Developmental abnormalities in horseshoe crab embryos caused by exposure to heavy metals
We examined the effects of heavy metals on the development of horseshoe crabs using bioassays in which embryos at different stages were exposed either continuously or for 24 h. Abnormalities included segment-defective embryos, double embryos, embryos with abnormal eye areas, and no-posterior embryos...
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| Veröffentlicht in: | Archives of environmental contamination and toxicology 1998-07, Vol.35 (1), p.33-40 |
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| creator | ITOW, T LOVELAND, R. E BOTTON, M. L |
| description | We examined the effects of heavy metals on the development of horseshoe crabs using bioassays in which embryos at different stages were exposed either continuously or for 24 h. Abnormalities included segment-defective embryos, double embryos, embryos with abnormal eye areas, and no-posterior embryos. In terms of their ability to affect normal development, the pollutants are ranked as follows: Hg >== organotin > Cr falling dots Cd > Cu > Pb > Zn. Organotin treatment was associated with a high frequency of abnormal eye embryos and Hg with segment-defective embryos. The specific cause of segment-defective malformations by Hg was investigated by using SH inhibitors and cytochalasin B, an inhibitor of microfilaments. These inhibitors induced Hg-type segment-defective embryos; thus, Hg may also act by inhibiting SH-SS exchange and blocking morphogenetic movements. Horseshoe crab embryos from Delaware Bay and Sandy Hook Bay, New Jersey, were examined for developmental abnormalities. Malformed embryos were extremely rare ( |
| doi_str_mv | 10.1007/s002449900345 |
| format | Article |
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E ; BOTTON, M. L</creator><creatorcontrib>ITOW, T ; LOVELAND, R. E ; BOTTON, M. L</creatorcontrib><description>We examined the effects of heavy metals on the development of horseshoe crabs using bioassays in which embryos at different stages were exposed either continuously or for 24 h. Abnormalities included segment-defective embryos, double embryos, embryos with abnormal eye areas, and no-posterior embryos. In terms of their ability to affect normal development, the pollutants are ranked as follows: Hg >== organotin > Cr falling dots Cd > Cu > Pb > Zn. Organotin treatment was associated with a high frequency of abnormal eye embryos and Hg with segment-defective embryos. The specific cause of segment-defective malformations by Hg was investigated by using SH inhibitors and cytochalasin B, an inhibitor of microfilaments. These inhibitors induced Hg-type segment-defective embryos; thus, Hg may also act by inhibiting SH-SS exchange and blocking morphogenetic movements. Horseshoe crab embryos from Delaware Bay and Sandy Hook Bay, New Jersey, were examined for developmental abnormalities. Malformed embryos were extremely rare (<0.6%) at five beaches along Delaware Bay as well as Sandy Hook Bay, suggesting that these horseshoe crab spawning areas are relatively unpolluted by heavy metals.</description><identifier>ISSN: 0090-4341</identifier><identifier>EISSN: 1432-0703</identifier><identifier>DOI: 10.1007/s002449900345</identifier><identifier>PMID: 9601916</identifier><identifier>CODEN: AECTCV</identifier><language>eng</language><publisher>Heidelberg: Springer-Verlag</publisher><subject>Animal, plant and microbial ecology ; Applied ecology ; Bioassays ; Biological and medical sciences ; Crustaceans ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on protozoa and invertebrates ; Embryos ; Fundamental and applied biological sciences. 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E</creatorcontrib><creatorcontrib>BOTTON, M. L</creatorcontrib><title>Developmental abnormalities in horseshoe crab embryos caused by exposure to heavy metals</title><title>Archives of environmental contamination and toxicology</title><addtitle>Arch Environ Contam Toxicol</addtitle><description>We examined the effects of heavy metals on the development of horseshoe crabs using bioassays in which embryos at different stages were exposed either continuously or for 24 h. Abnormalities included segment-defective embryos, double embryos, embryos with abnormal eye areas, and no-posterior embryos. In terms of their ability to affect normal development, the pollutants are ranked as follows: Hg >== organotin > Cr falling dots Cd > Cu > Pb > Zn. Organotin treatment was associated with a high frequency of abnormal eye embryos and Hg with segment-defective embryos. The specific cause of segment-defective malformations by Hg was investigated by using SH inhibitors and cytochalasin B, an inhibitor of microfilaments. These inhibitors induced Hg-type segment-defective embryos; thus, Hg may also act by inhibiting SH-SS exchange and blocking morphogenetic movements. Horseshoe crab embryos from Delaware Bay and Sandy Hook Bay, New Jersey, were examined for developmental abnormalities. 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E</au><au>BOTTON, M. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental abnormalities in horseshoe crab embryos caused by exposure to heavy metals</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><addtitle>Arch Environ Contam Toxicol</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>35</volume><issue>1</issue><spage>33</spage><epage>40</epage><pages>33-40</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><coden>AECTCV</coden><abstract>We examined the effects of heavy metals on the development of horseshoe crabs using bioassays in which embryos at different stages were exposed either continuously or for 24 h. Abnormalities included segment-defective embryos, double embryos, embryos with abnormal eye areas, and no-posterior embryos. In terms of their ability to affect normal development, the pollutants are ranked as follows: Hg >== organotin > Cr falling dots Cd > Cu > Pb > Zn. Organotin treatment was associated with a high frequency of abnormal eye embryos and Hg with segment-defective embryos. The specific cause of segment-defective malformations by Hg was investigated by using SH inhibitors and cytochalasin B, an inhibitor of microfilaments. These inhibitors induced Hg-type segment-defective embryos; thus, Hg may also act by inhibiting SH-SS exchange and blocking morphogenetic movements. Horseshoe crab embryos from Delaware Bay and Sandy Hook Bay, New Jersey, were examined for developmental abnormalities. Malformed embryos were extremely rare (<0.6%) at five beaches along Delaware Bay as well as Sandy Hook Bay, suggesting that these horseshoe crab spawning areas are relatively unpolluted by heavy metals.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>9601916</pmid><doi>10.1007/s002449900345</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0090-4341 |
| ispartof | Archives of environmental contamination and toxicology, 1998-07, Vol.35 (1), p.33-40 |
| issn | 0090-4341 1432-0703 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Animal, plant and microbial ecology Applied ecology Bioassays Biological and medical sciences Crustaceans Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on protozoa and invertebrates Embryos Fundamental and applied biological sciences. Psychology Heavy metals Limulus polyphemus Mercury Metals Spawning |
| title | Developmental abnormalities in horseshoe crab embryos caused by exposure to heavy metals |
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