Dietary fiber and the short‐chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice

Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints. Continuous gout episodes may lead to unresolved inflammatory responses and tissue damage. We investigated the effects of a high‐fiber diet and acetate, a short‐chain fatty acid (SCFA) resulting from t...

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Veröffentlicht in:	Journal of leukocyte biology 2017-01, Vol.101 (1), p.275-284
Hauptverfasser:	Vieira, Angélica T., Galvão, Izabela, Macia, Laurence M., Sernaglia, érica M., Vinolo, Marco Aurélio R., Garcia, Cristiana C., Tavares, Luciana P., Amaral, Flávio A., Sousa, Lirlândia P., Martins, Flaviano S., Mackay, Charles R., Teixeira, Mauro M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Acetic acid Animals Apoptosis Apoptosis - drug effects arthritis Caspase Caspases - metabolism Chains Crystallization Crystals Diet Diet, High-Fat Dietary fiber Dietary Fiber - pharmacology Disease Models, Animal Fatty acids Gout Gout - pathology immunoregulation Inflammation Inflammation - pathology Inflammation Mediators - metabolism Inflammatory response Injection Interleukin 10 Intestinal microflora Joint diseases Joints - drug effects Joints - pathology Knee Leukocytes (neutrophilic) Macrophages - drug effects Macrophages - metabolism Male Metabolism Mice Mice, Inbred C57BL Microbiota Neutrophils Neutrophils - pathology NF-kappa B - metabolism NF-κB protein Phagocytosis - drug effects Rheumatism Uric Acid
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