj9Ab5IwBdfpiaZ3Ma3cvAGxb60zyEns-eQkpOMSabQf9-Mp15RkEAuO99a7A0LoZeUnFFC1NtCSK95R6jsmJS6E4_QhvKedZRJ9hhtCFVDRwehT9CzUm5Ie0vFn6ITphSThPINqtvLL9dX77DFMd1CwD6OMEPbYsVzhtG76m8BF5cy4Cll7FJoV1dtwM5GBxnPtvqGF7w0Wd4nH_d4TrWVvA3hDrsl228mGUoT-hSfoyeTDQVePJyn6PrD-6vtp-7i8uPn7flF57hitRsFYVYLrgcYlKXKWjIJCZzoHR11L7XYOUasGJ1wTu-k1pI5wjljjmpuZX-K3hx955y-LlCqOfjiIAQbIS3FUC0GruUw8P9Ae9ErPfSkoa__QG_SkmMbZDWUjHJJ1U9qbwMYH6dUs3WrqTlXlHOt9bB2ePYXqq0RDt6lCJNv9d8E9ChwOZWSYTJz9geb7wwlZg2FOYbCtFCYNRRGNM2rh4aX3QHGH4rvKWgAOwKlfcU95F8m-qfrPRZPwH0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1856214617</pqid></control><display><type>article</type><title>CONUT: a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Tokunaga, Ryuma ; Sakamoto, Yasuo ; Nakagawa, Shigeki ; Ohuchi, Mayuko ; Izumi, Daisuke ; Kosumi, Keisuke ; Taki, Katsunobu ; Higashi, Takaaki ; Miyamoto, Yuji ; Yoshida, Naoya ; Oki, Eiji ; Watanabe, Masayuki ; Baba, Hideo</creator><creatorcontrib>Tokunaga, Ryuma ; Sakamoto, Yasuo ; Nakagawa, Shigeki ; Ohuchi, Mayuko ; Izumi, Daisuke ; Kosumi, Keisuke ; Taki, Katsunobu ; Higashi, Takaaki ; Miyamoto, Yuji ; Yoshida, Naoya ; Oki, Eiji ; Watanabe, Masayuki ; Baba, Hideo</creatorcontrib><description>Background
Controlling nutritional status (CONUT) score, calculated from serum albumin and total cholesterol concentrations and total lymphocyte count, is reportedly valuable for nutritional assessment. This study investigated whether CONUT score was predictive of outcomes in colorectal cancer (CRC) patients undergoing surgical resection.
Methods
Preoperative CONUT scores were retrospectively evaluated in 417 CRC patients who underwent potentially curative resection at Kumamoto University Hospital from March 2005 to August 2014. Patients were divided into four groups based on preoperative CONUT scores: normal, light, moderate, and severe. The associations of CONUT score with clinicopathological factors, patient survival, and postoperative complications were examined.
Results
CONUT score correlated significantly with age (
P
< 0.001), body mass index (
P
= 0.005), carcinoembryonic antigen (
P
= 0.002), and carbohydrate antigen 19-9 (
P
= 0.005) concentrations. Overall survival (OS) rate was significantly lower in patients with moderate/severe than light or normal CONUT scores. CONUT score was independently prognostic of OS [moderate/severe vs. normal, hazard ratio = 5.92, 95 % confidence interval (CI) 2.30–14.92;
P
< 0.001)]. Patients with moderate/severe CONUT scores were at greater risk for complications, especially for severe complications. Multivariate analysis showed that CONUT score was independently predictive of severe complications (moderate/severe vs. normal, odds ratio = 4.51, 95 % CI 1.89–10.74;
P
< 0.001).
Conclusions
CONUT score may predict survival and postoperative severe complications in CRC patients undergoing potentially curative resection. Management of CRC patients may need consideration of host nutritional status.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-016-2668-5</identifier><identifier>PMID: 27726014</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Albumin ; Cancer patients ; Care and treatment ; CEA (Oncology) ; Colorectal cancer ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Digestive System Surgical Procedures ; Disease-Free Survival ; Female ; Gastroenterology ; Hepatology ; Hospital patients ; Humans ; Internal Medicine ; Logistic Models ; Lymphocytes - pathology ; Male ; Medical colleges ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Nutrition ; Nutritional Status ; Original Article ; Postoperative Complications - etiology ; Proctology ; Product/Service Evaluations ; Risk Factors ; Serum Albumin - metabolism ; Surgery ; Treatment Outcome ; Young Adult</subject><ispartof>International journal of colorectal disease, 2017, Vol.32 (1), p.99-106</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>COPYRIGHT 2017 Springer</rights><rights>International Journal of Colorectal Disease is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-d502a85489e97a17aa0f56e408b1d83685bc20a5dc5cc8b68862c04422c184a63</citedby><cites>FETCH-LOGICAL-c472t-d502a85489e97a17aa0f56e408b1d83685bc20a5dc5cc8b68862c04422c184a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-016-2668-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-016-2668-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27726014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tokunaga, Ryuma</creatorcontrib><creatorcontrib>Sakamoto, Yasuo</creatorcontrib><creatorcontrib>Nakagawa, Shigeki</creatorcontrib><creatorcontrib>Ohuchi, Mayuko</creatorcontrib><creatorcontrib>Izumi, Daisuke</creatorcontrib><creatorcontrib>Kosumi, Keisuke</creatorcontrib><creatorcontrib>Taki, Katsunobu</creatorcontrib><creatorcontrib>Higashi, Takaaki</creatorcontrib><creatorcontrib>Miyamoto, Yuji</creatorcontrib><creatorcontrib>Yoshida, Naoya</creatorcontrib><creatorcontrib>Oki, Eiji</creatorcontrib><creatorcontrib>Watanabe, Masayuki</creatorcontrib><creatorcontrib>Baba, Hideo</creatorcontrib><title>CONUT: a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Background
Controlling nutritional status (CONUT) score, calculated from serum albumin and total cholesterol concentrations and total lymphocyte count, is reportedly valuable for nutritional assessment. This study investigated whether CONUT score was predictive of outcomes in colorectal cancer (CRC) patients undergoing surgical resection.
