Dietary regulation of serine proteinases that are resistant to serine proteinase inhibitors
Ingestion of Kunitz soybean trypsin inhibitor (STI) by larval Helicoverpa zea, Agrotis ipsilon, and Trichoplusia ni extended the retention time of food in the digestive tract and increased the level of activity of proteolytic enzymes that were not susceptible to inhibition by STI. The level of enhan...
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| Veröffentlicht in: | Journal of insect physiology 1997-09, Vol.43 (9), p.855-874 |
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| container_title | Journal of insect physiology |
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| creator | Broadway, Roxanne M |
| description | Ingestion of Kunitz soybean trypsin inhibitor (STI) by larval
Helicoverpa zea,
Agrotis ipsilon, and
Trichoplusia ni extended the retention time of food in the digestive tract and increased the level of activity of proteolytic enzymes that were not susceptible to inhibition by STI. The level of enhancement of activity of STI-resistant (STI-R) enzyme(s) was directly influenced by the dosage and timing of exposure to STI. However, not all proteinase inhibitors (PIs) enhanced the level of proteinase inhibitor resistant (PI-R) enzymes, even if those PIs inhibited a significant proportion of enzyme activity. These findings suggest that a complex system may be responsible for the regulation of proteolytic enzymes in the midgut of larval Lepidoptera, and one hypothesis for this regulation is proposed. |
| doi_str_mv | 10.1016/S0022-1910(97)00028-0 |
| format | Article |
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Helicoverpa zea,
Agrotis ipsilon, and
Trichoplusia ni extended the retention time of food in the digestive tract and increased the level of activity of proteolytic enzymes that were not susceptible to inhibition by STI. The level of enhancement of activity of STI-resistant (STI-R) enzyme(s) was directly influenced by the dosage and timing of exposure to STI. However, not all proteinase inhibitors (PIs) enhanced the level of proteinase inhibitor resistant (PI-R) enzymes, even if those PIs inhibited a significant proportion of enzyme activity. These findings suggest that a complex system may be responsible for the regulation of proteolytic enzymes in the midgut of larval Lepidoptera, and one hypothesis for this regulation is proposed.</description><identifier>ISSN: 0022-1910</identifier><identifier>EISSN: 1879-1611</identifier><identifier>DOI: 10.1016/S0022-1910(97)00028-0</identifier><identifier>PMID: 12770497</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Agrotis ipsilon ; artificial diets ; Brassica oleracea var. capitata ; cabbage ; dietary protein ; dosage ; enzyme activity ; enzyme regulation ; Helicoverpa zea ; inhibition ; inhibitor resistant enzymes ; Kunitz soybean trypsin inhibitor ; lima bean trypsin inhibitor ; midgut ; ovomucoid ; pest resistance ; regulation ; resistance ; serine proteinases ; transit time ; Trichoplusia ni ; trypsin ; trypsin inhibitors</subject><ispartof>Journal of insect physiology, 1997-09, Vol.43 (9), p.855-874</ispartof><rights>1997 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-c485ed6c00405ebde0cb3a846271f93fc65acbd48b14384d49f4efd62f93ec1e3</citedby><cites>FETCH-LOGICAL-c465t-c485ed6c00405ebde0cb3a846271f93fc65acbd48b14384d49f4efd62f93ec1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-1910(97)00028-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12770497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Broadway, Roxanne M</creatorcontrib><title>Dietary regulation of serine proteinases that are resistant to serine proteinase inhibitors</title><title>Journal of insect physiology</title><addtitle>J Insect Physiol</addtitle><description>Ingestion of Kunitz soybean trypsin inhibitor (STI) by larval
Helicoverpa zea,
Agrotis ipsilon, and
Trichoplusia ni extended the retention time of food in the digestive tract and increased the level of activity of proteolytic enzymes that were not susceptible to inhibition by STI. The level of enhancement of activity of STI-resistant (STI-R) enzyme(s) was directly influenced by the dosage and timing of exposure to STI. However, not all proteinase inhibitors (PIs) enhanced the level of proteinase inhibitor resistant (PI-R) enzymes, even if those PIs inhibited a significant proportion of enzyme activity. These findings suggest that a complex system may be responsible for the regulation of proteolytic enzymes in the midgut of larval Lepidoptera, and one hypothesis for this regulation is proposed.