Reduced mortality by meeting guideline criteria before using recombinant activated factor VII in severe trauma patients with massive bleeding

Management of trauma patients with severe bleeding has led to criteria before considering use of recombinant activated factor VII (rFVIIa), including haemoglobin >8 g dl−1, serum fibrinogen ≥1.0 g l−1, platelets >50,000 × 109l−1, arterial pH ≥ 7.20, and body temperature ≥34 °C. We hypothesized...

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