A Kinetic Study on the Interaction between Tazobactam (A Penicillanic Acid Sulphone Derivative) and Active-Site Serine beta-Lactamases

A Kinetic Study on the Interaction between Tazobactam (A Penicillanic Acid Sulphone Derivative) and Active-Site Serine beta-Lactamases

The interaction between tazobactam and several chromosome- and plasmid-encoded (TEM, SHV, PSE types) class A and C beta-lactamases was studied by spectrophotometry. Tazobactam behaved as a competitive inhibitor or inactivator able to restore in several cases the efficiency of piperacillin as a partn...

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Veröffentlicht in:Journal of enzyme inhibition 1999-11, Vol.15 (1), p.1-10
Hauptverfasser: Perilli, M, Franceschini, N, Bonfiglio, G, Segatore, B, Stefani, S, Nicoletti, G, Tavio Perez Md, Bianchi, C, Zollo, A, Amicosante, G
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container_end_page 10
container_issue 1
container_start_page 1
container_title Journal of enzyme inhibition
container_volume 15
creator Perilli, M
Franceschini, N
Bonfiglio, G
Segatore, B
Stefani, S
Nicoletti, G
Tavio Perez Md
Bianchi, C
Zollo, A
Amicosante, G
description The interaction between tazobactam and several chromosome- and plasmid-encoded (TEM, SHV, PSE types) class A and C beta-lactamases was studied by spectrophotometry. Tazobactam behaved as a competitive inhibitor or inactivator able to restore in several cases the efficiency of piperacillin as a partner beta-lactam. A detailed kinetic analysis permitted measurement of the acylation efficiency for some cephalosporinases and broad-spectrum beta-lactamases; the presence of a turn-over of acyl-enzyme complex was also evaluated.
doi_str_mv 10.1080/14756369909030337
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title A Kinetic Study on the Interaction between Tazobactam (A Penicillanic Acid Sulphone Derivative) and Active-Site Serine beta-Lactamases
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