Influence of TT virus infection on the thrombocytopenia of patients with chronic liver disease
TT virus (TTV) can replicate not only in the liver but also in hematopoietic cells. To investigate the possible influence of TTV infection on the hematological parameters of patients with chronic liver disease, serum samples from 581 patients with chronic, viral or non-viral liver disease were teste...
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| Veröffentlicht in: | Hepatology research 2001-07, Vol.20 (3), p.288-300 |
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| creator | Tokita, Hajime Murai, Seiyou Kamitsukasa, Hiroshi Yagura, Michiyasu Harada, Hideharu Takahashi, Masaharu Okamoto, Hiroaki |
| description | TT virus (TTV) can replicate not only in the liver but also in hematopoietic cells. To investigate the possible influence of TTV infection on the hematological parameters of patients with chronic liver disease, serum samples from 581 patients with chronic, viral or non-viral liver disease were tested for TTV DNA by polymerase chain reaction (PCR). PCR was performed by two distinct methods using N22 primer pairs (N22 PCR), which detect primarily the four major TTV genotypes (1–4), and using genotype 1-specific primers (Genotype 1-PCR). Thirteen hematological parameters measured in routine laboratory tests were compared among the patients who were positive or negative for TTV infection. The platelet count was significantly lower in the N22 PCR-positive group than in the N22 PCR-negative group among the 189 patients with chronic hepatitis C (CH-C) and among the 40 patients with chronic hepatitis without serological markers of ongoing hepatitis B virus or hepatitis C virus infection (CH-NBNC) (
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| doi_str_mv | 10.1016/S1386-6346(00)00146-7 |
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P<0.0001,
P<0.005, respectively). Similarly, among the patients with CH-C or CH-NBNC, the platelet count was significantly lower in the TTV genotype 1-positive group than in the TTV genotype 1-negative group (
P<0.001,
P<0.05, respectively). The reduced platelet count of the TTV DNA-positive group was observed in every fibrotic stage of chronic hepatitis (F0–F3). These results suggest that infection of TTV of certain genotypes including genotype 1 may worsen the thrombocytopenia of patients with CH-C or CH-NBNC, irrespective of the degree of hepatic fibrosis.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1016/S1386-6346(00)00146-7</identifier><identifier>PMID: 11404189</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Chronic liver disease ; Hematological parameters ; Human viral diseases ; Infectious diseases ; Medical sciences ; Platelet count ; TT virus (TTV) ; Viral diseases ; Viral hepatitis</subject><ispartof>Hepatology research, 2001-07, Vol.20 (3), p.288-300</ispartof><rights>2001 Elsevier Science B.V.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-ae3e2298658e6441ee03938f6bcf2d0da46e1a7445b96a3a182c0756d2dc5b703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1027878$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11404189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tokita, Hajime</creatorcontrib><creatorcontrib>Murai, Seiyou</creatorcontrib><creatorcontrib>Kamitsukasa, Hiroshi</creatorcontrib><creatorcontrib>Yagura, Michiyasu</creatorcontrib><creatorcontrib>Harada, Hideharu</creatorcontrib><creatorcontrib>Takahashi, Masaharu</creatorcontrib><creatorcontrib>Okamoto, Hiroaki</creatorcontrib><title>Influence of TT virus infection on the thrombocytopenia of patients with chronic liver disease</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>TT virus (TTV) can replicate not only in the liver but also in hematopoietic cells. To investigate the possible influence of TTV infection on the hematological parameters of patients with chronic liver disease, serum samples from 581 patients with chronic, viral or non-viral liver disease were tested for TTV DNA by polymerase chain reaction (PCR). PCR was performed by two distinct methods using N22 primer pairs (N22 PCR), which detect primarily the four major TTV genotypes (1–4), and using genotype 1-specific primers (Genotype 1-PCR). Thirteen hematological parameters measured in routine laboratory tests were compared among the patients who were positive or negative for TTV infection. The platelet count was significantly lower in the N22 PCR-positive group than in the N22 PCR-negative group among the 189 patients with chronic hepatitis C (CH-C) and among the 40 patients with chronic hepatitis without serological markers of ongoing hepatitis B virus or hepatitis C virus infection (CH-NBNC) (
P<0.0001,
P<0.005, respectively). Similarly, among the patients with CH-C or CH-NBNC, the platelet count was significantly lower in the TTV genotype 1-positive group than in the TTV genotype 1-negative group (
P<0.001,
