Endothelial dysfunction and vascular disease – a 30th anniversary update

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing factor (EDRF) is nitric oxide (NO) which activates soluble guanylyl cyclase in the vascular smooth muscle cells, with the productio...

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Veröffentlicht in:	Acta Physiologica 2017-01, Vol.219 (1), p.22-96
Hauptverfasser:	Vanhoutte, P. M., Shimokawa, H., Feletou, M., Tang, E. H. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Circulatory system Cyclic GMP - metabolism cyclic guanosine monophosphate cyclic inosine monophosphate Diabetes Endothelin-1 - metabolism endothelin‐1 Endothelium Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Humans hydrogen peroxide Hypertension Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiopathology Nitric oxide Nitric Oxide - metabolism Oxidative stress prostanoids Smooth muscle Vascular Diseases - metabolism Vascular Diseases - physiopathology Vasoconstriction - physiology Vasodilation - physiology Whooping cough
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