The role of compliance with PAP use on blood pressure in patients with obstructive sleep apnea: is longer use a key-factor?
Scientific data about the effects of positive airway pressure (PAP) treatment on blood pressure (BP) control are continuously increasing; however, they are controversial. We aimed to determine the long-term effects of compliance with PAP therapy on BP in both hypertensive and normotensive patients w...
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| Veröffentlicht in: | Journal of human hypertension 2017-02, Vol.31 (2), p.106-115 |
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| creator | Bouloukaki, I Mermigkis, C Tzanakis, N Giannadaki, K Mauroudi, E Moniaki, V Kallergis, E M Schiza, S E |
| description | Scientific data about the effects of positive airway pressure (PAP) treatment on blood pressure (BP) control are continuously increasing; however, they are controversial. We aimed to determine the long-term effects of compliance with PAP therapy on BP in both hypertensive and normotensive patients with obstructive sleep apnea–hypopnea syndrome (OSAHS). One thousand one hundred sixty eight consecutive patients with newly diagnosed OSAHS, who had been recommended PAP therapy, were followed up for a minimum of 2 years. Patients with previous cardiovascular disease were excluded. BP was measured at baseline and after 2 years of PAP treatment. In addition, the correlation between the changes in BP with different levels of PAP compliance was assessed. At the end of the follow-up period, in the hypertensive group of patients (
n
=586), a significant decrease was shown in systolic (−11.2 mm Hg,
P |
| doi_str_mv | 10.1038/jhh.2016.47 |
| format | Article |
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n
=586), a significant decrease was shown in systolic (−11.2 mm Hg,
P
<0.001) and diastolic BP (−4.2 mm Hg,
P
<0.001). Furthermore, in the patients without hypertension (
n
=528), a significant decrease was noted both in systolic and diastolic BP (−3.6,
P
<0.001 and −2.4,
P
<0.001, respectively). A correlation between the magnitude of change in systolic and diastolic BP and hours of use of PAP (
r
=0.14,
P
=0.002 and
r
=0.1,
P
=0.025, respectively) was observed in all patients. Long-term use of PAP treatment, as well as increased hours of PAP in patients with OSAHS use showed significant reductions in BP not only in patients with hypertension, but also in normotensive patients. Therefore a significant potential reduction in cardiovascular mortality and morbidity should be expected in these patients.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/jhh.2016.47</identifier><identifier>PMID: 27465978</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/700/459 ; Adult ; Aged ; Apnea ; Blood Pressure ; Blood pressure regulation ; Cardiovascular diseases ; Care and treatment ; Complications and side effects ; Continuous positive airway pressure ; Diagnosis ; Epidemiology ; Female ; Follow-Up Studies ; Health Administration ; Humans ; Hypertension ; Hypertension - complications ; Long-term effects ; Male ; Management ; Medicine ; Medicine & Public Health ; Methods ; Middle Aged ; Morbidity ; original-article ; Patient compliance ; Patient Compliance - statistics & numerical data ; Patient outcomes ; Patients ; Positive-Pressure Respiration - utilization ; Public Health ; Regulation ; Risk factors ; Sleep ; Sleep apnea ; Sleep apnea syndromes ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - therapy ; Sleep disorders</subject><ispartof>Journal of human hypertension, 2017-02, Vol.31 (2), p.106-115</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature. 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2017</rights><rights>Macmillan Publishers Limited, part of Springer Nature. 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-ab2f377e14537a140a203d636243587c0d19a661351b5cbff20f2e00b46491673</citedby><cites>FETCH-LOGICAL-c611t-ab2f377e14537a140a203d636243587c0d19a661351b5cbff20f2e00b46491673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27465978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouloukaki, I</creatorcontrib><creatorcontrib>Mermigkis, C</creatorcontrib><creatorcontrib>Tzanakis, N</creatorcontrib><creatorcontrib>Giannadaki, K</creatorcontrib><creatorcontrib>Mauroudi, E</creatorcontrib><creatorcontrib>Moniaki, V</creatorcontrib><creatorcontrib>Kallergis, E M</creatorcontrib><creatorcontrib>Schiza, S E</creatorcontrib><title>The role of compliance with PAP use on blood pressure in patients with obstructive sleep apnea: is longer use a key-factor?