Lidocaine controls pain and allows safe wound bed preparation and debridement of digital ulcers in systemic sclerosis: a retrospective study
In Systemic Sclerosis (SSc), digital ulcers (DU) are painful, difficult to heal, and frequently infected. To reduce the risk of bacterial infection and to prevent chronicity, it is essential to carefully remove necrotic tissue from DU, with maximum patient comfort. Debridement, although very efficac...
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| Veröffentlicht in: | Clinical rheumatology 2017, Vol.36 (1), p.209-212 |
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| creator | Braschi, Francesca Bartoli, Francesca Bruni, Cosimo Fiori, Ginevra Fantauzzo, Claudia Paganelli, Lucia De Paulis, Amato Rasero, Laura Matucci-Cerinic, M. |
| description | In Systemic Sclerosis (SSc), digital ulcers (DU) are painful, difficult to heal, and frequently infected. To reduce the risk of bacterial infection and to prevent chronicity, it is essential to carefully remove necrotic tissue from DU, with maximum patient comfort. Debridement, although very efficacious, is invasive and causes local pain: lidocaine is a local anesthetic commonly used as to fight pain during debridement procedures. The aim of the study was to evaluate the efficacy of lidocaine 4 % in pain control during debridement procedure of DU in SSc. One hundred eight DU characterized by pain Numeric Rating Scale (NRS) >3/10 before starting the procedure were treated with lidocaine 4 % (lidocaine cloridrate 200 mg in 5 ml of injecting solution). Pain was measured with NRS (0–10) before starting debridement, after 15 min of lidocaine application and at the end of the procedure. In DU, in respect to baseline (mean NRS 6.74 ± 2.96), pain after application of lidocaine 4 % for 15 min was significantly lower (mean NRS 2.83 ± 2.73) (
p
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| doi_str_mv | 10.1007/s10067-016-3414-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859486644</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859486644</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-3b438efc2ac18372b3370900405a58fb579b43608d950ecbbd30c5862bea4c643</originalsourceid><addsrcrecordid>eNqNkc2KFTEQhYMoznX0AdxIwI2b1qSTzo87GfyDC250HdJJ9ZChu9Omuh3uO8xDm0uPIoLgJiGVr05R5xDynLPXnDH9BuupdMO4aoTkstEPyIFLIRtrpX1IDkxr1ghuzQV5gnjDGGuN5Y_JRauVUUrxA7k7ppiDTzPQkOe15BHpUp_Uz5H6ccy3SNEPQG_zVis9RLoUWHzxa8o7FaEvKcIE80rzQGO6Tqsf6TYGKEirFJ5whSkFimGEkjHhW-ppgToNFwhr-gEU1y2enpJHgx8Rnt3fl-Tbh_dfrz41xy8fP1-9OzZBCr42opfCwBBaH7gRuu2F0MwyJlnnOzP0nbaVUMxE2zEIfR8FC51RbQ9eBiXFJXm16y4lf98AVzclDDCOfoa8oeOms7IaJP8LVRWuplf05V_oTd7KXBc5U1113EhbKb5ToW6PBQa3lDT5cnKcuXOqbk_V1VTdOVWna8-Le-WtnyD-7vgVYwXaHcD6NV9D-WP0P1V_AleXrjY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1855686849</pqid></control><display><type>article</type><title>Lidocaine controls pain and allows safe wound bed preparation and debridement of digital ulcers in systemic sclerosis: a retrospective study</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Braschi, Francesca ; Bartoli, Francesca ; Bruni, Cosimo ; Fiori, Ginevra ; Fantauzzo, Claudia ; Paganelli, Lucia ; De Paulis, Amato ; Rasero, Laura ; Matucci-Cerinic, M.</creator><creatorcontrib>Braschi, Francesca ; Bartoli, Francesca ; Bruni, Cosimo ; Fiori, Ginevra ; Fantauzzo, Claudia ; Paganelli, Lucia ; De Paulis, Amato ; Rasero, Laura ; Matucci-Cerinic, M.</creatorcontrib><description>In Systemic Sclerosis (SSc), digital ulcers (DU) are painful, difficult to heal, and frequently infected. To reduce the risk of bacterial infection and to prevent chronicity, it is essential to carefully remove necrotic tissue from DU, with maximum patient comfort. Debridement, although very efficacious, is invasive and causes local pain: lidocaine is a local anesthetic commonly used as to fight pain during debridement procedures. The aim of the study was to evaluate the efficacy of lidocaine 4 % in pain control during debridement procedure of DU in SSc. One hundred eight DU characterized by pain Numeric Rating Scale (NRS) >3/10 before starting the procedure were treated with lidocaine 4 % (lidocaine cloridrate 200 mg in 5 ml of injecting solution). Pain was measured with NRS (0–10) before starting debridement, after 15 min of lidocaine application and at the end of the procedure. In DU, in respect to baseline (mean NRS 6.74 ± 2.96), pain after application of lidocaine 4 % for 15 min was significantly lower (mean NRS 2.83 ± 2.73) (
p
< 0.001). At the end of the procedure, pain control was still maintained and significantly lower (mean NRS 2.88 ± 2.65) in respect to baseline (
p
