MYO18B, a Candidate Tumor Suppressor Gene at Chromosome 22q12.1, Deleted, Mutated, and Methylated in Human Lung Cancer

Loss of heterozygosity on chromosome 22q has been detected in approximately 60% of advanced nonsmall cell lung carcinoma (NSCLC) as well as small cell lung carcinoma (SCLC), suggesting the presence of a tumor suppressor gene on 22q that is involved in lung cancer progression. Here, we isolated a myo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-09, Vol.99 (19), p.12269-12274
Hauptverfasser:	Nishioka, Michiho, Kohno, Takashi, Tani, Masachika, Yanaihara, Nozomu, Tomizawa, Yoshio, Otsuka, Ayaka, Sasaki, Shigeru, Kobayashi, Keiko, Niki, Toshiro, Maeshima, Arafumi, Sekido, Yoshitaka, Minna, John D., Sone, Saburo, Yokota, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell Division - genetics Cell lines Chromosomes, Human, Pair 22 - genetics CpG Islands DNA Methylation DNA Mutational Analysis DNA, Complementary - genetics DNA, Neoplasm - genetics Epithelial cells Exons Gene Deletion Gene Expression Genes Genes, Tumor Suppressor Genetic mutation Genetics Humans Loss of Heterozygosity Lung cancer Lung neoplasms Lung Neoplasms - genetics Lung Neoplasms - pathology Lungs Methylation Molecular Sequence Data Mutation Myosin Heavy Chains - genetics Polymerase chain reaction Small cell lung carcinoma Tumor Cells, Cultured
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