How antibiotics cause antibiotic resistance

How antibiotics cause antibiotic resistance

Antimicrobial agents are approaching the end of their effectiveness. The prevailing drug development strategy is based on a presumption that results in resistance: that disease can be cured by exploitation of the vulnerabilities in microbial reproduction. Although some did predict the evolution of r...

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Veröffentlicht in:Drug Discovery Today 1999-02, Vol.4 (2), p.72-79
1. Verfasser: Heinemann, Jack A.
Format: Artikel
Sprache:eng
Schlagworte:
Antibacterial agents
antibiotic resistance
antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
epigenetics
evolution
Horizontal gene transfer
Medical sciences
Pharmacology. Drug treatments
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creator Heinemann, Jack A.
description Antimicrobial agents are approaching the end of their effectiveness. The prevailing drug development strategy is based on a presumption that results in resistance: that disease can be cured by exploitation of the vulnerabilities in microbial reproduction. Although some did predict the evolution of resistance to such drugs, the mechanisms by which genes conferring resistance have spread was not predicted. The author argues that the mechanism of spread is a consequence of the chemotherapeutics themselves acting on the evolution of pathogens, and that for future drugs to remain effective they must avoid such effects.
doi_str_mv 10.1016/S1359-6446(98)01294-X
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source Elsevier ScienceDirect Journals
subjects Antibacterial agents
antibiotic resistance
antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
epigenetics
evolution
Horizontal gene transfer
Medical sciences
Pharmacology. Drug treatments
title How antibiotics cause antibiotic resistance
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