The substantial impact of von Willebrand disease on menstruation
von Willebrand disease (vWd) is the most common of all congenital bleeding disorders with an estimated prevalence of 1–3% in the general population. However, the gynecological complications have not been thoroughly described. Objective: To compare the clinical and quality of life aspects of vWd in m...
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| Veröffentlicht in: | Primary care update for Ob/Gyns 1998-07, Vol.5 (4), p.153-154 |
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| container_title | Primary care update for Ob/Gyns |
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| creator | Kouides, P.A. Burkart, P. Phatak, P.D. Porter, J. Peacock, L. Braggins, C. Cox, C. Belling, L. Michalovic, D. Howard, F. |
| description | von Willebrand disease (vWd) is the most common of all congenital bleeding disorders with an estimated prevalence of 1–3% in the general population. However, the gynecological complications have not been thoroughly described.
Objective: To compare the clinical and quality of life aspects of vWd in menstruating women in relation to a cohort of menstruating women in the general population.
Methods: A patient questionnaire and provider survey of the medical and quality of life aspects of menstruation was administered to 81 menstruating vWd patients registered at four geographically linked Hemophilia Treatment Centers. The questionnaire was also administered to 150 menstruating women volunteers that comprised a control group used to determine normal coagulation levels in menstruating women. We assessed the impact on quality of life of menses in both of the cohorts by a Likert scale of 1–10 with 10 being “most significant impact” using 7 quality of life parameters with those comparisons by Wilcoxon rank sum test.
Results: 88% of the vWd patients (pts) had type I vWd, the remaining Type II or unknown. The mean age of the vWd patients was 31.6 ± 10.3; the mean age of the control group was 35.5 ± 7.6. The following comparisons were made using χ
2 and Wilcoxon rank sum test:
Controls
vWd pts
P value
# of tampons/pads used for a typical menstrual cycle (mean ± SD)
20.3 ± 9.1
26.5 ± 14.8
.002
% reporting that clothes are stained by menses
20.4%
69.1%
.001
Past or present history of anemia
1.3%
65.4%
.001
Impact of menses on general activity (mean score)
1.1 ± 1.8
4.2 ± 3.0 |
| doi_str_mv | 10.1016/S1068-607X(98)00039-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859322451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1068607X98000390</els_id><sourcerecordid>1859322451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2104-9c70e66bd5531c024a94a27c305bbc38beda7097466db31b87ca4ca6fd4cc8103</originalsourceid><addsrcrecordid>eNqFkEtLw0AQxxdRbH18BCXHeojOZjfJ5qRSfEHBgxW9LfuY4EoedTcp-O1NmwrePM0w_Gb-zI-QMwqXFGh29UIhE3EG-fusEBcAwIoY9siUilzEPBFsf-h_kQk5CuETgOaUi0MyoSCYSASfkpvlB0ah16FTTedUFbl6pUwXtWW0bpvozVUVaq8aG1kXUAWMhmmNTeh8rzrXNifkoFRVwNNdPSav93fL-WO8eH54mt8uYpNQ4HFhcsAs0zZNGTWQcFVwleSGQaq1YUKjVTkUOc8yqxnVIjeKG5WVlhsjKLBjMhvvrnz71WPoZO2CwapSDbZ9kFSkBUsSntIBTUfU-DYEj6VceVcr_y0pyI08uZUnN2ZkIeRWntxEnO8iel2j_bM12hqA6xHA4dG1Qy-DcdgYtM6j6aRt3T8RP7lwfsE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859322451</pqid></control><display><type>article</type><title>The substantial impact of von Willebrand disease on menstruation</title><source>Alma/SFX Local Collection</source><creator>Kouides, P.A. ; Burkart, P. ; Phatak, P.D. ; Porter, J. ; Peacock, L. ; Braggins, C. ; Cox, C. ; Belling, L. ; Michalovic, D. ; Howard, F.</creator><creatorcontrib>Kouides, P.A. ; Burkart, P. ; Phatak, P.D. ; Porter, J. ; Peacock, L. ; Braggins, C. ; Cox, C. ; Belling, L. ; Michalovic, D. ; Howard, F.</creatorcontrib><description><![CDATA[von Willebrand disease (vWd) is the most common of all congenital bleeding disorders with an estimated prevalence of 1–3% in the general population. However, the gynecological complications have not been thoroughly described.
