Microbial genome-wide association studies: lessons from human GWAS

Key Points Genome-wide association studies (GWAS) have been highly successful in the analyses of human genomic data. The increased availability of microorganism whole genomes provides the opportunity for microbial GWAS. Initial microbial GWAS have had success identifying variants for traits under st...

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Veröffentlicht in:	Nature reviews. Genetics 2017-01, Vol.18 (1), p.41-50
Hauptverfasser:	Power, Robert A., Parkhill, Julian, de Oliveira, Tulio
Format:	Artikel
Sprache:	eng
Schlagworte:	631/205/2138 631/326/325 Agriculture Animal Genetics and Genomics Bacteria Biomedicine Cancer Research Communicable Diseases - genetics Communicable Diseases - microbiology Development and progression Disease Drug resistance Gene Function Genetic aspects Genetic Predisposition to Disease Genetic susceptibility Genome, Human Genome, Microbial Genome-wide association studies Genome-Wide Association Study Genomes Genomics Genotype Genotype & phenotype Health risk assessment Human Genetics Humans Hypotheses Microbial drug resistance Microorganisms Physiological aspects Polygenic inheritance Polymorphism Quality control Regression analysis review-article Single nucleotide polymorphisms
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