Toll-like receptor 4 activation attenuates profibrotic response in control lung fibroblasts but not in fibroblasts from patients with IPF

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with a median survival of 3 yr. IPF deteriorates upon viral or bacterial lung infection although pulmonary infection (pneumonia) in healthy lungs rarely induces fibrosis. Bacterial lipopolysaccharide (LPS) activates Toll-like receptor...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2017-01, Vol.312 (1), p.L42-L55
Hauptverfasser:	Ebener, Simone, Barnowski, Sandra, Wotzkow, Carlos, Marti, Thomas M, Lopez-Rodriguez, Elena, Crestani, Bruno, Blank, Fabian, Schmid, Ralph A, Geiser, Thomas, Funke, Manuela
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Separation Cells, Cultured Connective Tissue Growth Factor - metabolism Dinoprostone - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Gram-negative bacteria Growth factors Humans Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - pathology Lipopolysaccharides - pharmacology Lung - pathology Lungs Mutation - genetics Physiology Pneumonia Protein expression Pulmonary fibrosis Receptor, Epidermal Growth Factor - metabolism Smad3 Protein - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Transforming Growth Factor beta - pharmacology
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