The moderating effects of sex on insula subdivision structure in youth with posttraumatic stress symptoms
Background The insula is involved in interoceptive processing, emotion awareness, and attention to salient stimuli. Research suggests that these functions are specific—albeit overlapping—within insula subdivisions. Additional studies also imply that sexual dimorphism and different rates of developme...
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| Veröffentlicht in: | Depression and anxiety 2017-01, Vol.34 (1), p.51-58 |
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| container_title | Depression and anxiety |
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| creator | Klabunde, Megan Weems, Carl F. Raman, Mira Carrion, Victor G. |
| description | Background
The insula is involved in interoceptive processing, emotion awareness, and attention to salient stimuli. Research suggests that these functions are specific—albeit overlapping—within insula subdivisions. Additional studies also imply that sexual dimorphism and different rates of development occur within these subdivisions in youth. The purpose of this study was to examine potential insula subdivision structure differences in youth with PTSD symptoms as compared to controls and test sex as a moderator of these differences.
Methods
Insula structure (volume, surface area, and thickness) was measured with structural magnetic resonance imaging (sMRI) and calculated using Freesurfer software. We compared insula structure across age‐ and sex‐matched boys and girls with (30 with and 29 without) PTSD symptoms while also controlling for age and whole brain measurements.
Results
Differences were specific to the insula's anterior circular sulcus. Within this subregion, boys with PTSD symptoms demonstrated larger volume and surface area than control boys, while girls with PTSD symptoms demonstrated smaller volume and surface area than control girls.
Discussion
Findings indicate a potential neurobiological explanation for sex differences in youth with PTSD symptoms. |
| doi_str_mv | 10.1002/da.22577 |
| format | Article |
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The insula is involved in interoceptive processing, emotion awareness, and attention to salient stimuli. Research suggests that these functions are specific—albeit overlapping—within insula subdivisions. Additional studies also imply that sexual dimorphism and different rates of development occur within these subdivisions in youth. The purpose of this study was to examine potential insula subdivision structure differences in youth with PTSD symptoms as compared to controls and test sex as a moderator of these differences.
Methods
Insula structure (volume, surface area, and thickness) was measured with structural magnetic resonance imaging (sMRI) and calculated using Freesurfer software. We compared insula structure across age‐ and sex‐matched boys and girls with (30 with and 29 without) PTSD symptoms while also controlling for age and whole brain measurements.
Results
Differences were specific to the insula's anterior circular sulcus. Within this subregion, boys with PTSD symptoms demonstrated larger volume and surface area than control boys, while girls with PTSD symptoms demonstrated smaller volume and surface area than control girls.
Discussion
Findings indicate a potential neurobiological explanation for sex differences in youth with PTSD symptoms.</description><identifier>ISSN: 1091-4269</identifier><identifier>EISSN: 1520-6394</identifier><identifier>DOI: 10.1002/da.22577</identifier><identifier>PMID: 27862643</identifier><language>eng</language><publisher>United States: Hindawi Limited</publisher><subject>Adolescent ; adolescents ; Assaults ; Cerebral Cortex - anatomy & histology ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - pathology ; Child ; children ; Children & youth ; Female ; Females ; Girls ; Humans ; insula ; Magnetic Resonance Imaging ; Male ; sex differences ; Sex Factors ; Stress Disorders, Post-Traumatic - diagnostic imaging ; Stress Disorders, Post-Traumatic - pathology ; traumatic stress</subject><ispartof>Depression and anxiety, 2017-01, Vol.34 (1), p.51-58</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><rights>2017 Wiley Periodicals, Inc., a Wiley company</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4167-bc6f21434563f923e43d693acf6a8f678dd5c05031f12bf5d4146330b97b42b73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fda.22577$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fda.22577$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27862643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klabunde, Megan</creatorcontrib><creatorcontrib>Weems, Carl F.</creatorcontrib><creatorcontrib>Raman, Mira</creatorcontrib><creatorcontrib>Carrion, Victor G.</creatorcontrib><title>The moderating effects of sex on insula subdivision structure in youth with posttraumatic stress symptoms</title><title>Depression and anxiety</title><addtitle>Depress Anxiety</addtitle><description>Background
The insula is involved in interoceptive processing, emotion awareness, and attention to salient stimuli. Research suggests that these functions are specific—albeit overlapping—within insula subdivisions. Additional studies also imply that sexual dimorphism and different rates of development occur within these subdivisions in youth. The purpose of this study was to examine potential insula subdivision structure differences in youth with PTSD symptoms as compared to controls and test sex as a moderator of these differences.
Methods
Insula structure (volume, surface area, and thickness) was measured with structural magnetic resonance imaging (sMRI) and calculated using Freesurfer software. We compared insula structure across age‐ and sex‐matched boys and girls with (30 with and 29 without) PTSD symptoms while also controlling for age and whole brain measurements.
Results
Differences were specific to the insula's anterior circular sulcus. Within this subregion, boys with PTSD symptoms demonstrated larger volume and surface area than control boys, while girls with PTSD symptoms demonstrated smaller volume and surface area than control girls.
