Recent trends in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes

MicroRNAs (miRNAs) are short non-coding RNAs that regulate the function of target genes at the post-transcriptional phase. miRNAs are considered to have roles in the development, progression and metastasis of cancer. Recent studies have indicated that particular miRNA signatures are correlated with...

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Veröffentlicht in:Journal of human genetics 2017-01, Vol.62 (1), p.15-24
Hauptverfasser: Kurozumi, Sasagu, Yamaguchi, Yuri, Kurosumi, Masafumi, Ohira, Miki, Matsumoto, Hiroshi, Horiguchi, Jun
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container_issue 1
container_start_page 15
container_title Journal of human genetics
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creator Kurozumi, Sasagu
Yamaguchi, Yuri
Kurosumi, Masafumi
Ohira, Miki
Matsumoto, Hiroshi
Horiguchi, Jun
description MicroRNAs (miRNAs) are short non-coding RNAs that regulate the function of target genes at the post-transcriptional phase. miRNAs are considered to have roles in the development, progression and metastasis of cancer. Recent studies have indicated that particular miRNA signatures are correlated with tumor aggressiveness, response to drug therapy and patient outcome in breast cancer. On the other hand, in routine clinical practice, the treatment regimens for breast cancer are determined based on the intrinsic subtype of the primary tumor. Previous studies have shown that miRNA expression profiles of each intrinsic subtypes of breast cancer differ. In hormone receptor-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer, miRNA expressions are found to be correlated with endocrine therapy resistance, progesterone receptor expression and heat shock protein activity. Some miRNAs are associated with resistance to HER2-targeted therapy and HER3 expression in HER2-positive breast cancer. In triple-negative breast cancer, miRNA expressions are found to be associated with BRCA mutations, immune system, epithelial-mesenchymal transition, cancer stem cell properties and androgen receptor expression. As it has been clarified that the expression levels and functions of miRNA differ among the various subtypes of breast cancer, and it is necessary to take account of the characteristics of each breast cancer subtype during research into the roles of miRNA in breast cancer. In addition, the discovery of the roles played by miRNAs in breast cancer might provide new opportunities for the development of novel strategies for diagnosing and treating breast cancer.
doi_str_mv 10.1038/jhg.2016.89
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subjects BRCA1 Protein - genetics
Breast Neoplasms - classification
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Female
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs - genetics
Mutation
Receptor, ErbB-2 - metabolism
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
title Recent trends in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes
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