Experimental study on liver regeneration after simultaneous partial hepatectomy and pancreatectomy
In this study, we performed hepatectomy and pancreatectomy to assess the physiological contribution of the pancreas, especially in terms of endocrine function to hepatic regeneration. Group 1 Wistar rats underwent 70% hepatectomy and group 2 rats underwent 70% hepatectomy plus 50% pancreatectomy. Th...
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Veröffentlicht in: | Hepatology research 2000-06, Vol.17 (3), p.223-236 |
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creator | Furuta, Kazunori Kakita, Akira Takahashi, Tsuyoshi Tomiya, Tomoaki Fujiwara, Kenji |
description | In this study, we performed hepatectomy and pancreatectomy to assess the physiological contribution of the pancreas, especially in terms of endocrine function to hepatic regeneration. Group 1 Wistar rats underwent 70% hepatectomy and group 2 rats underwent 70% hepatectomy plus 50% pancreatectomy. The time course assessment of liver regeneration rates obtained by Fishback’s formula demonstrated a difference in rates between the two groups as early as day 3 or day 7 after surgery. Since levels of both PCNA-positive cells and serum transforming growth factor-α (TGF-α) were significantly higher in the hepatectomy only group, we could prove the difference of liver regeneration between the two groups. We have concluded that pancreatectomy retards the liver regeneration initiation processes occurring from 24 h to 3 days after evisceration. Glucagon–insulin molar ratios most significantly differed between the two groups 3 days after evisceration in the present study. This result was due to increased glucagon level of group 2 at day 3 after evisceration. Our findings suggest that 50% partial pancreatectomy inhibits the rate of hepatic regeneration, thereby altering the supply of pancreatic hormones, especially glucagon. |
doi_str_mv | 10.1016/S1386-6346(99)00078-9 |
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Group 1 Wistar rats underwent 70% hepatectomy and group 2 rats underwent 70% hepatectomy plus 50% pancreatectomy. The time course assessment of liver regeneration rates obtained by Fishback’s formula demonstrated a difference in rates between the two groups as early as day 3 or day 7 after surgery. Since levels of both PCNA-positive cells and serum transforming growth factor-α (TGF-α) were significantly higher in the hepatectomy only group, we could prove the difference of liver regeneration between the two groups. We have concluded that pancreatectomy retards the liver regeneration initiation processes occurring from 24 h to 3 days after evisceration. Glucagon–insulin molar ratios most significantly differed between the two groups 3 days after evisceration in the present study. This result was due to increased glucagon level of group 2 at day 3 after evisceration. 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Our findings suggest that 50% partial pancreatectomy inhibits the rate of hepatic regeneration, thereby altering the supply of pancreatic hormones, especially glucagon.</description><subject>Hepatectomy</subject><subject>Liver regeneration</subject><subject>Pancreatectomy</subject><subject>TGF-α</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LBSEUhiWKvn9CMctaTOnoHXUVcekLghYVtJNz9dwy5it1ovvvs6agXSvl5Xk9x4eQA0ZPGGX16T3jqi5rLuojrY8ppVKVeo1sMyWrknLxtJ7vv8gW2YnxlVImaSU2yRajUgst622yuPgYMPgWuwRNEdPoVkXfFY1_x1AEfMYOAySfI1imHEXfjk2CDvsxFgOE5HPtBQdIaFPfrgroXM47G_A32iMbS2gi7v-cu-Tx8uJhfl3e3l3dzM9vS8t1lUoJSmuouAIl5AKY0iDV0gkNKJ1V1FYzrAS1YBfWckupchVV3IGSXEuBfJccTe8OoX8bMSbT-mixaaZtDVMzzZlSgmV0NqE29DEGXJohO4CwMoyaL73mW6_5cme0Nt96jc69w58R46JF96c1-czA2QRg_ui7x2Ci9dhZdD5kG8b1_p8Rn7wojN0</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Furuta, Kazunori</creator><creator>Kakita, Akira</creator><creator>Takahashi, Tsuyoshi</creator><creator>Tomiya, Tomoaki</creator><creator>Fujiwara, Kenji</creator><general>Elsevier Ireland Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>Experimental study on liver regeneration after simultaneous partial hepatectomy and pancreatectomy</title><author>Furuta, Kazunori ; Kakita, Akira ; Takahashi, Tsuyoshi ; Tomiya, Tomoaki ; Fujiwara, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-7a899a238a847ba189a78fd49ae7dc80c25e240cacbcc3c008d2083da873974e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Hepatectomy</topic><topic>Liver regeneration</topic><topic>Pancreatectomy</topic><topic>TGF-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furuta, Kazunori</creatorcontrib><creatorcontrib>Kakita, Akira</creatorcontrib><creatorcontrib>Takahashi, Tsuyoshi</creatorcontrib><creatorcontrib>Tomiya, Tomoaki</creatorcontrib><creatorcontrib>Fujiwara, Kenji</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furuta, Kazunori</au><au>Kakita, Akira</au><au>Takahashi, Tsuyoshi</au><au>Tomiya, Tomoaki</au><au>Fujiwara, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental study on liver regeneration after simultaneous partial hepatectomy and pancreatectomy</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>17</volume><issue>3</issue><spage>223</spage><epage>236</epage><pages>223-236</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>In this study, we performed hepatectomy and pancreatectomy to assess the physiological contribution of the pancreas, especially in terms of endocrine function to hepatic regeneration. Group 1 Wistar rats underwent 70% hepatectomy and group 2 rats underwent 70% hepatectomy plus 50% pancreatectomy. The time course assessment of liver regeneration rates obtained by Fishback’s formula demonstrated a difference in rates between the two groups as early as day 3 or day 7 after surgery. Since levels of both PCNA-positive cells and serum transforming growth factor-α (TGF-α) were significantly higher in the hepatectomy only group, we could prove the difference of liver regeneration between the two groups. We have concluded that pancreatectomy retards the liver regeneration initiation processes occurring from 24 h to 3 days after evisceration. Glucagon–insulin molar ratios most significantly differed between the two groups 3 days after evisceration in the present study. This result was due to increased glucagon level of group 2 at day 3 after evisceration. 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subjects | Hepatectomy Liver regeneration Pancreatectomy TGF-α |
title | Experimental study on liver regeneration after simultaneous partial hepatectomy and pancreatectomy |
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