Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers
Genetic variation of microsatellite loci is a widely used method for linkage analysis, individual identification or inter-population studies. Here we analyse a repeated DNA coding sequence and eleven new microsatellites identified within the Trypanosoma ( Trypanozoon) brucei genome. Ninety-seven iso...
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| Veröffentlicht in: | Molecular and biochemical parasitology 2000-02, Vol.105 (2), p.187-202 |
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| container_title | Molecular and biochemical parasitology |
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| creator | Biteau, N. Bringaud, F. Gibson, W. Truc, P. Baltz, T. |
| description | Genetic variation of microsatellite loci is a widely used method for linkage analysis, individual identification or inter-population studies. Here we analyse a repeated DNA coding sequence and eleven new microsatellites identified within the
Trypanosoma (
Trypanozoon)
brucei genome. Ninety-seven isolates belonging to the five species and subspecies
Trypanosoma evansi,
T. equiperdum,
T. brucei brucei,
T. b. rhodesiense and
T. b. gambiense were compared regarding the genetic patterns of these markers. The results reveal a great heterogeneity of the genotypes related to the repeated coding sequence and five microsatellites, some of which show a high degree of polymorphism. This allows us to define group-specific genotypes or alleles; in particular, we show that one specific pattern clearly segregates the human pathogen
T. b. gambiense group 1. |
| doi_str_mv | 10.1016/S0166-6851(99)00171-1 |
| format | Article |
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Trypanosoma (
Trypanozoon)
brucei genome. Ninety-seven isolates belonging to the five species and subspecies
Trypanosoma evansi,
T. equiperdum,
T. brucei brucei,
T. b. rhodesiense and
T. b. gambiense were compared regarding the genetic patterns of these markers. The results reveal a great heterogeneity of the genotypes related to the repeated coding sequence and five microsatellites, some of which show a high degree of polymorphism. This allows us to define group-specific genotypes or alleles; in particular, we show that one specific pattern clearly segregates the human pathogen
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Trypanosoma (
Trypanozoon)
brucei genome. Ninety-seven isolates belonging to the five species and subspecies
Trypanosoma evansi,
T. equiperdum,
T. brucei brucei,
T. b. rhodesiense and
T. b. gambiense were compared regarding the genetic patterns of these markers. The results reveal a great heterogeneity of the genotypes related to the repeated coding sequence and five microsatellites, some of which show a high degree of polymorphism. This allows us to define group-specific genotypes or alleles; in particular, we show that one specific pattern clearly segregates the human pathogen
T. b. gambiense group 1.</description><subject>Classification</subject><subject>Group specific markers</subject><subject>Human African trypanosomiasis</subject><subject>Microsatellite repeats</subject><subject>Polymorphism (Genetics)</subject><subject>Trypanosoma brucei</subject><issn>0166-6851</issn><issn>1872-9428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkE9PwyAYh4nRuDn9CBqOeqhCW1o4GbP4L1niwd0Jg7eKtqVCZ7J9eum6GG9eILw8L--PB6FzSq4pocXNa1yKpOCMXgpxRQgtaUIP0JTyMk1EnvJDNP1FJugkhA9CCCuL4hhNKClzRkk6RWb-rrzSPXi7Vb11LXYVXvpNp1q3dfFog6tVDwGvg23fsMIeOogFg7UzQyXA1xpaDVi1BjdWexfidV3bHnCj_Cf4cIqOKlUHONvvM7R8uF_On5LFy-Pz_G6R6LTkfZJVFReMFIUWimVsVaW6AMKMYJnOUyoMlFBlZqUyboQmnIFmJudppgCINtkMXY7Pdt7FTKGXjQ06RlEtuHWQlDORUZFzGlE2okPc4KGSnbcx7UZSIge_cudXDvKkEHLnVw59F_sR61UD5k_XKDQCtyMA8Z_fFrwM2g56jPWge2mc_WfED7-IjNY</recordid><startdate>20000205</startdate><enddate>20000205</enddate><creator>Biteau, N.</creator><creator>Bringaud, F.</creator><creator>Gibson, W.</creator><creator>Truc, P.</creator><creator>Baltz, T.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000205</creationdate><title>Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers</title><author>Biteau, N. ; Bringaud, F. ; Gibson, W. ; Truc, P. ; Baltz, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-3ff895066c9a535bf2c6e05d953c4219de7ef3dba38d9c085ec5d4823aee0cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Classification</topic><topic>Group specific markers</topic><topic>Human African trypanosomiasis</topic><topic>Microsatellite repeats</topic><topic>Polymorphism (Genetics)</topic><topic>Trypanosoma brucei</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biteau, N.</creatorcontrib><creatorcontrib>Bringaud, F.</creatorcontrib><creatorcontrib>Gibson, W.</creatorcontrib><creatorcontrib>Truc, P.</creatorcontrib><creatorcontrib>Baltz, T.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and biochemical parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biteau, N.</au><au>Bringaud, F.</au><au>Gibson, W.</au><au>Truc, P.</au><au>Baltz, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers</atitle><jtitle>Molecular and biochemical parasitology</jtitle><addtitle>Mol Biochem Parasitol</addtitle><date>2000-02-05</date><risdate>2000</risdate><volume>105</volume><issue>2</issue><spage>187</spage><epage>202</epage><pages>187-202</pages><issn>0166-6851</issn><eissn>1872-9428</eissn><abstract>Genetic variation of microsatellite loci is a widely used method for linkage analysis, individual identification or inter-population studies. Here we analyse a repeated DNA coding sequence and eleven new microsatellites identified within the
Trypanosoma (
Trypanozoon)
brucei genome. Ninety-seven isolates belonging to the five species and subspecies
Trypanosoma evansi,
T. equiperdum,
T. brucei brucei,
T. b. rhodesiense and
T. b. gambiense were compared regarding the genetic patterns of these markers. The results reveal a great heterogeneity of the genotypes related to the repeated coding sequence and five microsatellites, some of which show a high degree of polymorphism. This allows us to define group-specific genotypes or alleles; in particular, we show that one specific pattern clearly segregates the human pathogen
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| ispartof | Molecular and biochemical parasitology, 2000-02, Vol.105 (2), p.187-202 |
| issn | 0166-6851 1872-9428 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Classification Group specific markers Human African trypanosomiasis Microsatellite repeats Polymorphism (Genetics) Trypanosoma brucei |
| title | Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers |
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