Objective: To compare the clinical and quality of life aspects of vWd in menstruating women in relation to a cohort of menstruating women in the general population.
Methods: A patient questionnaire and provider survey of the medical and quality of life aspects of menstruation was administered to 81 menstruating vWd patients registered at four geographically linked Hemophilia Treatment Centers. The questionnaire was also administered to 150 menstruating women volunteers that comprised a control group used to determine normal coagulation levels in menstruating women. We assessed the impact on quality of life of menses in both of the cohorts by a Likert scale of 1–10 with 10 being “most significant impact” using 7 quality of life parameters with those comparisons by Wilcoxon rank sum test.
Results: 88% of the vWd patients (pts) had type I vWd, the remaining Type II or unknown. The mean age of the vWd patients was 31.6 ± 10.3; the mean age of the control group was 35.5 ± 7.6. The following comparisons were made using χ
2 and Wilcoxon rank sum test:
Controls
vWd pts
P value
# of tampons/pads used for a typical menstrual cycle (mean ± SD)
20.3 ± 9.1
26.5 ± 14.8
.002
% reporting that clothes are stained by menses
20.4%
69.1%
.001
Past or present history of anemia
1.3%
65.4%
.001
Impact of menses on general activity (mean score)
1.1 ± 1.8
4.2 ± 3.0
<.0001
Impact of menses on ability to work or go to school (mean score)
0.5 ± 1.4
3.2 ± 3.3
<.0001
Impact of menses on family activities (mean score)
0.6 ± 1.4
3.5 ± 2.9
<.0001
Impact of menses on ability to enjoy life (mean score)
0.9 ± 1.5
3.9 ± 3.3
<.0001
Impact of menses on sleep (mean score)
1.3 ± 2.3
3.6 ± 3.1
<.0001
Impact of menses on mood (mean score)
3.5 ± 2.8
5.6 ± 3.3
<.0001
Impact of menses on over-all quality of life (mean score)
1.7 ± 1.8
4.2 ± 3.1
<.0001
Conclusions: vWd markedly diminishes the quality of life during menses. This observation warrants efforts to reduce the attendant morbidities of vWd in menstruating women.]]></description><identifier>ISSN: 1068-607X</identifier><identifier>EISSN: 1878-4283</identifier><identifier>DOI: 10.1016/S1068-607X(98)00039-0</identifier><identifier>PMID: 10838284</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><ispartof>Primary care update for Ob/Gyns, 1998-07, Vol.5 (4), p.153-154</ispartof><rights>1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2104-9c70e66bd5531c024a94a27c305bbc38beda7097466db31b87ca4ca6fd4cc8103</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10838284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kouides, P.A.</creatorcontrib><creatorcontrib>Burkart, P.</creatorcontrib><creatorcontrib>Phatak, P.D.</creatorcontrib><creatorcontrib>Porter, J.</creatorcontrib><creatorcontrib>Peacock, L.</creatorcontrib><creatorcontrib>Braggins, C.</creatorcontrib><creatorcontrib>Cox, C.</creatorcontrib><creatorcontrib>Belling, L.</creatorcontrib><creatorcontrib>Michalovic, D.</creatorcontrib><creatorcontrib>Howard, F.</creatorcontrib><title>The substantial impact of von Willebrand disease on menstruation</title><title>Primary care update for Ob/Gyns</title><addtitle>Prim Care Update Ob Gyns</addtitle><description><![CDATA[von Willebrand disease (vWd) is the most common of all congenital bleeding disorders with an estimated prevalence of 1–3% in the general population. However, the gynecological complications have not been thoroughly described.