P<0.05, respectively). The reduced platelet count of the TTV DNA-positive group was observed in every fibrotic stage of chronic hepatitis (F0–F3). These results suggest that infection of TTV of certain genotypes including genotype 1 may worsen the thrombocytopenia of patients with CH-C or CH-NBNC, irrespective of the degree of hepatic fibrosis.</description><subject>Biological and medical sciences</subject><subject>Chronic liver disease</subject><subject>Hematological parameters</subject><subject>Human viral diseases</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Platelet count</subject><subject>TT virus (TTV)</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkU1PxCAQhonR-P0TNBw86KEKhQI9GWP8Skw8uCaeJJROI6YLK7Rr_Pey7hq9mUCYw_POTB4QOqDklBIqzh4pU6IQjItjQk4IoVwUcg1tUyXLgjD-vJ7rH2QL7aT0liFJSr6JtijlhFNVb6OXO9_1I3gLOHR4MsFzF8eEne_ADi54nM_wCvnGMG2C_RzCDLwzC3pmBgd-SPjDDa_YZsI7i3s3h4hbl8Ak2EMbnekT7K_eXfR0fTW5vC3uH27uLi_uC8t5NRQGGJRlrUSlQHBOAQirmepEY7uyJa3hAqiRmW1qYZihqrREVqItW1s1krBddLzsO4vhfYQ06KlLFvreeAhj0lRVNas4E3VGqyVqY0gpQqdn0U1N_NSU6IVa_a1WL7xpQvS3Wi1z7nA1Ymym0P6mVi4zcLQCTLKm76Lx1qU_3UuppMrY-RKD7GPuIOpk3eIDWhezc90G988mX6M_lb0</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Tokita, Hajime</creator><creator>Murai, Seiyou</creator><creator>Kamitsukasa, Hiroshi</creator><creator>Yagura, Michiyasu</creator><creator>Harada, Hideharu</creator><creator>Takahashi, Masaharu</creator><creator>Okamoto, Hiroaki</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>Influence of TT virus infection on the thrombocytopenia of patients with chronic liver disease</title><author>Tokita, Hajime ; Murai, Seiyou ; Kamitsukasa, Hiroshi ; Yagura, Michiyasu ; Harada, Hideharu ; Takahashi, Masaharu ; Okamoto, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-ae3e2298658e6441ee03938f6bcf2d0da46e1a7445b96a3a182c0756d2dc5b703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Chronic liver disease</topic><topic>Hematological parameters</topic><topic>Human viral diseases</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Platelet count</topic><topic>TT virus (TTV)</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tokita, Hajime</creatorcontrib><creatorcontrib>Murai, Seiyou</creatorcontrib><creatorcontrib>Kamitsukasa, Hiroshi</creatorcontrib><creatorcontrib>Yagura, Michiyasu</creatorcontrib><creatorcontrib>Harada, Hideharu</creatorcontrib><creatorcontrib>Takahashi, Masaharu</creatorcontrib><creatorcontrib>Okamoto, Hiroaki</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tokita, Hajime</au><au>Murai, Seiyou</au><au>Kamitsukasa, Hiroshi</au><au>Yagura, Michiyasu</au><au>Harada, Hideharu</au><au>Takahashi, Masaharu</au><au>Okamoto, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of TT virus infection on the thrombocytopenia of patients with chronic liver disease</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>20</volume><issue>3</issue><spage>288</spage><epage>300</epage><pages>288-300</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>TT virus (TTV) can replicate not only in the liver but also in hematopoietic cells. To investigate the possible influence of TTV infection on the hematological parameters of patients with chronic liver disease, serum samples from 581 patients with chronic, viral or non-viral liver disease were tested for TTV DNA by polymerase chain reaction (PCR). PCR was performed by two distinct methods using N22 primer pairs (N22 PCR), which detect primarily the four major TTV genotypes (1–4), and using genotype 1-specific primers (Genotype 1-PCR). Thirteen hematological parameters measured in routine laboratory tests were compared among the patients who were positive or negative for TTV infection. The platelet count was significantly lower in the N22 PCR-positive group than in the N22 PCR-negative group among the 189 patients with chronic hepatitis C (CH-C) and among the 40 patients with chronic hepatitis without serological markers of ongoing hepatitis B virus or hepatitis C virus infection (CH-NBNC) (
P<0.0001,
P<0.005, respectively). Similarly, among the patients with CH-C or CH-NBNC, the platelet count was significantly lower in the TTV genotype 1-positive group than in the TTV genotype 1-negative group (
P<0.001,
P<0.05, respectively). The reduced platelet count of the TTV DNA-positive group was observed in every fibrotic stage of chronic hepatitis (F0–F3). These results suggest that infection of TTV of certain genotypes including genotype 1 may worsen the thrombocytopenia of patients with CH-C or CH-NBNC, irrespective of the degree of hepatic fibrosis.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>11404189</pmid><doi>10.1016/S1386-6346(00)00146-7</doi><tpages>13</tpages></addata></record> |
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| subjects | Biological and medical sciences Chronic liver disease Hematological parameters Human viral diseases Infectious diseases Medical sciences Platelet count TT virus (TTV) Viral diseases Viral hepatitis |
| title | Influence of TT virus infection on the thrombocytopenia of patients with chronic liver disease |
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