Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region

We performed a screen for drugs that specifically interact with the 5' untranslated region of the mRNA coding for the Alzheimer's Amyloid Precursor Protein (APP). Using a transfection based assay, in which APP 5'UTR sequences drive the translation of a downstream luciferase reporter g...

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Veröffentlicht in:	Journal of molecular neuroscience 2002-08, Vol.19 (1-2), p.77-82
Hauptverfasser:	Rogers, Jack T, Randall, Jeffrey D, Eder, Paul S, Huang, Xudong, Bush, Ashley I, Tanzi, Rudolph E, Venti, Amanda, Payton, Sandra M, Giordano, Tony, Nagano, Seiichi, Cahill, Catherine M, Moir, Robert, Lahiri, Debomoy K, Greig, Nigel, Sarang, Satinder Singh, Gullans, Steven R
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - drug effects Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Protein Precursor - drug effects Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Drug Approval FDA approval Genes Humans Luciferases - genetics Pharmaceutical Preparations Protein Biosynthesis RNA, Messenger - drug effects Transfection Tumor Cells, Cultured United States
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