Objective: To compare the clinical and quality of life aspects of vWd in menstruating women in relation to a cohort of menstruating women in the general population.
Methods: A patient questionnaire and provider survey of the medical and quality of life aspects of menstruation was administered to 81 menstruating vWd patients registered at four geographically linked Hemophilia Treatment Centers. The questionnaire was also administered to 150 menstruating women volunteers that comprised a control group used to determine normal coagulation levels in menstruating women. We assessed the impact on quality of life of menses in both of the cohorts by a Likert scale of 1–10 with 10 being “most significant impact” using 7 quality of life parameters with those comparisons by Wilcoxon rank sum test.
Results: 88% of the vWd patients (pts) had type I vWd, the remaining Type II or unknown. The mean age of the vWd patients was 31.6 ± 10.3; the mean age of the control group was 35.5 ± 7.6. The following comparisons were made using χ
2 and Wilcoxon rank sum test:
Controls
vWd pts
P value
# of tampons/pads used for a typical menstrual cycle (mean ± SD)
20.3 ± 9.1
26.5 ± 14.8
.002
% reporting that clothes are stained by menses
20.4%
69.1%
.001
Past or present history of anemia
1.3%
65.4%
.001
Impact of menses on general activity (mean score)
1.1 ± 1.8
4.2 ± 3.0
<.0001
Impact of menses on ability to work or go to school (mean score)
0.5 ± 1.4
3.2 ± 3.3
<.0001
Impact of menses on family activities (mean score)
0.6 ± 1.4
3.5 ± 2.9
<.0001
Impact of menses on ability to enjoy life (mean score)
0.9 ± 1.5
3.9 ± 3.3
<.0001
Impact of menses on sleep (mean score)
1.3 ± 2.3
3.6 ± 3.1
<.0001
Impact of menses on mood (mean score)
3.5 ± 2.8
5.6 ± 3.3
<.0001
Impact of menses on over-all quality of life (mean score)
1.7 ± 1.8
4.2 ± 3.1
<.0001
Conclusions: vWd markedly diminishes the quality of life during menses. This observation warrants efforts to reduce the attendant morbidities of vWd in menstruating women.]]></description><issn>1068-607X</issn><issn>1878-4283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLw0AQxxdRbH18BCXHeojOZjfJ5qRSfEHBgxW9LfuY4EoedTcp-O1NmwrePM0w_Gb-zI-QMwqXFGh29UIhE3EG-fusEBcAwIoY9siUilzEPBFsf-h_kQk5CuETgOaUi0MyoSCYSASfkpvlB0ah16FTTedUFbl6pUwXtWW0bpvozVUVaq8aG1kXUAWMhmmNTeh8rzrXNifkoFRVwNNdPSav93fL-WO8eH54mt8uYpNQ4HFhcsAs0zZNGTWQcFVwleSGQaq1YUKjVTkUOc8yqxnVIjeKG5WVlhsjKLBjMhvvrnz71WPoZO2CwapSDbZ9kFSkBUsSntIBTUfU-DYEj6VceVcr_y0pyI08uZUnN2ZkIeRWntxEnO8iel2j_bM12hqA6xHA4dG1Qy-DcdgYtM6j6aRt3T8RP7lwfsE</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Kouides, P.A.</creator><creator>Burkart, P.</creator><creator>Phatak, P.D.</creator><creator>Porter, J.</creator><creator>Peacock, L.</creator><creator>Braggins, C.</creator><creator>Cox, C.</creator><creator>Belling, L.</creator><creator>Michalovic, D.</creator><creator>Howard, F.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>The substantial impact of von Willebrand disease on menstruation</title><author>Kouides, P.A. ; Burkart, P. ; Phatak, P.D. ; Porter, J. ; Peacock, L. ; Braggins, C. ; Cox, C. ; Belling, L. ; Michalovic, D. ; Howard, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2104-9c70e66bd5531c024a94a27c305bbc38beda7097466db31b87ca4ca6fd4cc8103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kouides, P.A.</creatorcontrib><creatorcontrib>Burkart, P.</creatorcontrib><creatorcontrib>Phatak, P.D.</creatorcontrib><creatorcontrib>Porter, J.</creatorcontrib><creatorcontrib>Peacock, L.</creatorcontrib><creatorcontrib>Braggins, C.</creatorcontrib><creatorcontrib>Cox, C.