Isotope-Filtered Affinity NMR

A double-editing pulse sequence has been developed that allows the direct observation of protein binding ligand(s) from a mixture of compounds. This technique should aid the discovery of lead pharmaceutical compounds. The proton NMR signals from protein and the nonbinding ligands are simultaneously...

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Bibliographische Detailangaben

Veröffentlicht in:	Journal of magnetic resonance (1997) 1998-04, Vol.131 (2), p.336-338
Hauptverfasser:	Gonnella, Nina, Lin, Mengfen, Shapiro, Michael J., Wareing, James R., Zhang, Xiaolu
Format:	Artikel
Sprache:	eng
Schlagworte:	13C isotope editing affinity NMR Diffusion NMR protein binding pulse sequence
Online-Zugang:	Volltext
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