</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Scientific data about the effects of positive airway pressure (PAP) treatment on blood pressure (BP) control are continuously increasing; however, they are controversial. We aimed to determine the long-term effects of compliance with PAP therapy on BP in both hypertensive and normotensive patients with obstructive sleep apnea–hypopnea syndrome (OSAHS). One thousand one hundred sixty eight consecutive patients with newly diagnosed OSAHS, who had been recommended PAP therapy, were followed up for a minimum of 2 years. Patients with previous cardiovascular disease were excluded. BP was measured at baseline and after 2 years of PAP treatment. In addition, the correlation between the changes in BP with different levels of PAP compliance was assessed. At the end of the follow-up period, in the hypertensive group of patients (
n
=586), a significant decrease was shown in systolic (−11.2 mm Hg,
P
<0.001) and diastolic BP (−4.2 mm Hg,
P
<0.001). Furthermore, in the patients without hypertension (
n
=528), a significant decrease was noted both in systolic and diastolic BP (−3.6,
P
<0.001 and −2.4,
P
<0.001, respectively). A correlation between the magnitude of change in systolic and diastolic BP and hours of use of PAP (
r
=0.14,
P
=0.002 and
r
=0.1,
P
=0.025, respectively) was observed in all patients. Long-term use of PAP treatment, as well as increased hours of PAP in patients with OSAHS use showed significant reductions in BP not only in patients with hypertension, but also in normotensive patients. Therefore a significant potential reduction in cardiovascular mortality and morbidity should be expected in these patients.</description><subject>692/700/459</subject><subject>Adult</subject><subject>Aged</subject><subject>Apnea</subject><subject>Blood Pressure</subject><subject>Blood pressure regulation</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Continuous positive airway pressure</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health Administration</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Long-term effects</subject><subject>Male</subject><subject>Management</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>original-article</subject><subject>Patient compliance</subject><subject>Patient Compliance - statistics & numerical data</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Positive-Pressure Respiration - utilization</subject><subject>Public Health</subject><subject>Regulation</subject><subject>Risk factors</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep apnea syndromes</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Sleep disorders</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkl1rFDEUhgdR7Fq98l4Cggg6a74z440sxS8o2It6HTLZM52ss8k0ySjFP--MW3UrZSm5COQ8eQ45eYviKcFLgln1ZtN1S4qJXHJ1r1gQrmQpBFX3iwWuBS5ryvFR8SilDcZzsXpYHFHFpahVtSh-nneAYugBhRbZsB16Z7wF9MPlDp2tztCYppJHTR_CGg0RUhojIOfRYLIDn9MODU3KcbTZfQeUeoABmcGDeYtcQn3wFxB_mwz6Bldla2wO8d3j4kFr-gRPrvfj4uuH9-cnn8rTLx8_n6xOSysJyaVpaMuUAsIFU4ZwbChma8kk5UxUyuI1qY2UhAnSCNu0LcUtBYwbLnlNpGLHxcudd4jhcoSU9dYlC31vPIQxaVKJmitO8V1QOgm5UnJCn_-HbsIY_fQQTSURgtFKHKSmtgILyoj4R12YHrTzbcjR2Lm1XsmqphWvVX2QEkwwrDifXctbqGmtYets8NC66fyG9k4X9ju82LvQgelzl0I_Zhd8umk-CO4bX-1AG0NKEVo9RLc18UoTrOeQ6ynkeg655vMnPbue6dhsYf2X_ZPqCXi9A9JUmrO3N_RbfL8ANlj-gA</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Bouloukaki, I</creator><creator>Mermigkis, C</creator><creator>Tzanakis, N</creator><creator>Giannadaki, K</creator><creator>Mauroudi, E</creator><creator>Moniaki, V</creator><creator>Kallergis, E M</creator><creator>Schiza, S E</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>The role of compliance with PAP use on blood pressure in patients with obstructive sleep apnea: is longer use a key-factor?