Protein-mediated base flipping

Protein-mediated base flipping

Since the discovery that the DNA methyltransferase M. HhaI utilises a base flipping mechanism to expose its target cytosine during catalysis, this phenomenon has been observed in other nucleic acid modifying enzymes. The crystallographic analyses of such enzyme—DNA complexes have revealed the molecu...

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Veröffentlicht in:Current opinion in biotechnology 1998-08, Vol.9 (4), p.354-358
Hauptverfasser: Hornby, David P, Ford, Geoffrey C
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container_title Current opinion in biotechnology
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Ford, Geoffrey C
description Since the discovery that the DNA methyltransferase M. HhaI utilises a base flipping mechanism to expose its target cytosine during catalysis, this phenomenon has been observed in other nucleic acid modifying enzymes. The crystallographic analyses of such enzyme—DNA complexes have revealed the molecular features of extrahelical base stabilisation, but have been less informative about the flipping process itself.
doi_str_mv 10.1016/S0958-1669(98)80007-4
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