Competing risks analysis of cause‐specific mortality in patients with oral squamous cell carcinoma
Background Survival studies on head and neck cancers are frequently reported with inadequate account for competing causes of death. Realistic descriptions and predictions of postdiagnosis mortality should be based on proper competing risks methodology. Methods Prognosis of patients with oral squamou...
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| Veröffentlicht in: | Head & neck 2017-01, Vol.39 (1), p.56-62 |
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| creator | Läärä, Esa Korpi, Jarkko T. Pitkänen, Hanna Alho, Olli‐Pekka Kantola, Saara |
| description | Background
Survival studies on head and neck cancers are frequently reported with inadequate account for competing causes of death. Realistic descriptions and predictions of postdiagnosis mortality should be based on proper competing risks methodology.
Methods
Prognosis of patients with oral squamous cell carcinoma (OSCC) in terms of mortality from OSCC and from other causes, respectively, was analyzed according to recent methodological recommendations using cumulative incidence functions and models for cause‐specific hazards and subdistribution hazards in 306 patients treated in a tertiary care center in Northern Finland.
Results
More coherent and informative descriptions and predictions of mortality by cause were obtained with state‐of‐the‐art statistical methods for competing risks than using the prevalent but questionable practice to graph “disease‐specific survival.”
Conclusion
From the patients' perspective, proper competing risks analysis offers more relevant prognostic scenarios than naïve analyses of “disease‐specific survival”; therefore, it should be used in prognostic studies of head and neck cancers. © 2016 Wiley Periodicals, Head Neck 39: 56–62, 2017 |
| doi_str_mv | 10.1002/hed.24536 |
| format | Article |
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Survival studies on head and neck cancers are frequently reported with inadequate account for competing causes of death. Realistic descriptions and predictions of postdiagnosis mortality should be based on proper competing risks methodology.
Methods
Prognosis of patients with oral squamous cell carcinoma (OSCC) in terms of mortality from OSCC and from other causes, respectively, was analyzed according to recent methodological recommendations using cumulative incidence functions and models for cause‐specific hazards and subdistribution hazards in 306 patients treated in a tertiary care center in Northern Finland.
Results
More coherent and informative descriptions and predictions of mortality by cause were obtained with state‐of‐the‐art statistical methods for competing risks than using the prevalent but questionable practice to graph “disease‐specific survival.”
Conclusion
From the patients' perspective, proper competing risks analysis offers more relevant prognostic scenarios than naïve analyses of “disease‐specific survival”; therefore, it should be used in prognostic studies of head and neck cancers. © 2016 Wiley Periodicals, Head Neck 39: 56–62, 2017</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.24536</identifier><identifier>PMID: 27437667</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - therapy ; cause‐specific mortality ; competing risks ; cumulative incidence ; Female ; Finland ; Humans ; Male ; Middle Aged ; Mouth Neoplasms - diagnosis ; Mouth Neoplasms - mortality ; Mouth Neoplasms - therapy ; Prognosis ; Retrospective Studies ; Risk Assessment ; survival ; Survival Analysis ; Survival Rate ; Young Adult</subject><ispartof>Head & neck, 2017-01, Vol.39 (1), p.56-62</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4216-a29f776a5b5782beb622518015644c898dab127a83edc9fbaa8fb70bb9129a823</citedby><cites>FETCH-LOGICAL-c4216-a29f776a5b5782beb622518015644c898dab127a83edc9fbaa8fb70bb9129a823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.24536$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.24536$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27437667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Läärä, Esa</creatorcontrib><creatorcontrib>Korpi, Jarkko T.</creatorcontrib><creatorcontrib>Pitkänen, Hanna</creatorcontrib><creatorcontrib>Alho, Olli‐Pekka</creatorcontrib><creatorcontrib>Kantola, Saara</creatorcontrib><title>Competing risks analysis of cause‐specific mortality in patients with oral squamous cell carcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Survival studies on head and neck cancers are frequently reported with inadequate account for competing causes of death. Realistic descriptions and predictions of postdiagnosis mortality should be based on proper competing risks methodology.
Methods
Prognosis of patients with oral squamous cell carcinoma (OSCC) in terms of mortality from OSCC and from other causes, respectively, was analyzed according to recent methodological recommendations using cumulative incidence functions and models for cause‐specific hazards and subdistribution hazards in 306 patients treated in a tertiary care center in Northern Finland.
Results
More coherent and informative descriptions and predictions of mortality by cause were obtained with state‐of‐the‐art statistical methods for competing risks than using the prevalent but questionable practice to graph “disease‐specific survival.”
