A Synthetic Hydroxy Acid That Shows Tubular-Shaped Structure in Solid-State and Ionophoric Activity in Phospholipid Bilayers

A Synthetic Hydroxy Acid That Shows Tubular-Shaped Structure in Solid-State and Ionophoric Activity in Phospholipid Bilayers

In this contribution, we describe the ability of compound (±)-1b and six molecules of water to form in solid-state hexameric aggregates, which self-assemble to give hollow tubular structures. Single-crystal X-ray analysis shows that these tubes are open-ended, with irregular shape and internal van d...

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Veröffentlicht in:Organic letters 2000-05, Vol.2 (9), p.1185-1188
Hauptverfasser: Pérez, Cirilo, Espínola, Carmen G, Foces-Foces, Concepción, Núñez-Coello, Pedro, Carrasco, Héctor, Martín, Julio D
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container_end_page 1188
container_issue 9
container_start_page 1185
container_title Organic letters
container_volume 2
creator Pérez, Cirilo
Espínola, Carmen G
Foces-Foces, Concepción
Núñez-Coello, Pedro
Carrasco, Héctor
Martín, Julio D
description In this contribution, we describe the ability of compound (±)-1b and six molecules of water to form in solid-state hexameric aggregates, which self-assemble to give hollow tubular structures. Single-crystal X-ray analysis shows that these tubes are open-ended, with irregular shape and internal van der Waals pore diameter between 6 and 9 Å. In addition, transmembrane sodium transport activity was also assessed for (±)-1b using dynamic Na+-NMR technique.
doi_str_mv 10.1021/ol005534j
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title A Synthetic Hydroxy Acid That Shows Tubular-Shaped Structure in Solid-State and Ionophoric Activity in Phospholipid Bilayers
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