The RP105/MD‐1 complex: molecular signaling mechanisms and pathophysiological implications
Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll‐IL‐1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune‐mediated pathologies, including infection...
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| Veröffentlicht in: | Journal of leukocyte biology 2017-01, Vol.101 (1), p.183-192 |
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| creator | Schultz, Thomas E. Blumenthal, Antje |
| description | Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll‐IL‐1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune‐mediated pathologies, including infection, chronic inflammation, and autoimmune disorders. Radioprotective 105 kDa activates macrophages and B cells independently of canonical TLR signaling. Current understanding of the functional consequences of radioprotective 105 kDa signaling in B cells, macrophages, and dendritic cells indicates overlapping, but also some apparent opposing, cell‐specific roles for radioprotective 105 kDa in shaping cellular functions. This review compares interactions of radioprotective 105 kDa with its coreceptors, CD19, TLR4, and TLR2; integrates recent, novel findings on radioprotective 105 kDa‐mediated molecular signaling mechanisms; and summarizes current understanding of its contributions to infectious, inflammatory, and autoimmune disease.
Review of how molecular signaling events driven by RP105 (CD180) shape the function of B cells, macrophages, and DCs. |
| doi_str_mv | 10.1189/jlb.2VMR1215-582R |
| format | Article |
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Blumenthal, Antje</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5663-fb0083cc9b11056ff689eb616e9c11cc4d009f13125f4255c5b7d654a33c196f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antigens, CD - metabolism</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - physiopathology</topic><topic>autoimmunity</topic><topic>B cells</topic><topic>B-Lymphocytes - immunology</topic><topic>CD18 antigen</topic><topic>CD19 antigen</topic><topic>Chronic infection</topic><topic>Dendritic cells</topic><topic>Humans</topic><topic>infection</topic><topic>inflammation</topic><topic>Interleukin 1 receptors</topic><topic>Intracellular signalling</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphocytes B</topic><topic>Macrophages</topic><topic>Signal Transduction</topic><topic>TLR2 protein</topic><topic>TLR4 protein</topic><topic>Toll-like receptors</topic><topic>Toll-Like Receptors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schultz, Thomas E.</creatorcontrib><creatorcontrib>Blumenthal, Antje</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schultz, Thomas E.</au><au>Blumenthal, Antje</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The RP105/MD‐1 complex: molecular signaling mechanisms and pathophysiological implications</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>2017-01</date><risdate>2017</risdate><volume>101</volume><issue>1</issue><spage>183</spage><epage>192</epage><pages>183-192</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><abstract>Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll‐IL‐1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune‐mediated pathologies, including infection, chronic inflammation, and autoimmune disorders. Radioprotective 105 kDa activates macrophages and B cells independently of canonical TLR signaling. Current understanding of the functional consequences of radioprotective 105 kDa signaling in B cells, macrophages, and dendritic cells indicates overlapping, but also some apparent opposing, cell‐specific roles for radioprotective 105 kDa in shaping cellular functions. This review compares interactions of radioprotective 105 kDa with its coreceptors, CD19, TLR4, and TLR2; integrates recent, novel findings on radioprotective 105 kDa‐mediated molecular signaling mechanisms; and summarizes current understanding of its contributions to infectious, inflammatory, and autoimmune disease.
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Animals Antigens, CD - metabolism Autoimmune diseases Autoimmune Diseases - immunology Autoimmune Diseases - physiopathology autoimmunity B cells B-Lymphocytes - immunology CD18 antigen CD19 antigen Chronic infection Dendritic cells Humans infection inflammation Interleukin 1 receptors Intracellular signalling Lymphocyte Activation - immunology Lymphocytes B Macrophages Signal Transduction TLR2 protein TLR4 protein Toll-like receptors Toll-Like Receptors - metabolism |
| title | The RP105/MD‐1 complex: molecular signaling mechanisms and pathophysiological implications |
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