</description><subject>Agrotis ipsilon</subject><subject>artificial diets</subject><subject>Brassica oleracea var. capitata</subject><subject>cabbage</subject><subject>dietary protein</subject><subject>dosage</subject><subject>enzyme activity</subject><subject>enzyme regulation</subject><subject>Helicoverpa zea</subject><subject>inhibition</subject><subject>inhibitor resistant enzymes</subject><subject>Kunitz soybean trypsin inhibitor</subject><subject>lima bean trypsin inhibitor</subject><subject>midgut</subject><subject>ovomucoid</subject><subject>pest resistance</subject><subject>regulation</subject><subject>resistance</subject><subject>serine proteinases</subject><subject>transit time</subject><subject>Trichoplusia ni</subject><subject>trypsin</subject><subject>trypsin inhibitors</subject><issn>0022-1910</issn><issn>1879-1611</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqF0cFOGzEQBmALtWpC6CNQ9lTRw8KM1-v1nlAFLVRC4pDm1IPl9c6Cq2QNtlOJt8chERyQ6MWW5c-e0T-MHSKcIKA8nQNwXmKLcNw23yCfVAl7bIqqaUuUiB_Y9IVM2H6MfzOqpao_sQnypgHRNlP258JRMuGxCHS7Xprk_Fj4oYgU3EjFffCJ3GgixSLdmVSYQFlGF5MZU5H8W1i48c51LvkQD9jHwSwjfd7tM7b4-eP3-VV5fXP56_z7dWmFrFNeVU29tAACaup6AttVRgnJGxzaarCyNrbrhepQVEr0oh0EDb3k-ZIsUjVjx9t_cxcPa4pJr1y0tFyakfw6alR1K0BgBZl-fZ9KwTEXybDeQht8jIEGfR_cKgelEfRmAPp5AHqTrm4b_TwAvSnwZVdg3a2of321SzyDoy0YjNfmNrioF3MOuTmuFFSCZ3G2FZQz--co6GgdjZZ6F8gm3Xv3nyaeAFivn9A</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Broadway, Roxanne M</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>19970901</creationdate><title>Dietary regulation of serine proteinases that are resistant to serine proteinase inhibitors</title><author>Broadway, Roxanne M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-c485ed6c00405ebde0cb3a846271f93fc65acbd48b14384d49f4efd62f93ec1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Agrotis ipsilon</topic><topic>artificial diets</topic><topic>Brassica oleracea var. capitata</topic><topic>cabbage</topic><topic>dietary protein</topic><topic>dosage</topic><topic>enzyme activity</topic><topic>enzyme regulation</topic><topic>Helicoverpa zea</topic><topic>inhibition</topic><topic>inhibitor resistant enzymes</topic><topic>Kunitz soybean trypsin inhibitor</topic><topic>lima bean trypsin inhibitor</topic><topic>midgut</topic><topic>ovomucoid</topic><topic>pest resistance</topic><topic>regulation</topic><topic>resistance</topic><topic>serine proteinases</topic><topic>transit time</topic><topic>Trichoplusia ni</topic><topic>trypsin</topic><topic>trypsin inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Broadway, Roxanne M</creatorcontrib><collection>AGRIS</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of insect physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Broadway, Roxanne M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary regulation of serine proteinases that are resistant to serine proteinase inhibitors</atitle><jtitle>Journal of insect physiology</jtitle><addtitle>J Insect Physiol</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>43</volume><issue>9</issue><spage>855</spage><epage>874</epage><pages>855-874</pages><issn>0022-1910</issn><eissn>1879-1611</eissn><abstract>Ingestion of Kunitz soybean trypsin inhibitor (STI) by larval
Helicoverpa zea,
Agrotis ipsilon, and
Trichoplusia ni extended the retention time of food in the digestive tract and increased the level of activity of proteolytic enzymes that were not susceptible to inhibition by STI. The level of enhancement of activity of STI-resistant (STI-R) enzyme(s) was directly influenced by the dosage and timing of exposure to STI. However, not all proteinase inhibitors (PIs) enhanced the level of proteinase inhibitor resistant (PI-R) enzymes, even if those PIs inhibited a significant proportion of enzyme activity. These findings suggest that a complex system may be responsible for the regulation of proteolytic enzymes in the midgut of larval Lepidoptera, and one hypothesis for this regulation is proposed.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>12770497</pmid><doi>10.1016/S0022-1910(97)00028-0</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of insect physiology, 1997-09, Vol.43 (9), p.855-874 |
| issn | 0022-1910 1879-1611 |
| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Agrotis ipsilon artificial diets Brassica oleracea var. capitata cabbage dietary protein dosage enzyme activity enzyme regulation Helicoverpa zea inhibition inhibitor resistant enzymes Kunitz soybean trypsin inhibitor lima bean trypsin inhibitor midgut ovomucoid pest resistance regulation resistance serine proteinases transit time Trichoplusia ni trypsin trypsin inhibitors |
| title | Dietary regulation of serine proteinases that are resistant to serine proteinase inhibitors |
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