Methods
Preoperative CONUT scores were retrospectively evaluated in 417 CRC patients who underwent potentially curative resection at Kumamoto University Hospital from March 2005 to August 2014. Patients were divided into four groups based on preoperative CONUT scores: normal, light, moderate, and severe. The associations of CONUT score with clinicopathological factors, patient survival, and postoperative complications were examined.
Results
CONUT score correlated significantly with age (
P
< 0.001), body mass index (
P
= 0.005), carcinoembryonic antigen (
P
= 0.002), and carbohydrate antigen 19-9 (
P
= 0.005) concentrations. Overall survival (OS) rate was significantly lower in patients with moderate/severe than light or normal CONUT scores. CONUT score was independently prognostic of OS [moderate/severe vs. normal, hazard ratio = 5.92, 95 % confidence interval (CI) 2.30–14.92;
P
< 0.001)]. Patients with moderate/severe CONUT scores were at greater risk for complications, especially for severe complications. Multivariate analysis showed that CONUT score was independently predictive of severe complications (moderate/severe vs. normal, odds ratio = 4.51, 95 % CI 1.89–10.74;
P
< 0.001).
Conclusions
CONUT score may predict survival and postoperative severe complications in CRC patients undergoing potentially curative resection. Management of CRC patients may need consideration of host nutritional status.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Albumin</subject><subject>Cancer patients</subject><subject>Care and treatment</subject><subject>CEA (Oncology)</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Digestive System Surgical Procedures</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Hospital patients</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Logistic Models</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Medical colleges</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nutrition</subject><subject>Nutritional Status</subject><subject>Original Article</subject><subject>Postoperative Complications - etiology</subject><subject>Proctology</subject><subject>Product/Service Evaluations</subject><subject>Risk Factors</subject><subject>Serum Albumin - metabolism</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkltrFTEUhYMo9lj9Ab5IwBdfpiaZ3Ma3cvAGxb60zyEns-eQkpOMSabQf9-Mp15RkEAuO99a7A0LoZeUnFFC1NtCSK95R6jsmJS6E4_QhvKedZRJ9hhtCFVDRwehT9CzUm5Ie0vFn6ITphSThPINqtvLL9dX77DFMd1CwD6OMEPbYsVzhtG76m8BF5cy4Cll7FJoV1dtwM5GBxnPtvqGF7w0Wd4nH_d4TrWVvA3hDrsl228mGUoT-hSfoyeTDQVePJyn6PrD-6vtp-7i8uPn7flF57hitRsFYVYLrgcYlKXKWjIJCZzoHR11L7XYOUasGJ1wTu-k1pI5wjljjmpuZX-K3hx955y-LlCqOfjiIAQbIS3FUC0GruUw8P9Ae9ErPfSkoa__QG_SkmMbZDWUjHJJ1U9qbwMYH6dUs3WrqTlXlHOt9bB2ePYXqq0RDt6lCJNv9d8E9ChwOZWSYTJz9geb7wwlZg2FOYbCtFCYNRRGNM2rh4aX3QHGH4rvKWgAOwKlfcU95F8m-qfrPRZPwH0</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Tokunaga, Ryuma</creator><creator>Sakamoto, Yasuo</creator><creator>Nakagawa, Shigeki</creator><creator>Ohuchi, Mayuko</creator><creator>Izumi, Daisuke</creator><creator>Kosumi, Keisuke</creator><creator>Taki, Katsunobu</creator><creator>Higashi, Takaaki</creator><creator>Miyamoto, Yuji</creator><creator>Yoshida, Naoya</creator><creator>Oki, Eiji</creator><creator>Watanabe, Masayuki</creator><creator>Baba, Hideo</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>CONUT: a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection</title><author>Tokunaga, Ryuma ; Sakamoto, Yasuo ; Nakagawa, Shigeki ; Ohuchi, Mayuko ; Izumi, Daisuke ; Kosumi, Keisuke ; Taki, Katsunobu ; Higashi, Takaaki ; Miyamoto, Yuji ; Yoshida, Naoya ; Oki, Eiji ; Watanabe, Masayuki ; Baba, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-d502a85489e97a17aa0f56e408b1d83685bc20a5dc5cc8b68862c04422c184a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Albumin</topic><topic>Cancer patients</topic><topic>Care and treatment</topic><topic>CEA (Oncology)</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Digestive System Surgical Procedures</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Hospital patients</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Logistic Models</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Medical colleges</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nutrition</topic><topic>Nutritional Status</topic><topic>Original Article</topic><topic>Postoperative