< 0.001). No systemic adverse event due to topical lidocaine were observed. In SSc, topical application of lidocaine 4 % significantly reduces pain, allowing a safe debridement procedure, thus improving the management of DU.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-016-3414-7</identifier><identifier>PMID: 27686661</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Aged ; Anesthetics, Local - therapeutic use ; Brief Report ; Debridement - methods ; Female ; Fingers - pathology ; Humans ; Lidocaine - therapeutic use ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Pain - drug therapy ; Pain Management ; Pain Measurement ; Retrospective Studies ; Rheumatology ; Scleroderma, Systemic - drug therapy ; Scleroderma, Systemic - surgery ; Skin Ulcer - therapy ; Wound Healing</subject><ispartof>Clinical rheumatology, 2017, Vol.36 (1), p.209-212</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2016</rights><rights>Clinical Rheumatology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-3b438efc2ac18372b3370900405a58fb579b43608d950ecbbd30c5862bea4c643</citedby><cites>FETCH-LOGICAL-c431t-3b438efc2ac18372b3370900405a58fb579b43608d950ecbbd30c5862bea4c643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-016-3414-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-016-3414-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27686661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braschi, Francesca</creatorcontrib><creatorcontrib>Bartoli, Francesca</creatorcontrib><creatorcontrib>Bruni, Cosimo</creatorcontrib><creatorcontrib>Fiori, Ginevra</creatorcontrib><creatorcontrib>Fantauzzo, Claudia</creatorcontrib><creatorcontrib>Paganelli, Lucia</creatorcontrib><creatorcontrib>De Paulis, Amato</creatorcontrib><creatorcontrib>Rasero, Laura</creatorcontrib><creatorcontrib>Matucci-Cerinic, M.</creatorcontrib><title>Lidocaine controls pain and allows safe wound bed preparation and debridement of digital ulcers in systemic sclerosis: a retrospective study</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>In Systemic Sclerosis (SSc), digital ulcers (DU) are painful, difficult to heal, and frequently infected. To reduce the risk of bacterial infection and to prevent chronicity, it is essential to carefully remove necrotic tissue from DU, with maximum patient comfort. Debridement, although very efficacious, is invasive and causes local pain: lidocaine is a local anesthetic commonly used as to fight pain during debridement procedures. The aim of the study was to evaluate the efficacy of lidocaine 4 % in pain control during debridement procedure of DU in SSc. One hundred eight DU characterized by pain Numeric Rating Scale (NRS) >3/10 before starting the procedure were treated with lidocaine 4 % (lidocaine cloridrate 200 mg in 5 ml of injecting solution). Pain was measured with NRS (0–10) before starting debridement, after 15 min of lidocaine application and at the end of the procedure. In DU, in respect to baseline (mean NRS 6.74 ± 2.96), pain after application of lidocaine 4 % for 15 min was significantly lower (mean NRS 2.83 ± 2.73) (
p
< 0.001). At the end of the procedure, pain control was still maintained and significantly lower (mean NRS 2.88 ± 2.65) in respect to baseline (
p
< 0.001). No systemic adverse event due to topical lidocaine were observed. In SSc, topical application of lidocaine 4 % significantly reduces pain, allowing a safe debridement procedure, thus improving the management of DU.</description><subject>Aged</subject><subject>Anesthetics, Local - therapeutic use</subject><subject>Brief Report</subject><subject>Debridement - methods</subject><subject>Female</subject><subject>Fingers - pathology</subject><subject>Humans</subject><subject>Lidocaine - therapeutic use</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Pain - drug therapy</subject><subject>Pain Management</subject><subject>Pain Measurement</subject><subject>Retrospective Studies</subject><subject>Rheumatology</subject><subject>Scleroderma, Systemic - drug therapy</subject><subject>Scleroderma, Systemic - surgery</subject><subject>Skin Ulcer - therapy</subject><subject>Wound Healing</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkc2KFTEQhYMoznX0AdxIwI2b1qSTzo87GfyDC250HdJJ9ZChu9Omuh3uO8xDm0uPIoLgJiGVr05R5xDynLPXnDH9BuupdMO4aoTkstEPyIFLIRtrpX1IDkxr1ghuzQV5gnjDGGuN5Y_JRauVUUrxA7k7ppiDTzPQkOe15BHpUp_Uz5H6ccy3SNEPQG_zVis9RLoUWHzxa8o7FaEvKcIE80rzQGO6Tqsf6TYGKEirFJ5whSkFimGEkjHhW-ppgToNFwhr-gEU1y2enpJHgx8Rnt3fl-Tbh_dfrz41xy8fP1-9OzZBCr42opfCwBBaH7gRuu2F0MwyJlnnOzP0nbaVUMxE2zEIfR8FC51RbQ9eBiXFJXm16y4lf98AVzclDDCOfoa8oeOms7IaJP8LVRWuplf05V_oTd7KXBc5U1113EhbKb5ToW6PBQa3lDT5cnKcuXOqbk_V1VTdOVWna8-Le-WtnyD-7vgVYwXaHcD6NV9D-WP0P1V_AleXrjY</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Braschi, Francesca</creator><creator>Bartoli, Francesca</creator><creator>Bruni, Cosimo</creator><creator>Fiori, Ginevra</creator><creator>Fantauzzo, Claudia</creator><creator>Paganelli, Lucia</creator><creator>De Paulis, Amato</creator><creator>Rasero, Laura</creator><creator>Matucci-Cerinic, M.