Interference of lead with the calcium release activated calcium flux of osteoblast-like cells

Lead (Pb(2+)) tends to accumulate in bone from where it is released during bone resorption, thus leading to high local concentrations of Pb(2+) with the risk of cellular toxicity. We investigated the interference of Pb(2+) with the calcium release activated calcium influx (CRAC) of osteoblast-like (...

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Veröffentlicht in:	Calcified tissue international 1999-12, Vol.65 (6), p.479-485
Hauptverfasser:	Wiemann, M, Schirrmacher, K, Büsselberg, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Calcimycin - pharmacology Calcium - metabolism Calcium Channels - drug effects Cells, Cultured Chelating Agents - pharmacology Ethylenediamines - pharmacology Fura-2 - metabolism Lead - pharmacology Osteoblasts - drug effects Osteoblasts - metabolism Rats Thapsigargin - pharmacology
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