</creatorcontrib><creatorcontrib>Belling, L.</creatorcontrib><creatorcontrib>Michalovic, D.</creatorcontrib><creatorcontrib>Howard, F.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Primary care update for Ob/Gyns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kouides, P.A.</au><au>Burkart, P.</au><au>Phatak, P.D.</au><au>Porter, J.</au><au>Peacock, L.</au><au>Braggins, C.</au><au>Cox, C.</au><au>Belling, L.</au><au>Michalovic, D.</au><au>Howard, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The substantial impact of von Willebrand disease on menstruation</atitle><jtitle>Primary care update for Ob/Gyns</jtitle><addtitle>Prim Care Update Ob Gyns</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>5</volume><issue>4</issue><spage>153</spage><epage>154</epage><pages>153-154</pages><issn>1068-607X</issn><eissn>1878-4283</eissn><abstract><![CDATA[von Willebrand disease (vWd) is the most common of all congenital bleeding disorders with an estimated prevalence of 1–3% in the general population. However, the gynecological complications have not been thoroughly described.
Objective: To compare the clinical and quality of life aspects of vWd in menstruating women in relation to a cohort of menstruating women in the general population.
Methods: A patient questionnaire and provider survey of the medical and quality of life aspects of menstruation was administered to 81 menstruating vWd patients registered at four geographically linked Hemophilia Treatment Centers. The questionnaire was also administered to 150 menstruating women volunteers that comprised a control group used to determine normal coagulation levels in menstruating women. We assessed the impact on quality of life of menses in both of the cohorts by a Likert scale of 1–10 with 10 being “most significant impact” using 7 quality of life parameters with those comparisons by Wilcoxon rank sum test.
Results: 88% of the vWd patients (pts) had type I vWd, the remaining Type II or unknown. The mean age of the vWd patients was 31.6 ± 10.3; the mean age of the control group was 35.5 ± 7.6. The following comparisons were made using χ
2 and Wilcoxon rank sum test:
Controls
vWd pts
P value
# of tampons/pads used for a typical menstrual cycle (mean ± SD)
20.3 ± 9.1
26.5 ± 14.8
.002
% reporting that clothes are stained by menses
20.4%
69.1%
.001
Past or present history of anemia
1.3%
65.4%
.001
Impact of menses on general activity (mean score)
1.1 ± 1.8
4.2 ± 3.0
<.0001
Impact of menses on ability to work or go to school (mean score)
0.5 ± 1.4
3.2 ± 3.3
<.0001
Impact of menses on family activities (mean score)
0.6 ± 1.4
3.5 ± 2.9
<.0001
Impact of menses on ability to enjoy life (mean score)
0.9 ± 1.5
3.9 ± 3.3
<.0001
Impact of menses on sleep (mean score)
1.3 ± 2.3
3.6 ± 3.1
<.0001
Impact of menses on mood (mean score)
3.5 ± 2.8
5.6 ± 3.3
<.0001
Impact of menses on over-all quality of life (mean score)
1.7 ± 1.8
4.2 ± 3.1
<.0001
Conclusions: vWd markedly diminishes the quality of life during menses. This observation warrants efforts to reduce the attendant morbidities of vWd in menstruating women.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10838284</pmid><doi>10.1016/S1068-607X(98)00039-0</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-607X |
| ispartof | Primary care update for Ob/Gyns, 1998-07, Vol.5 (4), p.153-154 |
| issn | 1068-607X 1878-4283 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1859322451 |
| source | Alma/SFX Local Collection |
| title | The substantial impact of von Willebrand disease on menstruation |
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