Efficacy of the non-peptide CGRP receptor antagonist BIBN4096BS in blocking CGRP-induced dilations in human and bovine cerebral arteries: potential implications in acute migraine treatment

Calcitonin gene-related peptide (CGRP) is a potent vasodilator in brain vessels and it has been implicated in the pathogenesis of migraine headache. Blocking post-junctional CGRP receptors, mediators of trigeminal-induced vasodilation, has been suggested as a potential antimigraine strategy. In this...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuropharmacology 2002-03, Vol.42 (4), p.568-576
Hauptverfasser:	Moreno, M.J, Abounader, R, Hébert, E, Doods, H, Hamel, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals BIBN4096BS Biological and medical sciences Calcitonin Gene-Related Peptide - analogs & derivatives Calcitonin Gene-Related Peptide - antagonists & inhibitors Calcitonin Gene-Related Peptide - pharmacology Calcitonin Gene-Related Peptide Receptor Antagonists Cardiovascular system Cattle Cerebral Arteries - drug effects Cerebral Arteries - physiology CGRP receptor antagonist CGRP-mediated dilation Dose-Response Relationship, Drug Female Headache Humans Male Medical sciences Migraine Migraine Disorders - drug therapy Migraine Disorders - physiopathology Pharmacology. Drug treatments Piperazines - pharmacology Piperazines - therapeutic use Quinazolines - pharmacology Quinazolines - therapeutic use Receptors, Calcitonin Gene-Related Peptide - physiology Trigeminovascular system Vasodilation - drug effects Vasodilation - physiology Vasodilator agents. Cerebral vasodilators α-CGRP 8–37
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!