Behavioral effects of PCBs in mice

Behavioral effects of PCBs in mice

A single i.p. administration to mice of Fenclor 54 (PCB) resulted in various behavioral deficits. PCB significantly reduced locomotor activity and exploratory behavior at dosages of 150 and 300 mg/kg. Dose dependent increased latencies were also found at the same dosages in the “traction test” while...

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Veröffentlicht in:Behavioural pharmacology 1990, Vol.1 (6), p.505-510
Hauptverfasser: Fanini, D, Palumbo, G, Giorgi, R, Pantaleoni, G
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container_title Behavioural pharmacology
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creator Fanini, D
Palumbo, G
Giorgi, R
Pantaleoni, G
description A single i.p. administration to mice of Fenclor 54 (PCB) resulted in various behavioral deficits. PCB significantly reduced locomotor activity and exploratory behavior at dosages of 150 and 300 mg/kg. Dose dependent increased latencies were also found at the same dosages in the “traction test” while in the rota rod test the dosage of 300 mg/kg of PCB only caused a significant increase in mean number of falls off the rod. Furthermore daily dietary administration of PCB (1, 10, 100 ppm) to male mice during a 21-day isolation period was inversely proportional to the amount of aggressive behavior shown, and directly proportional to the amount of non-social behavior (“indifference”). This supports former findings reporting anti-androgenic like effects of PCBs.
doi_str_mv 10.1097/00008877-199000160-00004
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title Behavioral effects of PCBs in mice
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