Discussion
Findings indicate a potential neurobiological explanation for sex differences in youth with PTSD symptoms.</description><subject>Adolescent</subject><subject>adolescents</subject><subject>Assaults</subject><subject>Cerebral Cortex - anatomy & histology</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - pathology</subject><subject>Child</subject><subject>children</subject><subject>Children & youth</subject><subject>Female</subject><subject>Females</subject><subject>Girls</subject><subject>Humans</subject><subject>insula</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>sex differences</subject><subject>Sex Factors</subject><subject>Stress Disorders, Post-Traumatic - diagnostic imaging</subject><subject>Stress Disorders, Post-Traumatic - pathology</subject><subject>traumatic stress</subject><issn>1091-4269</issn><issn>1520-6394</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtP3TAQha2qqMClEr8AWeqmm4Bf8WOJoNBKSGwu68iJ7WKUxLcZu3D_fX15LbpiM2c08-lIMwehY0pOKSHszNlTxlqlPqED2jLSSG7E59oTQxvBpNlHhwAPhBBtNPmC9pnSkknBD1Bc33s8JecXm-P8G_sQ_JABp4DBP-E04zhDGS2G0rv4N0KsI8hLGXJZfF3ibSr5Hj_GWjYJcl5smarXsKM8AIbttMlpgiO0F-wI_uurrtDd1Y_1xc_m5vb618X5TTMIKlXTDzIwKrhoJQ-GcS-4k4bbIUirg1TauXYgLeE0UNaH1gkqJOekN6oXrFd8hb6_-G6W9Kd4yN0UYfDjaGefCnRUt0ZIo7T-ACqoMspoU9Fv_6EPqSxzPWRnKFtV_8kqdfJKlX7yrtsscbLLtnv7dwWaF-Axjn77vqek2-XYOds959hdnj8r_wevsY7L</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Klabunde, Megan</creator><creator>Weems, Carl F.</creator><creator>Raman, Mira</creator><creator>Carrion, Victor G.</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>The moderating effects of sex on insula subdivision structure in youth with posttraumatic stress symptoms</title><author>Klabunde, Megan ; Weems, Carl F. ; Raman, Mira ; Carrion, Victor G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4167-bc6f21434563f923e43d693acf6a8f678dd5c05031f12bf5d4146330b97b42b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>adolescents</topic><topic>Assaults</topic><topic>Cerebral Cortex - anatomy & histology</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Cortex - pathology</topic><topic>Child</topic><topic>children</topic><topic>Children & youth</topic><topic>Female</topic><topic>Females</topic><topic>Girls</topic><topic>Humans</topic><topic>insula</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>sex differences</topic><topic>Sex Factors</topic><topic>Stress Disorders, Post-Traumatic - diagnostic imaging</topic><topic>Stress Disorders, Post-Traumatic - pathology</topic><topic>traumatic stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klabunde, Megan</creatorcontrib><creatorcontrib>Weems, Carl F.</creatorcontrib><creatorcontrib>Raman, Mira</creatorcontrib><creatorcontrib>Carrion, Victor G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Depression and anxiety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klabunde, Megan</au><au>Weems, Carl F.</au><au>Raman, Mira</au><au>Carrion, Victor G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The moderating effects of sex on insula subdivision structure in youth with posttraumatic stress symptoms</atitle><jtitle>Depression and anxiety</jtitle><addtitle>Depress Anxiety</addtitle><date>2017-01</date><risdate>2017</risdate><volume>34</volume><issue>1</issue><spage>51</spage><epage>58</epage><pages>51-58</pages><issn>1091-4269</issn><eissn>1520-6394</eissn><abstract>Background
The insula is involved in interoceptive processing, emotion awareness, and attention to salient stimuli. Research suggests that these functions are specific—albeit overlapping—within insula subdivisions. Additional studies also imply that sexual dimorphism and different rates of development occur within these subdivisions in youth. The purpose of this study was to examine potential insula subdivision structure differences in youth with PTSD symptoms as compared to controls and test sex as a moderator of these differences.
Methods
Insula structure (volume, surface area, and thickness) was measured with structural magnetic resonance imaging (sMRI) and calculated using Freesurfer software. We compared insula structure across age‐ and sex‐matched boys and girls with (30 with and 29 without) PTSD symptoms while also controlling for age and whole brain measurements.
Results
Differences were specific to the insula's anterior circular sulcus. Within this subregion, boys with PTSD symptoms demonstrated larger volume and surface area than control boys, while girls with PTSD symptoms demonstrated smaller volume and surface area than control girls.
Discussion
Findings indicate a potential neurobiological explanation for sex differences in youth with PTSD symptoms.</abstract><cop>United States</cop><pub>Hindawi Limited</pub><pmid>27862643</pmid><doi>10.1002/da.22577</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent adolescents Assaults Cerebral Cortex - anatomy & histology Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Child children Children & youth Female Females Girls Humans insula Magnetic Resonance Imaging Male sex differences Sex Factors Stress Disorders, Post-Traumatic - diagnostic imaging Stress Disorders, Post-Traumatic - pathology traumatic stress |
| title | The moderating effects of sex on insula subdivision structure in youth with posttraumatic stress symptoms |
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