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Lidocaine controls pain and allows safe wound bed preparation and debridement of digital ulcers in systemic sclerosis: a retrospective study</title><author>Braschi, Francesca ; Bartoli, Francesca ; Bruni, Cosimo ; Fiori, Ginevra ; Fantauzzo, Claudia ; Paganelli, Lucia ; De Paulis, Amato ; Rasero, Laura ; Matucci-Cerinic, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-3b438efc2ac18372b3370900405a58fb579b43608d950ecbbd30c5862bea4c643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Anesthetics, Local - therapeutic use</topic><topic>Brief Report</topic><topic>Debridement - methods</topic><topic>Female</topic><topic>Fingers - pathology</topic><topic>Humans</topic><topic>Lidocaine - therapeutic use</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Pain - drug therapy</topic><topic>Pain Management</topic><topic>Pain Measurement</topic><topic>Retrospective Studies</topic><topic>Rheumatology</topic><topic>Scleroderma, Systemic - drug therapy</topic><topic>Scleroderma, Systemic - surgery</topic><topic>Skin Ulcer - therapy</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Braschi, Francesca</creatorcontrib><creatorcontrib>Bartoli, Francesca</creatorcontrib><creatorcontrib>Bruni, Cosimo</creatorcontrib><creatorcontrib>Fiori, Ginevra</creatorcontrib><creatorcontrib>Fantauzzo, Claudia</creatorcontrib><creatorcontrib>Paganelli, Lucia</creatorcontrib><creatorcontrib>De Paulis, Amato</creatorcontrib><creatorcontrib>Rasero, Laura</creatorcontrib><creatorcontrib>Matucci-Cerinic, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braschi, Francesca</au><au>Bartoli, Francesca</au><au>Bruni, Cosimo</au><au>Fiori, Ginevra</au><au>Fantauzzo, Claudia</au><au>Paganelli, Lucia</au><au>De Paulis, Amato</au><au>Rasero, Laura</au><au>Matucci-Cerinic, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lidocaine controls pain and allows safe wound bed preparation and debridement of digital ulcers in systemic sclerosis: a retrospective study</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2017</date><risdate>2017</risdate><volume>36</volume><issue>1</issue><spage>209</spage><epage>212</epage><pages>209-212</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>In Systemic Sclerosis (SSc), digital ulcers (DU) are painful, difficult to heal, and frequently infected. To reduce the risk of bacterial infection and to prevent chronicity, it is essential to carefully remove necrotic tissue from DU, with maximum patient comfort. Debridement, although very efficacious, is invasive and causes local pain: lidocaine is a local anesthetic commonly used as to fight pain during debridement procedures. The aim of the study was to evaluate the efficacy of lidocaine 4 % in pain control during debridement procedure of DU in SSc. One hundred eight DU characterized by pain Numeric Rating Scale (NRS) >3/10 before starting the procedure were treated with lidocaine 4 % (lidocaine cloridrate 200 mg in 5 ml of injecting solution). Pain was measured with NRS (0–10) before starting debridement, after 15 min of lidocaine application and at the end of the procedure. In DU, in respect to baseline (mean NRS 6.74 ± 2.96), pain after application of lidocaine 4 % for 15 min was significantly lower (mean NRS 2.83 ± 2.73) (
p
< 0.001). At the end of the procedure, pain control was still maintained and significantly lower (mean NRS 2.88 ± 2.65) in respect to baseline (
p
< 0.001). No systemic adverse event due to topical lidocaine were observed. In SSc, topical application of lidocaine 4 % significantly reduces pain, allowing a safe debridement procedure, thus improving the management of DU.</abstract><cop>London</cop><pub>Springer London</pub><pmid>27686661</pmid><doi>10.1007/s10067-016-3414-7</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Anesthetics, Local - therapeutic use Brief Report Debridement - methods Female Fingers - pathology Humans Lidocaine - therapeutic use Male Medicine Medicine & Public Health Middle Aged Pain - drug therapy Pain Management Pain Measurement Retrospective Studies Rheumatology Scleroderma, Systemic - drug therapy Scleroderma, Systemic - surgery Skin Ulcer - therapy Wound Healing |
| title | Lidocaine controls pain and allows safe wound bed preparation and debridement of digital ulcers in systemic sclerosis: a retrospective study |
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