Complications - etiology</topic><topic>Proctology</topic><topic>Product/Service Evaluations</topic><topic>Risk Factors</topic><topic>Serum Albumin - metabolism</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tokunaga, Ryuma</creatorcontrib><creatorcontrib>Sakamoto, Yasuo</creatorcontrib><creatorcontrib>Nakagawa, Shigeki</creatorcontrib><creatorcontrib>Ohuchi, Mayuko</creatorcontrib><creatorcontrib>Izumi, Daisuke</creatorcontrib><creatorcontrib>Kosumi, Keisuke</creatorcontrib><creatorcontrib>Taki, Katsunobu</creatorcontrib><creatorcontrib>Higashi, Takaaki</creatorcontrib><creatorcontrib>Miyamoto, Yuji</creatorcontrib><creatorcontrib>Yoshida, Naoya</creatorcontrib><creatorcontrib>Oki, Eiji</creatorcontrib><creatorcontrib>Watanabe, Masayuki</creatorcontrib><creatorcontrib>Baba, Hideo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tokunaga, Ryuma</au><au>Sakamoto, Yasuo</au><au>Nakagawa, Shigeki</au><au>Ohuchi, Mayuko</au><au>Izumi, Daisuke</au><au>Kosumi, Keisuke</au><au>Taki, Katsunobu</au><au>Higashi, Takaaki</au><au>Miyamoto, Yuji</au><au>Yoshida, Naoya</au><au>Oki, Eiji</au><au>Watanabe, Masayuki</au><au>Baba, Hideo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CONUT: a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2017</date><risdate>2017</risdate><volume>32</volume><issue>1</issue><spage>99</spage><epage>106</epage><pages>99-106</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><abstract>Background
Controlling nutritional status (CONUT) score, calculated from serum albumin and total cholesterol concentrations and total lymphocyte count, is reportedly valuable for nutritional assessment. This study investigated whether CONUT score was predictive of outcomes in colorectal cancer (CRC) patients undergoing surgical resection.
Methods
Preoperative CONUT scores were retrospectively evaluated in 417 CRC patients who underwent potentially curative resection at Kumamoto University Hospital from March 2005 to August 2014. Patients were divided into four groups based on preoperative CONUT scores: normal, light, moderate, and severe. The associations of CONUT score with clinicopathological factors, patient survival, and postoperative complications were examined.
Results
CONUT score correlated significantly with age (
P
< 0.001), body mass index (
P
= 0.005), carcinoembryonic antigen (
P
= 0.002), and carbohydrate antigen 19-9 (
P
= 0.005) concentrations. Overall survival (OS) rate was significantly lower in patients with moderate/severe than light or normal CONUT scores. CONUT score was independently prognostic of OS [moderate/severe vs. normal, hazard ratio = 5.92, 95 % confidence interval (CI) 2.30–14.92;
P
< 0.001)]. Patients with moderate/severe CONUT scores were at greater risk for complications, especially for severe complications. Multivariate analysis showed that CONUT score was independently predictive of severe complications (moderate/severe vs. normal, odds ratio = 4.51, 95 % CI 1.89–10.74;
P
< 0.001).
Conclusions
CONUT score may predict survival and postoperative severe complications in CRC patients undergoing potentially curative resection. Management of CRC patients may need consideration of host nutritional status.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27726014</pmid><doi>10.1007/s00384-016-2668-5</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0179-1958 |
| ispartof | International journal of colorectal disease, 2017, Vol.32 (1), p.99-106 |
| issn | 0179-1958 1432-1262 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1859486994 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Aged Aged, 80 and over Albumin Cancer patients Care and treatment CEA (Oncology) Colorectal cancer Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Digestive System Surgical Procedures Disease-Free Survival Female Gastroenterology Hepatology Hospital patients Humans Internal Medicine Logistic Models Lymphocytes - pathology Male Medical colleges Medicine Medicine & Public Health Middle Aged Multivariate Analysis Nutrition Nutritional Status Original Article Postoperative Complications - etiology Proctology Product/Service Evaluations Risk Factors Serum Albumin - metabolism Surgery Treatment Outcome Young Adult |
| title | CONUT: a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection |
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