</title><author>Bouloukaki, I ; Mermigkis, C ; Tzanakis, N ; Giannadaki, K ; Mauroudi, E ; Moniaki, V ; Kallergis, E M ; Schiza, S E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-ab2f377e14537a140a203d636243587c0d19a661351b5cbff20f2e00b46491673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>692/700/459</topic><topic>Adult</topic><topic>Aged</topic><topic>Apnea</topic><topic>Blood Pressure</topic><topic>Blood pressure regulation</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Continuous positive airway pressure</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health Administration</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Long-term effects</topic><topic>Male</topic><topic>Management</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>original-article</topic><topic>Patient compliance</topic><topic>Patient Compliance - statistics & numerical data</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Positive-Pressure Respiration - utilization</topic><topic>Public Health</topic><topic>Regulation</topic><topic>Risk factors</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep apnea syndromes</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Sleep disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouloukaki, I</creatorcontrib><creatorcontrib>Mermigkis, C</creatorcontrib><creatorcontrib>Tzanakis, N</creatorcontrib><creatorcontrib>Giannadaki, K</creatorcontrib><creatorcontrib>Mauroudi, E</creatorcontrib><creatorcontrib>Moniaki, V</creatorcontrib><creatorcontrib>Kallergis, E M</creatorcontrib><creatorcontrib>Schiza, S E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouloukaki, I</au><au>Mermigkis, C</au><au>Tzanakis, N</au><au>Giannadaki, K</au><au>Mauroudi, E</au><au>Moniaki, V</au><au>Kallergis, E M</au><au>Schiza, S E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of compliance with PAP use on blood pressure in patients with obstructive sleep apnea: is longer use a key-factor?</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>31</volume><issue>2</issue><spage>106</spage><epage>115</epage><pages>106-115</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Scientific data about the effects of positive airway pressure (PAP) treatment on blood pressure (BP) control are continuously increasing; however, they are controversial. We aimed to determine the long-term effects of compliance with PAP therapy on BP in both hypertensive and normotensive patients with obstructive sleep apnea–hypopnea syndrome (OSAHS). One thousand one hundred sixty eight consecutive patients with newly diagnosed OSAHS, who had been recommended PAP therapy, were followed up for a minimum of 2 years. Patients with previous cardiovascular disease were excluded. BP was measured at baseline and after 2 years of PAP treatment. In addition, the correlation between the changes in BP with different levels of PAP compliance was assessed. At the end of the follow-up period, in the hypertensive group of patients (
n
=586), a significant decrease was shown in systolic (−11.2 mm Hg,
P
<0.001) and diastolic BP (−4.2 mm Hg,
P
<0.001). Furthermore, in the patients without hypertension (
n
=528), a significant decrease was noted both in systolic and diastolic BP (−3.6,
P
<0.001 and −2.4,
P
<0.001, respectively). A correlation between the magnitude of change in systolic and diastolic BP and hours of use of PAP (
r
=0.14,
P
=0.002 and
r
=0.1,
P
=0.025, respectively) was observed in all patients. Long-term use of PAP treatment, as well as increased hours of PAP in patients with OSAHS use showed significant reductions in BP not only in patients with hypertension, but also in normotensive patients. Therefore a significant potential reduction in cardiovascular mortality and morbidity should be expected in these patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27465978</pmid><doi>10.1038/jhh.2016.47</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of human hypertension, 2017-02, Vol.31 (2), p.106-115 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 692/700/459 Adult Aged Apnea Blood Pressure Blood pressure regulation Cardiovascular diseases Care and treatment Complications and side effects Continuous positive airway pressure Diagnosis Epidemiology Female Follow-Up Studies Health Administration Humans Hypertension Hypertension - complications Long-term effects Male Management Medicine Medicine & Public Health Methods Middle Aged Morbidity original-article Patient compliance Patient Compliance - statistics & numerical data Patient outcomes Patients Positive-Pressure Respiration - utilization Public Health Regulation Risk factors Sleep Sleep apnea Sleep apnea syndromes Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - therapy Sleep disorders |
| title | The role of compliance with PAP use on blood pressure in patients with obstructive sleep apnea: is longer use a key-factor? |
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