Formation of Reactive Oxygen Species in Various Vascular Cells During Glyceryltrinitrate Metabolism

Background: Anti-ischemic therapy with organic nitrates as nitric oxide (NO) donors is complicated by the induction of tolerance. When nitrates are metabolized to release NO, there is a considerable coproduction of reactive oxygen species (superoxide radical and per oxynitrite) in vessels leading to...

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Veröffentlicht in:	Journal of cardiovascular pharmacology and therapeutics 1998, Vol.3 (1), p.51-61
Hauptverfasser:	Dikalov, S., Fink, B., Skatchkov, M., Sommer, O., Bassenge, E.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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