Biliary excretion of temocapril in zone 1- and zone 3-injured rat

Temocapril is a prodrug of an angiotensin-converting enzyme inhibitor, temocaprilat, a substrate of multidrug resistance protein 2. Hepatocytes in zone 1 play a role in the uptake and biliary excretion of bile acids under physiological condition, and those in zone 3 may play a role only with their h...

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Veröffentlicht in:	Hepatology research 2001-06, Vol.20 (2), p.216-220
Hauptverfasser:	Takikawa, Hajime, Sano, Naoyo, Onishi, Toshiki, Ohashi, Masaki, Hasegawa, Yasumasa, Nishikawa, Kou
Format:	Artikel
Sprache:	eng
Schlagworte:	Biliary excretion Biological and medical sciences General pharmacology Hepatic zonation Liver injury Medical sciences Multidrug resistance protein 2 Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Temocapril
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