Advances in drug metabolism screening

Advances in drug metabolism screening

Developments in automation, analytical technologies and molecular biology are being exploited by drug metabolism scientists in order to provide enhanced in vitro systems for the study of the metabolic disposition of potential drug candidates. Routine investigation of factors such as metabolic stabil...

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Veröffentlicht in:Pharmaceutical science & technology today 1999-01, Vol.2 (1), p.13-19
Hauptverfasser: Eddershaw, PJ, Dickins, M
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container_title Pharmaceutical science & technology today
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creator Eddershaw, PJ
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description Developments in automation, analytical technologies and molecular biology are being exploited by drug metabolism scientists in order to provide enhanced in vitro systems for the study of the metabolic disposition of potential drug candidates. Routine investigation of factors such as metabolic stability and induction and inhibition of drug metabolizing enzymes is now preferred in the early stages of drug discovery. This, in turn, should provide a greater understanding of the underlying principles governing these processes and allow a greater role for drug metabolism in the design of new drug molecules.
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title Advances in drug metabolism screening
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