Simple Designs for the Construction of Complex Trans-Fused Polyether Toxin Frameworks. A Convergent Strategy Based on Hydroxy Ketone Cyclization of C-Linked Oxacycles

A single, unified convergent strategy for the stereocontrolled synthesis of trans-fused polyethers was developed. It was demonstrated that the epimerization and reductive intramolecular coupling of hydroxy ketones in reactions with silane−Lewis acids (SI−LA) to generate ethers in C-linked oxacycles...

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Veröffentlicht in:	Journal of organic chemistry 1996-05, Vol.61 (9), p.3003-3016
Hauptverfasser:	Alvarez, Eleuterio, Pérez, Ricardo, Rico, Milagros, Rodríguez, Rosa M, Martín, Julio D
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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