EGFR gene copy number predicts response to anti‐EGFR treatment in RAS wild type and RAS/BRAF/PIK3CA wild type metastatic colorectal cancer

Anti‐EGFR antibodies are used for the treatment of RAS wild type metastatic colorectal cancer. We previously showed that EGFR gene copy number (GCN) predicts response to anti‐EGFR therapy in KRAS exon 2 wild type metastatic colorectal cancer. The aim of our study was to analyse the predictive role o...

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Veröffentlicht in:	International journal of cancer 2017-02, Vol.140 (4), p.922-929
Hauptverfasser:	Ålgars, Annika, Sundström, Jari, Lintunen, Minnamaija, Jokilehto, Terhi, Kytölä, Soili, Kaare, Milja, Vainionpää, Reetta, Orpana, Arto, Österlund, Pia, Ristimäki, Ari, Carpen, Olli, Ristamäki, Raija
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - secondary Adult Aged Aged, 80 and over Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use anti‐EGFR treatment BRAF Camptothecin - administration & dosage Camptothecin - analogs & derivatives Cancer Cetuximab - administration & dosage Cetuximab - pharmacology Cetuximab - therapeutic use Class I Phosphatidylinositol 3-Kinases Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Disease-Free Survival Drug Resistance, Neoplasm - genetics EGFR gene copy number Epidermal growth factor Female Fluorouracil - administration & dosage Follow-Up Studies Gene Dosage Genes Genes, ras High-Throughput Nucleotide Sequencing Humans Male Medical research Metastasis metastatic colorectal cancer Middle Aged Molecular Targeted Therapy Mutation Phosphatidylinositol 3-Kinases - genetics PIK3CA mutations Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins B-raf - genetics RAS Receptor, Epidermal Growth Factor Tumors
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