Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

Summary Background Until now, polymyxin resistance has involved chromosomal mutations but has never been reported via horizontal gene transfer. During a routine surveillance project on antimicrobial resistance in commensal Escherichia coli from food animals in China, a major increase of colistin res...

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Veröffentlicht in:	The Lancet infectious diseases 2016-02, Vol.16 (2), p.161-168
Hauptverfasser:	Liu, Yi-Yun, BS, Wang, Yang, PhD, Walsh, Timothy R, Prof, Yi, Ling-Xian, BS, Zhang, Rong, PhD, Spencer, James, PhD, Doi, Yohei, MD, Tian, Guobao, PhD, Dong, Baolei, BS, Huang, Xianhui, PhD, Yu, Lin-Feng, BS, Gu, Danxia, PhD, Ren, Hongwei, BS, Chen, Xiaojie, MS, Lv, Luchao, MS, He, Dandan, MS, Zhou, Hongwei, PhD, Liang, Zisen, Prof, Liu, Jian-Hua, Prof, Shen, Jianzhong, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animals Antibiotics Antimicrobial agents Bacteria Bacteriology China Colistin - therapeutic use Drug resistance Drug Resistance, Bacterial - immunology E coli Enterobacteriaceae Enterobacteriaceae - drug effects Enterobacteriaceae Infections - drug therapy Enterobacteriaceae Infections - immunology Escherichia coli Farms Food Gram-negative bacteria Hogs Humans Infectious Disease Infectious diseases Klebsiella pneumoniae Laboratory animals Lipids Mass spectrometry Meat - microbiology Mice Plasmids - immunology Polymyxins - therapeutic use Pseudomonas aeruginosa Surveillance Swine Swine Diseases - drug therapy Veterinary medicine
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