The intravenous and oral pharmacokinetics of afoxolaner and milbemycin oxime when used as a combination chewable parasiticide for dogs

The pharmacokinetics of afoxolaner and milbemycin oxime (A3 and A4 forms) in dogs were evaluated following the oral administration of NexGard Spectra® (Merial), a fixed combination chewable formulation of these two active pharmaceutical ingredients. Absorption of actives was rapid at levels that pro...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2017-01, Vol.40 (1), p.35-43
Hauptverfasser:	Letendre, L., Harriman, J., Drag, M., Mullins, A., Malinski, T., Rehbein, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acaricides - administration & dosage Acaricides - blood Acaricides - pharmacokinetics Acaricides - therapeutic use Administration, Intravenous - veterinary Administration, Oral Animals Biological Availability Dog Diseases - drug therapy Dog Diseases - parasitology Dogs Drug Combinations Female Flea Infestations - drug therapy Flea Infestations - veterinary Insecticides - administration & dosage Insecticides - blood Insecticides - pharmacokinetics Insecticides - therapeutic use Isoxazoles - administration & dosage Isoxazoles - blood Isoxazoles - pharmacokinetics Isoxazoles - therapeutic use Macrolides - administration & dosage Macrolides - blood Macrolides - pharmacokinetics Macrolides - therapeutic use Male Naphthalenes - administration & dosage Naphthalenes - blood Naphthalenes - pharmacokinetics Naphthalenes - therapeutic use Tick Infestations - drug therapy Tick Infestations - veterinary
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