Conclusion
From the patients' perspective, proper competing risks analysis offers more relevant prognostic scenarios than naïve analyses of “disease‐specific survival”; therefore, it should be used in prognostic studies of head and neck cancers. © 2016 Wiley Periodicals, Head Neck 39: 56–62, 2017</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>cause‐specific mortality</subject><subject>competing risks</subject><subject>cumulative incidence</subject><subject>Female</subject><subject>Finland</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - diagnosis</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - therapy</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>survival</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><subject>Young Adult</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0ctKxDAUBuAgiveFLyABN7qok1uTdinjFQQ3ui4nmVSjbVOTFpmdj-Az-iRmnHEjCK4Swpc_h_wIHVBySglhkyc7O2Ui53INbVNSqoxwodYXe8EzTpTYQjsxPhNCuBRsE20xJbiSUm2j2dS3vR1c94iDiy8RQwfNPLqIfY0NjNF-vn_E3hpXO4NbHwZo3DDHrsM9DM52Q8RvbnjCPkCD4-sIrR8jNrZp0vVgXOdb2EMbNTTR7q_WXfRweXE_vc5u765upme3mRGMygxYWSslIde5Kpi2WjKW04LQXAphirKYgaZMQcHtzJS1BihqrYjWJWUlFIzvouNlbh_862jjULUuLkaBzqapKlrkpVCUKvoPyqRitGQq0aNf9NmPIX3TQon0Nmc0T-pkqUzwMQZbV31wLYR5RUm1aKlKLVXfLSV7uEocdZtOf-RPLQlMluDNNXb-d1J1fXG-jPwCTu6cYA</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Läärä, Esa</creator><creator>Korpi, Jarkko T.</creator><creator>Pitkänen, Hanna</creator><creator>Alho, Olli‐Pekka</creator><creator>Kantola, Saara</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Competing risks analysis of cause‐specific mortality in patients with oral squamous cell carcinoma</title><author>Läärä, Esa ; Korpi, Jarkko T. ; Pitkänen, Hanna ; Alho, Olli‐Pekka ; Kantola, Saara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4216-a29f776a5b5782beb622518015644c898dab127a83edc9fbaa8fb70bb9129a823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>cause‐specific mortality</topic><topic>competing risks</topic><topic>cumulative incidence</topic><topic>Female</topic><topic>Finland</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - diagnosis</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - therapy</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>survival</topic><topic>Survival Analysis</topic><topic>Survival Rate</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Läärä, Esa</creatorcontrib><creatorcontrib>Korpi, Jarkko T.</creatorcontrib><creatorcontrib>Pitkänen, Hanna</creatorcontrib><creatorcontrib>Alho, Olli‐Pekka</creatorcontrib><creatorcontrib>Kantola, Saara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Läärä, Esa</au><au>Korpi, Jarkko T.</au><au>Pitkänen, Hanna</au><au>Alho, Olli‐Pekka</au><au>Kantola, Saara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Competing risks analysis of cause‐specific mortality in patients with oral squamous cell carcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2017-01</date><risdate>2017</risdate><volume>39</volume><issue>1</issue><spage>56</spage><epage>62</epage><pages>56-62</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Survival studies on head and neck cancers are frequently reported with inadequate account for competing causes of death. Realistic descriptions and predictions of postdiagnosis mortality should be based on proper competing risks methodology.
Methods
Prognosis of patients with oral squamous cell carcinoma (OSCC) in terms of mortality from OSCC and from other causes, respectively, was analyzed according to recent methodological recommendations using cumulative incidence functions and models for cause‐specific hazards and subdistribution hazards in 306 patients treated in a tertiary care center in Northern Finland.
Results
More coherent and informative descriptions and predictions of mortality by cause were obtained with state‐of‐the‐art statistical methods for competing risks than using the prevalent but questionable practice to graph “disease‐specific survival.”
Conclusion
From the patients' perspective, proper competing risks analysis offers more relevant prognostic scenarios than naïve analyses of “disease‐specific survival”; therefore, it should be used in prognostic studies of head and neck cancers. © 2016 Wiley Periodicals, Head Neck 39: 56–62, 2017</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27437667</pmid><doi>10.1002/hed.24536</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - therapy cause‐specific mortality competing risks cumulative incidence Female Finland Humans Male Middle Aged Mouth Neoplasms - diagnosis Mouth Neoplasms - mortality Mouth Neoplasms - therapy Prognosis Retrospective Studies Risk Assessment survival Survival Analysis Survival Rate Young Adult |
| title | Competing risks analysis of cause‐specific mortality in patients with oral squamous cell carcinoma |
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